Tericin IV Injection | Amphotericin B | ePharma
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Tericin IV Injection

Generic: Amphotericin B

Type: Injection

Pack Size: 50ml

Amphotericin B is indicated for the following purposes:

  • Empirical Therapy in Febrile, Neutropenic Patients: It is used as an initial treatment for suspected fungal infections in febrile patients with low white blood cell counts (neutropenia).
  • Cryptococcal Meningitis in HIV-Infected Patients: It is used to treat Cryptococcal meningitis, a fungal infection of the membranes covering the brain and spinal cord, in patients with HIV infection.
  • Refractory Infections: Amphotericin B is used to treat infections caused by Aspergillus species, Candida species, and/or Cryptococcus species that are unresponsive to treatment with conventional amphotericin B deoxycholate. It may also be used when renal impairment or unacceptable toxicity prevents the use of amphotericin B deoxycholate.
  • Visceral Leishmaniasis: It is used in the treatment of visceral leishmaniasis, a parasitic infection affecting internal organs. Amphotericin B may be used in immunocompromised patients with visceral leishmaniasis.

Note: In immunocompromised patients with visceral leishmaniasis treated with Amphotericin B, relapse rates were high following initial clearance of parasites. This indicates the need for close monitoring and potential additional treatments to prevent relapse.


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Discount Price: ৳ 14142.3
MRP: ৳ 15045 6% Off

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✅ Description:

Tericin IV Injection contains Amphotericin B, which is classified as an Anti-fungal agent. It is prescribed to treat invasive fungal infections in patients who do not respond well to regular Amphotericin B treatment.

Tericin IV Injection is not suitable for individuals who are allergic to Amphotericin B. It should also not be used for common or superficial fungal infections that can only be detected through positive skin or serologic tests.

Prior to receiving Tericin IV Injection, inform your doctor if you have a low white blood cell count (neutropenia), liver problems (such as hepatic impairment), or kidney problems and are undergoing dialysis.

Pregnant and breastfeeding women should use Tericin IV Injection with caution only if it is absolutely necessary, and its use in children, adolescents (under 18 years), and elderly individuals (above 65 years) should be discussed with a doctor.

The most frequently reported side effects of Tericin IV Injection include fever, chills, and/or rigors. If any of these symptoms worsen, it is advisable to consult your doctor.

Safety Advices


Alcohol
UNSAFE

There is limited information available on the interaction of alcohol with Tericin IV Injection. Ask your doctor for advice on alcohol intake along with this medicine.


Pregnancy
SAFE IF PRESCRIBED

Tericin IV Injection should be administered with caution in pregnant women only if it is clearly necessary. Consult your doctor before receiving the medicine.


Breastfeeding
CONSULT YOUR DOCTOR

Tericin IV Injection should be administered with caution in breastfeeding women only if it is clearly necessary. Consult your doctor before receiving the medicine.


Driving
UNSAFE

is unlikely to affect your ability to drive/operate machines.  Consult your doctor before receiving Tericin IV Injection.


Kidney
SAFE IF PRESCRIBED

Tericin IV Injection should be administered with caution in patients with kidney disease and in patients who are under dialysis.  Consult your doctor before receiving the medicine.


Liver
CONSULT YOUR DOCTOR

Tericin IV Injection should be administered with caution in patients with hepatic impairment, and/or other liver disease. Consult your doctor before receiving Tericin IV Injection.

Similar Products

✔️ Uses of Tericin IV Injection
  • Severe Fungal Infections
✔️ How does Tericin IV Injection work?

Tericin IV Injection binds to ergosterol (steroid present on the cell membranes of fungi) which leads to the formation of pores and ion leakage on the cell membrane resulting in fungal cell death thus treating invasive fungal infections in affected individuals.

✔️ Side Effects of Tericin IV Injection
  • Injection site reactions (pain, swelling, redness)
  • Nausea
  • Vomiting
  • Chills
  • Headache
  • Anemia (low number of red blood cells)
  • Decreased potassium level in the blood
  • Abnormal liver function tests
  • Decreased magnesium level in blood
  • Diarrhea
  • Decreased appetite
  • Hypotension (low blood pressure)
  • Skin rash
  • Nephrocalcinosis
  • Increased creatinine level in blood
  • Abnormal renal function tests
  • Renal tubular acidosis
✔️ Quick Suggestions:
  • It is usually given as an injection over 1-2 hours under the supervision of a medical professional.
  • Tericin IV Injection can cause rash, chills, headache, and tiredness during the initial days of the treatment, but these may fade away with time.
  • Your doctor may ask you for regular blood tests to monitor your blood sugar, potassium, magnesium, and kidney function.
  • Inform your doctor immediately if you notice pain or blood upon urination, swelling of the face, and trouble breathing.
  • Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.
✔️ Indication of Tericin IV Injection
  • Treats invasive fungal infections in patients who are resistant/intolerant to conventional Amphotericin B therapy
✔️ Pharmacology

Amphotericin B is a polyene antifungal antibiotic that works by binding to ergosterol in the cell membrane of fungi. This alters the permeability of the membrane, causing leakage of cell components and leading to fungal cell death. It is effective against various fungal species, including Candida, Aspergillus, Cryptococcus, and others mentioned in the provided list.

✔️ Dosage & Administration of Tericin IV Injection

Dosage regimens for amphotericin B (conventional) for different routes of administration and indications are as follows:

  1. Oral Candidiasis (PO):
  • Each lozenge contains 10 mg of amphotericin B.
  • Suck 1 lozenge four times a day. If necessary, the dose can be increased up to 8 lozenges per day.
  1. Systemic Fungal Infections (IV):
  • Test Dose: Administer a one-time IV dose of 1 mg infused over 20-30 minutes.
  • Loading Dose: Administer a loading dose of 0.25-0.5 mg per kilogram of body weight infused over 2-6 hours.
  • Maintenance Dose: Administer a maintenance dose of 0.25-1 mg per kilogram of body weight once daily (day) or up to 1.5 mg per kilogram of body weight once every other day (EOD). The maintenance dose can be gradually increased by 0.25 mg increments per day.

Administration:

  • Increased toxicity may occur when amphotericin B is used with flucytosine.
  • Drug-induced renal toxicity can be enhanced in the presence of other nephrotoxic medications.
  • Amphotericin B may antagonize the effects of azole antifungals.
  • Potentially fatal interactions: Amphotericin B can potentiate potassium loss caused by corticosteroids. It should be avoided with diuretics. It can enhance digitalis toxicity and the effects of neuromuscular blockers.

Additional Considerations:

  • Adjustments in dosage may be necessary for patients with renal or hepatic impairment. Close monitoring of renal and liver function is important.
  • In pregnant patients, the risks and benefits of using amphotericin B should be carefully considered.
  • The excretion of amphotericin B in breast milk is unknown. Due to the potential for serious adverse reactions in breastfed infants, a decision should be made whether to discontinue nursing or the drug, taking into account its importance to the mother.

Tericin IV Injection will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

✔️ Interaction

Nephrotoxic drugs: These are medications that can potentially cause kidney damage. Examples include aminoglycosides (e.g., gentamicin, tobramycin) and cisplatin. It is important to disclose the use of these drugs to your doctor, as combining them with Tericin IV Injection may increase the risk of kidney problems.

Zidovudine: This medication is used in the treatment of HIV. It is essential to inform your doctor if you are taking zidovudine, as there may be interactions between zidovudine and Tericin IV Injection. Your doctor will evaluate the potential risks and benefits of combining these medications.

Cyclosporin: Cyclosporin is used to prevent rejection of transplanted organs. If you are taking cyclosporin, it is important to discuss this with your doctor before receiving Tericin IV Injection. There may be interactions between these medications, and your doctor will monitor you closely for any potential adverse effects.

✔️ Contraindications

You are allergic to netilmicin or other aminoglycosides or any of the other ingredients of Netmicin Injection.

✔️ Pregnancy & Lactation

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

✔️ Precautions & Warnings
  • Allergies: Inform your doctor or pharmacist if you have any allergies to amphotericin B or any other substances. This medication may contain inactive ingredients that could cause allergic reactions or other complications. Discuss your allergies with your pharmacist for further information.
  • Medical history: Share your complete medical history with your doctor or pharmacist, especially if you have a history of white blood cell (leukocyte) transfusions, heart disease (such as irregular heartbeat or congestive heart failure), liver disease, or kidney disease. These conditions may influence the use and dosage adjustments of amphotericin B.
  • Pregnancy: During pregnancy, the use of amphotericin B should only be considered if the potential benefits outweigh the risks. It is important to have a discussion with your doctor regarding the risks and benefits of using the medication during pregnancy.
  • Breastfeeding: It is unknown whether amphotericin B passes into breast milk. Consult your doctor before breastfeeding while using this medication to assess the potential risks and benefits.
✔️ Storage Conditions

Store in a refrigerator (2 - 8°C). Do not freeze.

Frequently Asked Questions (FAQ)

Tericin IV Injection is an anti-fungal agent which is used to treat invasive fungal infections in patients who are resistant/intolerant to conventional Amphotericin B therapy.

Yes, Tericin IV Injection can be administered but with caution in pregnant and breastfeeding women. Consult your doctor before receiving the medicine.

Yes, Tericin IV Injection is an antifungal antibiotic used to treat serious fungi infections such as fungal infections of one or more deep organs of the body, suspected fungal infections in patients with a high fever and neutropenia (a low number of white blood cells [neutrophils]), and Visceral leishmaniasis (a parasitic disease).

Tericin IV Injection is either administered as intravenous injection or infusion by a registered medical professional only

The most common side effects of receiving Tericin IV Injection are fever, chills, and/or rigors. Consult your doctor if any of these symptoms worsen.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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