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Voricare 50 Tablet 1 Strip
Voriconazole, a triazole antifungal, acts by inhibiting fungal ergosterol synthesis. It specifically targets the CYP450-dependent enzyme 14-α-sterol demethylase, leading to reduced ergosterol in the fungal cell membrane, thereby compromising membrane integrity and exerting its antifungal effect.
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✅ Description:
Voricare is a broad-spectrum triazole antifungal indicated for patients aged 12 years and older for the treatment of:
- Invasive aspergillosis
- Candidemia (in nonneutropenic patients) and deep-seated Candida infections in the skin, abdomen, kidneys, bladder wall, and surgical wounds
- Esophageal candidiasis
- Severe infections caused by Scedosporium apiospermum and Fusarium species, including Fusarium solani
- Patients unresponsive to or intolerant of other antifungal therapies
Use only as directed by a registered physician.
Safety Advices
Alcohol
UNSAFE
It is unsafe to consume alcohol with Voricare 50.
Pregnancy
CAUTION
Voricare 50 is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, please consult your doctor before taking it. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with Voricare 50.
Breastfeeding
CAUTION
Voricare 50 should be used with caution in breastfeeding women. Consult your doctor before taking it.
Driving
UNSAFE
Do not drive or operate any machines if you experience vision problems after taking Voricare 50.
CONSULT YOUR DOCTOR
Voricare 50 should be used with caution in patients with kidney disease. Consult your doctor before taking it.
CONSULT YOUR DOCTOR
Voricare 50 should be used with caution in patients with liver problems. Consult your doctor before taking it.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration of Voricare 50
Oral Use
Take at least 1 hour before or after meals.
≥40 kg body weight
- Loading: 400 mg (10 ml) every 12 hours for the first 24 hours
- Maintenance: 200 mg (5 ml) twice daily
<40 kg body weight
- Loading: 200 mg (5 ml) every 12 hours for the first 24 hours
- Maintenance: 100 mg (2.5 ml) twice daily
Children under 12: Safety and efficacy not established
✔️ Drug Interactions
Enzyme Modulators: Voricare’s efficacy and toxicity may be altered by CYP3A4, CYP2C9, and CYP2C19 inhibitors or inducers. Dose adjustments and close monitoring are advised.
Other Drug Interactions:
May raise levels of CYP3A4, CYP2C9, and CYP2C19 substrates; dose reduction of those drugs may be necessary.
Phenytoin or Efavirenz co-administration may require increased Voricare dosing.
✔️ Contraindications
- Known hypersensitivity to voriconazole or formulation components
- Concurrent use with the following due to risk of serious adverse effects:
- Terfenadine, astemizole, cisapride, pimozide, quinidine, sirolimus
- Rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids, and St. John's Wort
✔️ Side Effects of Voricare 50
Common adverse effects may include:
- Abdominal pain, nausea, diarrhea
- Headache, blurred vision, chest pain
- Anemia
✔️ Use During Pregnancy & Lactation
Voricare should be used during pregnancy only if the potential benefits outweigh the risks, as adequate human data is lacking. Caution is advised during lactation.
✔️ Precautions & Warnings
Long-term therapy (over 180 days) requires risk-benefit reassessment due to potential risks, including squamous cell carcinoma of the skin (SCC).
Monitor liver function and visual changes during prolonged therapy.
✔️ Storage
- Store below 25°C in a dry, light-protected place.
- For powder for suspension: Store between 2°C–8°C prior to reconstitution.
- Keep out of reach of children.
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