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Tegretol CR 200mg Tablet 10pcs
Tegretol CR is indicated for:
- Partial and secondary generalized tonic-clonic seizures
- Primary generalized tonic-clonic seizures
- Trigeminal neuralgia
- Prophylaxis of bipolar disorder
Use as directed by a registered physician.
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✅ Description:
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✔️ Uses:
Epilepsy, Schizophrenia, Bipolar disorder, Trigeminal neuralgia
✔️ Dosage & Administration
Epilepsy
Adults & Children ≥12 years:
- Initial dose: 200 mg twice daily (tablets/controlled release) or 1 tsp four times daily (suspension).
- Increment: Increase by up to 200 mg/day weekly until optimal response.
- Maintenance dose: Typically 800–1200 mg daily (max: 1600 mg in rare cases).
Children 6–12 years:
- Initial dose: 100 mg twice daily (tablets/controlled release) or ½ tsp four times daily (suspension).
- Increment: Increase by up to 100 mg/day weekly.
- Maintenance dose: Typically 400–800 mg daily (max: 1000 mg).
Children <6 years:
- Initial dose: 10–20 mg/kg/day in divided doses (2–4 times daily).
- Increment: Weekly increments until the optimal response.
- Maintenance dose: Usually below 35 mg/kg/day.
Combination therapy: When combined with other anticonvulsants, Carbamazepine should be introduced gradually.
Trigeminal Neuralgia
- Initial dose: 100 mg twice daily (tablets/controlled release) or ½ tsp four times daily (suspension).
- Increment: Increase by 100 mg every 12 hours as needed (max: 1200 mg/day).
- Maintenance dose: 400–800 mg/day (minimum effective dose).
Regular attempts (every 3 months) should be made to reduce the dose to the minimum effective level.
✔️ Side Effects
- Dizziness, drowsiness, nausea, vomiting, dry mouth, abdominal pain, anorexia.
- Ataxia, leucopenia, bradycardia, hypotension, proteinuria.
- Skin reactions (erythematous rash, peeling).
- Hematological issues (e.g., aplastic anemia).
- Cardiovascular problems (e.g., heart failure).
✔️ Drug Interactions
- Oral Contraceptives: May reduce effectiveness, leading to breakthrough bleeding.
- With Other Drugs:
- Hepatic enzyme inducers (e.g., phenytoin) may increase Carbamazepine metabolism, requiring a higher dose.
- May interact with tricyclic antidepressants or MAOIs if taken within the past 14 days.
✔️ Tegretol CR is contraindicated in:
- Hypersensitivity to Carbamazepine or related drugs.
- Heart block (atrioventricular block).
- Bone marrow depression.
- Hereditary porphyrias.
- Recent use of MAOIs (within 14 days).
✔️ Pregnancy & Lactation
- Pregnancy: Category D (potential risk to the fetus). Use only if benefits outweigh risks.
- Lactation: Carbamazepine and its metabolites are excreted in breast milk. Consider discontinuing the drug or breastfeeding.
✔️ Precautions & Warnings
- May cause drowsiness/dizziness; avoid driving or operating machinery.
- Skin reactions: Seek medical advice if rash, itching, or skin peeling occurs.
- Liver problems: Monitor for symptoms like jaundice, dark urine, nausea, or abdominal pain.
- May reduce the effectiveness of hormonal contraceptives; alternative methods are recommended.
- Do not stop medication suddenly; withdrawal should be supervised by a physician.
✔️ Caution is advised in:
- Elderly patients.
- Mixed seizures (including absence seizures).
- History of liver, kidney, or heart disease.
- Glaucoma or increased intraocular pressure.
✔️ Storage Conditions
- Store below 30°C.
- Protect from light and moisture.
- Keep out of the reach of children.
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
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