Griseofulvin is used to treat-
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Griseofulvin 500mg Tablet contains Griseofulvin, which falls under the category of anti-fungal drugs. It is prescribed for the treatment of fungal infections affecting the skin, scalp, hair, groin, feet, or nails, especially when topical treatments are either ineffective or unsuitable.
Fungal infections, also known as mycoses, are conditions where fungi invade and infect tissues, causing various symptoms and discomfort. Some fungal infections can be contagious, spreading from one person to another. Here are a few common fungal infections:
These fungal infections can be treated with antifungal medications, either topically or orally, depending on the severity and location of the infection. It's essential to maintain good hygiene and avoid sharing personal items like towels and shoes to prevent the spread of these infections. If you suspect you have a fungal infection, it's advisable to consult a healthcare professional for proper diagnosis and treatment.
Avoid consumption of alcohol while taking Griseofulvin 500mg Tablet as it may make alcohol affect you more (nausea, vomiting, blush, irregular heartbeat, chest pain, or abdominal pain).
Do not take Griseofulvin 500mg Tablet if you are pregnant or think you might be pregnant. Consult your doctor immediately if you are taking Griseofulvin 500mg Tablet and you get pregnant.
Griseofulvin 500mg Tablet is not recommended for use in breastfeeding. Consult your doctor before taking it.
Do not drive or operate any machines after taking Griseofulvin 500mg Tablet as it may cause drowsiness, dizziness, confusion, and lack of coordination.
Take Griseofulvin 500mg Tablet with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Griseofulvin 500mg Tablet is not recommended in patients with severe liver disease. It should be used with caution if you have liver disease. Consult your doctor before taking it.
Griseofulvin 500mg Tablet inhibits the growth of fungi by binding to a part of the fungus causing the infection in the body. This stops the fungus from multiplying. It also prevents fungus from spreading to new cells. These actions cause the fungal infection to shed completely.
Griseofulvin is primarily used to treat the following conditions:
Griseofulvin works by preventing the growth of fungi responsible for ringworm infections affecting the hair, skin, and nails. These fungi include various species such as Trichophyton rubrum, Trichophyton tonsurans, and Microsporum canis. It is essential to identify the specific fungus causing the infection before starting treatment, and griseofulvin is not necessary for minor infections treatable with topical antifungal medications.
Griseofulvin is a fungistatic drug, and while its exact mechanism of action is not fully understood, it is believed to inhibit fungal cell division and the synthesis of nuclear acids. It also interferes with the function of cellular microtubules, specifically alpha and beta tubulin. Griseofulvin attaches to human keratin cells and then binds to fungal microtubules at the site of infection, disrupting the fungal cell division process.
Accurate diagnosis of the infecting fungus is crucial. Diagnosis can be made through microscopic examination of infected tissue in a potassium hydroxide solution or by culturing the fungus on an appropriate medium. Medication should be continued until the infection is completely eradicated, as confirmed by clinical or laboratory assessments. Treatment durations vary depending on the type of infection.
For adults, a daily dose of 500 mg is usually effective for tinea corporis, tinea cruris, and tinea capitis. In more challenging cases like tinea pedis and tinea unguium, a daily dose of 1.0 gm is recommended. Children should receive approximately 5 mg per pound of body weight per day, with specific dosages based on weight.
It's important to take griseofulvin with food, preferably immediately after meals.
Patients taking warfarin-type anticoagulants may require adjustments to their anticoagulant doses during and after griseofulvin therapy. Concurrent use of barbiturates can reduce the effectiveness of griseofulvin and may necessitate higher dosages.
Griseofulvin is not recommended for individuals with porphyria, hepatic failure, or a history of hypersensitivity to the drug. Pregnant women should not be prescribed griseofulvin, as it has been associated with instances of conjoined twins when used during the first trimester of pregnancy.
Griseofulvin is classified as Pregnancy Type C, indicating that either animal studies have shown adverse effects on the fetus, or there are no controlled studies in women. It should only be administered during pregnancy if the potential benefits outweigh the potential risks to the fetus.
Patients on long-term griseofulvin treatment should undergo regular monitoring of organ system functions, including renal, hepatic, and hemopoietic functions. While there is a potential risk of cross-sensitivity with penicillin due to griseofulvin's origins, known penicillin-sensitive individuals have been successfully treated. Due to the occasional association of photosensitivity reactions with griseofulvin, patients should be advised to avoid prolonged exposure to direct sunlight, whether natural or artificial and lupus erythematosus may worsen if a photosensitivity reaction occurs.
Griseofulvin should be stored at temperatures between 15 and 30 degrees Celsius.
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