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Indications
Pharmacology
The difluorinated derivative of cinnarizine is flunarizine. It is a calcium channel antagonist that is selective. Calcium transmembrane inflow is reduced by decreasing excessive calcium transmembrane influx. Flunarizine inhibits calcium excess in cells. It has no effect on normal calcium homeostasis in cells. Flunarizine also has some antihistaminic and sedative properties. It binds to plasma protein with a 99 percent affinity.
Dosage & Administration
Interaction
Galactorrhoea has been recorded in a small number of women taking oral contraceptives during the first two months of therapy with Flunarizine. Carbamazepine and phenytoin, both hepatic enzyme inducers, may interact with flunarizine by increasing its metabolism. As a result, an increase in flunarizine dose may be necessary.
Contraindications
Flunarizine hypersensitivity. Flunarizine is not recommended for those who have had a depressive episode in the past, or who have signs of Parkinson's disease or other extrapyramidal diseases.
Side Effect
Drowsiness and/or fatigue, as well as weight gain and/or increased appetite, may occur. The following adverse experiences have been reported during chronic treatment with Flunarizine: depression, of which female patients with a history of depressive illness may be particularly at risk; extrapyramidal symptoms (such as bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor), of which elderly patients seem particularly at risk. Infrequently reported adverse reactions are: heartburn; nausea; gastralgia; insomnia; anxiety; galactorrhoea; dry mouth; muscle aches; skin rash.
Pregnancy & Lactation
There is no evidence of safety during pregnancy or lactation.
Precautions & Warnings
Flunarizine may cause sleepiness, which is exacerbated if alcohol or other central nervous system depressants are used at the same time. Patients should be warned about driving or undertaking other potentially dangerous occupations when a loss of mental awareness might result in an accident. Flunarizine isn't recommended for stopping a migraine. The possibility of an attack is consequently no cause to raise Flunarizine dosage. This therapy may cause extrapyramidal and depressive symptoms, as well as disclose Parkinsonism, particularly in individuals who are susceptible to it, such as the elderly. In such individuals, flunarizine should be administered with care.
Storage Conditions
Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.
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