Terbiderm 250mg 10pcs
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Terbiderm 250mg 10pcs

Type: Tablet

Pack Size: 10 Pcs

Generic Name:Terbinafine 250mg

Orion Pharma Ltd.


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Discount Price: ৳ 470
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✅ Description:

Indications

Terbinafine tablet: This tablet is used to treat dermatophytes-caused onychomycosis of the toenail or fingernail (tinea unguium).

Tinea Capitis: Terbinafine granules are suggested.

Trichophyton (e.g. T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis, and Epidermophyton floccosum cause fungal infections of the skin. Yeast infections of the skin, mostly caused by the Candida genus (e.g. C. albicans). Due to Pityrosporum orbiculare, pityriasis (tinea) versicolor develops (also known as Malassezia furfur).

 

Pharmacology

Terbinafine, an antifungal Allylamine, inhibits the formation of Ergosterol (an important component of fungi cell membranes) by inhibiting the Squalene Epoxidase enzyme. This causes fungal cell death mostly due to increased membrane permeability caused by high levels of Squalene buildup, rather than Ergosterol insufficiency. Terbinafine hydrochloride may be fungicidal depending on the medication concentration and the fungus species tested in vitro. The clinical value of in vitro data, on the other hand, remains unknown. Terbinafine has been proven to be effective in vitro and in clinical infections against the majority of strains of the following microorganisms: Tricophyton Menta Tricophyton Menta Tricophyton Menta.

 

Dosage & Administration

Terbinafine tablet:

For the treatment of finger nail onychomycosis: Terbinafine 250 mg (one tablet), once daily for 6 weeks.

For the treatment of toenail onychomycosis: Terbinafine 250 mg (one tablet), once daily for 12 weeks.

The optimal clinical effect is seen some months after mycological cure and cessation of treatment. This is related to the period required for outgrowth of healthy nail.

Terbinafine granules:

Body Weight: <25 kg: 125 mg/day up to 6 weeks

Body Weight: 25-35 kg: 187.5 mg/day up to 6 weeks

Body Weight: >35 kg: 250 mg/day up to 6 weeks

Terbinafine cream: Terbinafine cream can be applied once or twice daily. Cleanse and dry the affected areas thoroughly before application of the terbinafine cream. Apply the cream to the affected skin and the surrounding area in a thin layer and rub in lightly. In the case of intertriginous infections (submammary, interdigital, intergluteal, inguinal) the application may be covered with a gauze strip, especially at night. The likely durations of treatment are as follows:

Tinea corporis, cruris: 1 to 2 weeks

Tinea pedis: 1 week

Cutaneous candidiasis: 2 weeks

Pityriasis versicolor: 2 weeks

Relief of the clinical symptoms usually occurs within a few days. Irregular use or premature discontinuation of treatment carries the risk of recurrence. If there are no signs of improvement after two weeks, the diagnosis should be verified.

 

Interaction

Terbinafine inhibits the CYP450 2D6 isozyme in vivo, according to research. Tricyclic antidepressants, selective serotonin reuptake inhibitors, beta-blockers, antiarrhythmics class 1C (e.g., flecainide and propafenone), and monoamine oxidase inhibitors Type B are among the drugs processed mostly by the CYP450 2D6 isozyme. Co-administration of terbinafine should be done with caution, and the dose of the 2D6-metabolized medication may need to be reduced.

 

Contraindications

Terbinafine tablets and cream are not recommended for people who are hypersensitive to terbinafine.

 

Side Effects

Gastrointestinal symptoms (including diarrhea, dyspepsia, and stomach discomfort), liver test abnormalities, rashes, urticaria, itching, and taste alterations are among the side effects recorded. In general, the side effects were minor and temporary, and they did not necessitate stopping the medication. Idiosyncratic and symptomatic hepatic injury, and more rarely, cases of liver failure, some resulting to death or liver transplant, serious skin responses, severe neutropenia, thrombocytopenia, angioedema, and allergic reactions, according to worldwide experience with terbinafine use (including anaphylaxis).

 

Pregnancy & Lactation

Terbinafine tablet: In pregnant women, there are no sufficient and well-controlled trials. Terbinafine should not be started during pregnancy since animal reproduction studies are not necessarily predictive of human response, and onychomycosis treatment can be postponed until after the pregnancy has finished. Terbinafine is found in the breast milk of nursing women after oral dosing. Terbinafine is not advised for use in breastfeeding mothers.ropose no unfavorable impacts. There's no clinical encounter with terbinafine in pregnant ladies; in this manner, unless the potential benefits exceed any potential hazard, terbinafine ought to not be managed. Terbinafine is excreted in the breast drain and thus moms ought to not get terbinafine treatment while breastfeeding.

Terbinafine cream: Animal toxicology and fertility tests show no negative effects on the fetus. There is no clinical experience with terbinafine in pregnant women; consequently, terbinafine should not be used unless the possible benefits outweigh the potential risks. Terbinafine is secreted in breast milk, so mothers who are breastfeeding should avoid terbinafine medication.

 

Precautions & Warnings

Warnings-

Terbinafine tablets: uncommon cases of liver disappointment, a few driving to passing or liver transplant, have happened with the utilize of terbinafine tablets for the treatment of onychomycosis in people with and without preexisting liver malady. Within the lion's share of liver cases detailed in affiliation with terbinafine utilize, the patients had genuine fundamental systemic conditions and a dubious causal affiliation with terbinafine. The seriousness of hepatic occasions and/or their result may be more awful in patients with dynamic or constant liver illness. Treatment with terbinafine tablets should be suspended on the off chance that there's biochemical or clinical prove of liver harm. There have been disconnected reports of genuine skin response (e.g., Stevens-Johnson Disorder and poisonous epidermal necrolysis). On the off chance that dynamic skin hasty happens, treatment with terbinafine ought to be ceased.

Terbinafine cream: Terbinafine cream should only be used on the outside of the body. Avoid coming into contact with the eyes.

Precautions:

Terbinafine is not indicated for persons with active or chronic liver disease. Pre-existing liver disease should be evaluated before Terbinafine is prescribed. Hepatotoxicity can affect persons with or without a history of liver disease. Before using terbinafine tablets, all patients should have their serum transaminase (ALT and AST) levels tested.

Storage Conditions

Store in a cool and dry place, below 30°C, and protect from light.

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