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Loperamide, which is a member of the class of medications known as antidiarrheals, is present in Imotil 2mg. It is used to treat acute bouts of diarrhea related to irritable bowel syndrome (a collection of symptoms that affects the digestive system such as stomach cramps, gas, bloating, and diarrhea) in adults and children over the age of 12. (in adults aged 18 years and over).
Imotil 2 may cause excessive drowsiness with alcohol.
Imotil 2 may be unsafe to use during pregnancy. Although there are limited studies on humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Please consult your doctor.
Imotil 2 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Imotil 2 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Imotil 2 is safe to use in patients with kidney disease. No dose adjustment of Imotil 2 is recommended. However, inform your doctor if you have any underlying kidney disease.
Imotil 2 should be used with caution in patients with liver disease. A dose adjustment of Imotil 2 may be needed. Please consult your doctor.
Take Imotil 2 in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Imotil 2 may be taken with or without food, but it is better to take it at a fixed time.
Imotil 2 is an anti-diarrhoeal medication. It works by slowing down the contraction of the intestines thereby decreasing the speed at which the contents pass through it. This allows more time for the reabsorption of fluids and nutrients, making the stools more solid and less frequent.
Imotil is a very effective anti-diarrhea medication. Imotil is used to relieve the symptoms of diarrhea that start suddenly and lasts for a few days. Imotil is also used to treat long-term diarrhea associated with other diseases.
Imotil interacts with the cholinergic and noncholinergic neural systems that generate the peristaltic reflex to suppress the peristaltic activity of the longitudinal and circular smooth muscle of the colon. Loperamide inhibits propulsive peristalsis and lengthens intestinal transit time by binding to the opiate receptor in the gut wall.
Acute Diarrhea-
Chronic DiarrhoeaInitial Initial Dose:
Loperamide is a capsule that is taken orally.
After administration, absorption is greater than 65% at a moderate rate, with peak serum levels of 2-3 gm/liter occurring about 4 hours later.
The remaining 35% is excreted in the feces unchanged. Loperamide is extensively metabolized in the gut wall and the liver during its first-pass metabolism.
Because of its high affinity for the gut wall and systemic metabolism, loperamide does not act centrally.
This is why Imotil only reaches systemic circulation in trace amounts.
Imotil is eliminated in urine at 0.63-1.4% as an unchanged drug, in bile at 58%, and in feces at 15-23%.
Drug interactions might alter how your drugs function or raise the possibility of major negative side effects. All probable medication interactions are not included in this text. Keep a list of everything you use, including herbal items, prescriptions, and over-the-counter medications, and provide it to your doctor and pharmacist. Without your doctor's consent, never start, stop, or change the dosage of any medications.
Some products that may interact with this drug include pramlintide, recent/current antibiotic use, drugs that can cause constipation (including anticholinergics such as belladonna/scopolamine, antispasmodics such as glycopyrrolate/oxybutynin, potent opioid pain medicines such as morphine, certain antihistamines such as diphenhydramine, tricyclic antidepressants such as amitriptyline), cholestyramine, ritonavir, saquinavir.
If someone has overdosed and has serious symptoms such as passing out, immediately should go to the hospital
The safety of the use of Loperamide during pregnancy has not been established, although studies in animals did not demonstrate any teratogenic effects. Therefore, it should not be administered to patients during pregnancy. Although the fraction of loperamide secreted in human milk is very low, caution is advised if it is to be administered to nursing mothers.
It should be used with caution in patients with defective hepatic function as this might result in a relative overdose. Symptoms of overdose includes increased heart rate, irregular heartbeat, muscle stiffness, uncoordinated movements, drowsiness, difficulty urinating or weak breathing.
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