Tryptin Plus (12.5mg+5mg) Tablet

✔️ Uses of Tryptin Plus

• Treatment of Depression

✔️ Composition of Tryptin Plus

Amitriptyline Hydrochloride + Chlordiazepoxide

✔️ How does Tryptin Plus work?

Tryptin Plus combines two active ingredients: Amitriptyline and Chlordiazepoxide. Amitriptyline, a tricyclic antidepressant, increases the levels of neurotransmitters in the brain that help regulate mood and treat depression. Chlordiazepoxide is a benzodiazepine that enhances the action of GABA, a neurotransmitter that suppresses abnormal and excessive nerve activity in the brain.

✔️ Side Effects of Tryptin Plus

Side Effects
Common side effects: Some symptoms, such as anorexia, fatigue, weakness, restlessness, and lethargy, are often associated with the depressive state and may also occur during treatment.

Adverse reactions: The most frequently reported adverse effects include drowsiness, dry mouth, constipation, blurred vision, dizziness, and bloating. Less common side effects may include vivid dreams, impotence, tremors, confusion, and nasal congestion.

Overdose Effects
Overdose of this medication can be fatal. Critical symptoms of Amitriptyline overdose include heart rhythm disturbances, severe low blood pressure, convulsions, and central nervous system (CNS) depression, including coma. Symptoms of Chlordiazepoxide overdose include drowsiness, confusion, coma, and diminished reflexes.

Withdrawal symptoms similar to those experienced with barbiturates and alcohol (e.g., convulsions, tremors, abdominal and muscle cramps, vomiting, and sweating) have been reported following the abrupt discontinuation of Chlordiazepoxide. Milder withdrawal symptoms (e.g., dysphoria and insomnia) have been reported after discontinuing benzodiazepines taken for several months. Symptoms such as nausea, headache, and malaise have also been reported with abrupt discontinuation of Amitriptyline.

✔️ Quick Suggestions:

• Tryptin Plus is prescribed for the treatment of depression.
• It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
• Do not stop taking Tryptin Plus unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
• Inform your doctor if you are taking any other antidepressants.
• Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
• Avoid alcohol while taking Tryptin Plus
• If you have diabetes, you will be asked to monitor your blood glucose level regularly as Tryptin Plus may affect the levels of sugar in your blood.

✔️ Indication of Tryptin Plus

Tryptin Plus is used to treat anxiety like unexpected extreme fear and tension due to stress. It is recommended to start with a small dosage and increase gradually. Do not stop taking this medicine as it may cause withdrawal symptoms like seizures, aggressive behavior, and blurred vision.

✔️ Pharmacology

This combination contains Amitriptyline, a tricyclic antidepressant, and Chlordiazepoxide, an anxiolytic. Amitriptyline works by inhibiting the reuptake of norepinephrine and serotonin in the brain, contributing to its antidepressant effects. Chlordiazepoxide enhances GABA-mediated chloride influx through GABA receptor channels, leading to membrane hyperpolarization and producing sedative and anxiolytic effects.

✔️ Dosage & Administration of Tryptin Plus

The optimal dosage varies depending on symptom severity and individual response. Once a satisfactory response is achieved, the dosage should be reduced to the minimum necessary to maintain remission. A larger portion of the daily dose may be taken at bedtime, and in some cases, a single bedtime dose may suffice. Typically, a starting dose of 3 or 4 tablets per day, divided into smaller doses, is recommended, or as directed by a physician.

• Pediatric use: Safety and efficacy have not been established in children. The potential risks must be weighed against the clinical need before prescribing this medication to children or adolescents.
• Geriatric use: In elderly or debilitated patients, the dosage should be limited to the smallest effective amount to avoid ataxia, over-sedation, confusion, or anticholinergic effects.

Take the medicine only as advised by a registered physician.

✔️ Interaction

Due to the Amitriptyline component, this medication may interfere with the antihypertensive effects of guanethidine or similar drugs.

✔️ Contraindications

It is contraindicated in patients who are hypersensitive to either benzodiazepines or tricyclic antidepressants. It should not be taken with monoamine oxidase inhibitors (MAOIs).

✔️ Pregnancy & Lactation

The safety of this medication during pregnancy and breastfeeding has not been established.

✔️ Precautions & Warnings

This medication should be used with caution in patients with a history of seizures. Close monitoring is required for hyperthyroid patients or those taking thyroid medication. Standard precautions should be taken when treating patients with renal or hepatic impairment. All pediatric patients taking antidepressants should be closely monitored for signs of worsening symptoms, suicidal thoughts, or unusual behavior changes.

✔️ Storage Conditions:

Store in a cool, dry place, protected from light. Keep all medicines out of reach of children.