Voricare 50 Tablet 1 Strip

✔️ Dosage & Administration of Voricare 50

Oral Use

Take at least 1 hour before or after meals.

≥40 kg body weight

• Loading: 400 mg (10 ml) every 12 hours for the first 24 hours
• Maintenance: 200 mg (5 ml) twice daily

<40 kg body weight

• Loading: 200 mg (5 ml) every 12 hours for the first 24 hours
• Maintenance: 100 mg (2.5 ml) twice daily

Children under 12: Safety and efficacy not established

✔️ Drug Interactions

Enzyme Modulators: Voricare’s efficacy and toxicity may be altered by CYP3A4, CYP2C9, and CYP2C19 inhibitors or inducers. Dose adjustments and close monitoring are advised.

Other Drug Interactions:

May raise levels of CYP3A4, CYP2C9, and CYP2C19 substrates; dose reduction of those drugs may be necessary.

Phenytoin or Efavirenz co-administration may require increased Voricare dosing.

✔️ Contraindications

• Known hypersensitivity to voriconazole or formulation components
• Concurrent use with the following due to risk of serious adverse effects:
• Terfenadine, astemizole, cisapride, pimozide, quinidine, sirolimus
• Rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids, and St. John's Wort

✔️ Side Effects of Voricare 50

Common adverse effects may include:

• Abdominal pain, nausea, diarrhea
• Headache, blurred vision, chest pain
• Anemia

✔️ Use During Pregnancy & Lactation

Voricare should be used during pregnancy only if the potential benefits outweigh the risks, as adequate human data is lacking. Caution is advised during lactation.

✔️ Precautions & Warnings

Long-term therapy (over 180 days) requires risk-benefit reassessment due to potential risks, including squamous cell carcinoma of the skin (SCC).

Monitor liver function and visual changes during prolonged therapy.

✔️ Storage

• Store below 25°C in a dry, light-protected place.
• For powder for suspension: Store between 2°C–8°C prior to reconstitution.
• Keep out of reach of children.