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Oteseconazole belongs to the azole class of antifungals and targets CYP51, an enzyme crucial for building fungal cell membranes. Blocking this enzyme disrupts fungal growth and survival by accumulating harmful sterol byproducts. Its unique tetrazole structure also makes it less likely to interfere with human enzymes, offering improved safety.
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✅ Description:
Otes is prescribed to help prevent recurrent vulvovaginal candidiasis (RVVC) in adult females who are not able to conceive and have a history of frequent fungal infections. It can be used alone or alongside fluconazole, depending on the treatment plan. The medication works by inhibiting the growth and reproduction of yeast or fungal organisms.
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✔️ Side Effects
- Nausea
- Headache
- Hot flushes
- Painful or burning urination
- Heavy or prolonged vaginal bleeding
- Menstrual changes
✔️ Dosage & Administration:
Take exactly as prescribed. Swallow the capsule whole—do not chew, crush, or open it. Always take with food.
Option 1: Oteseconazole Alone
Day 1: 600 mg (single dose)
Day 2: 450 mg (single dose)
Day 14 onwards: 150 mg once weekly for 11 weeks (Weeks 2–12)
Option 2: With Fluconazole
Days 1, 4, 7: Fluconazole 150 mg daily
Days 14–20: Oteseconazole 150 mg daily
From Day 28 onwards: Oteseconazole 150 mg once weekly for 11 weeks (Weeks 4–14)
✔️ Tell your doctor about all other medicines you use. The following may interact with Otes:
- Alpelisib
- Seladelpar
- Talazoparib
- Topotecan
- Ubrogepant
Interactions may also occur with certain foods, alcohol, or tobacco—consult your doctor before changing your habits.
✔️ Do not use Otes if you have:
- Severe kidney or liver disease – use not recommended
- Pregnancy may harm the unborn baby
- Lactation – safety unknown
- Fertile females – contraindicated due to potential embryo-fetal toxicity
Regular check-ups and blood tests may be necessary during treatment.
✔️ Storage:
- Store at room temperature (20°C to 25°C)
- Keep away from heat, moisture, and light
- Do not freeze
- Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
