Amphotericin B is indicated for the following purposes:
Note: In immunocompromised patients with visceral leishmaniasis treated with Amphotericin B, relapse rates were high following initial clearance of parasites. This indicates the need for close monitoring and potential additional treatments to prevent relapse.
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Tericin IV Injection contains Amphotericin B, which is classified as an Anti-fungal agent. It is prescribed to treat invasive fungal infections in patients who do not respond well to regular Amphotericin B treatment.
Tericin IV Injection is not suitable for individuals who are allergic to Amphotericin B. It should also not be used for common or superficial fungal infections that can only be detected through positive skin or serologic tests.
Prior to receiving Tericin IV Injection, inform your doctor if you have a low white blood cell count (neutropenia), liver problems (such as hepatic impairment), or kidney problems and are undergoing dialysis.
Pregnant and breastfeeding women should use Tericin IV Injection with caution only if it is absolutely necessary, and its use in children, adolescents (under 18 years), and elderly individuals (above 65 years) should be discussed with a doctor.
The most frequently reported side effects of Tericin IV Injection include fever, chills, and/or rigors. If any of these symptoms worsen, it is advisable to consult your doctor.
There is limited information available on the interaction of alcohol with Tericin IV Injection. Ask your doctor for advice on alcohol intake along with this medicine.
Tericin IV Injection should be administered with caution in pregnant women only if it is clearly necessary. Consult your doctor before receiving the medicine.
Tericin IV Injection should be administered with caution in breastfeeding women only if it is clearly necessary. Consult your doctor before receiving the medicine.
is unlikely to affect your ability to drive/operate machines. Consult your doctor before receiving Tericin IV Injection.
Tericin IV Injection should be administered with caution in patients with kidney disease and in patients who are under dialysis. Consult your doctor before receiving the medicine.
Tericin IV Injection should be administered with caution in patients with hepatic impairment, and/or other liver disease. Consult your doctor before receiving Tericin IV Injection.
Tericin IV Injection binds to ergosterol (steroid present on the cell membranes of fungi) which leads to the formation of pores and ion leakage on the cell membrane resulting in fungal cell death thus treating invasive fungal infections in affected individuals.
Amphotericin B is a polyene antifungal antibiotic that works by binding to ergosterol in the cell membrane of fungi. This alters the permeability of the membrane, causing leakage of cell components and leading to fungal cell death. It is effective against various fungal species, including Candida, Aspergillus, Cryptococcus, and others mentioned in the provided list.
Dosage regimens for amphotericin B (conventional) for different routes of administration and indications are as follows:
Administration:
Additional Considerations:
Tericin IV Injection will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Nephrotoxic drugs: These are medications that can potentially cause kidney damage. Examples include aminoglycosides (e.g., gentamicin, tobramycin) and cisplatin. It is important to disclose the use of these drugs to your doctor, as combining them with Tericin IV Injection may increase the risk of kidney problems.
Zidovudine: This medication is used in the treatment of HIV. It is essential to inform your doctor if you are taking zidovudine, as there may be interactions between zidovudine and Tericin IV Injection. Your doctor will evaluate the potential risks and benefits of combining these medications.
Cyclosporin: Cyclosporin is used to prevent rejection of transplanted organs. If you are taking cyclosporin, it is important to discuss this with your doctor before receiving Tericin IV Injection. There may be interactions between these medications, and your doctor will monitor you closely for any potential adverse effects.
You are allergic to netilmicin or other aminoglycosides or any of the other ingredients of Netmicin Injection.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Store in a refrigerator (2 - 8°C). Do not freeze.
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