Voriconazole | Azole Antifungal
Available as: Tablets, Oral Suspension, and Injection
For patients ≥12 years
Voriconazole is a broad-spectrum triazole antifungal that inhibits fungal ergosterol synthesis, an essential component of the fungal cell membrane. It acts through inhibition of CYP450-dependent 14-alpha sterol demethylase, resulting in cell membrane dysfunction and fungal death.
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Voriderm is indicated in the treatment of serious and potentially life-threatening fungal infections, including:
Pregnancy: Use only if clearly needed. May pose fetal risks (category not explicitly defined).
Lactation: Use only when benefits outweigh risks.
Children <12 years: Safety and efficacy not established.
Elderly: No dosage adjustment necessary unless liver/renal impairment is present.
To be taken 1 hour before or after meals
≥40 kg body weight
Loading dose: 400 mg (10 ml) every 12 hours for the first 24 hours
Maintenance dose: 200 mg (5 ml) twice daily
<40 kg body weight
Loading dose: 200 mg (5 ml) every 12 hours for the first 24 hours
Maintenance dose: 100 mg (2.5 ml) twice daily
Or as prescribed by a registered physician
Gastrointestinal: Nausea, abdominal pain, diarrhea
Visual disturbances: Blurred vision
Nervous system: Headache
Others: Anemia, chest pain
Known hypersensitivity to voriconazole or any component
Concurrent use of medications listed above may cause life-threatening adverse reactions
Use with caution in long-term therapy (≥180 days); increased risk of cutaneous squamous cell carcinoma (SCC) has been reported.
Regular monitoring of liver function, visual disturbances, and dermatologic reactions is advised.
Adjust dose and monitor with CYP-metabolized drugs.
Use caution in hepatic and renal dysfunction.
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.