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Mesacol 400 contains mesalazine (also called mesalamine or 5-aminosalicylic Acid) as its active ingredient. It is used to treat:
- Ulcerative colitis is characterized by inflammation and ulcers in the lining of the large intestine.
- Prevention of recurrence of symptoms associated with ulcerative colitis.
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✅ Description:
Mesacol 400 mg Tablet is used for the treatment of mild to moderate ulcerative colitis, a condition that causes swelling and sores in the lining of the colon (large intestine) and rectum. It helps relieve symptoms such as rectal bleeding, diarrhea, and stomach discomfort by inhibiting the production of substances that cause inflammation.
- The dosage depends on the severity of the condition. For adults, the dosage can be up to 4 gm mesalamine once daily or divided into 2-4 doses for active disease, and 2 gm mesalamine once daily for maintenance treatment.
- Mesacol 400 mg Tablet should be taken with food to avoid stomach discomfort. It is important to take this medicine at the same time every day to maintain a consistent level in your body. Do not stop taking this medicine without consulting your doctor, as your symptoms could reoccur.
- Be cautious if taking other nephrotoxic agents such as NSAIDs and Azathioprine, as they may increase the risk of renal reactions.
Safety Advices
Alcohol
UNSAFE
Interaction with alcohol is unknown.
Pregnancy
CONSULT YOUR DOCTOR
Consult your doctor before taking this medicine if you are pregnant
Breastfeeding
CONSULT YOUR DOCTOR
Consult your doctor before taking this medicine if you are breastfeeding.
Driving
CAUTION
Avoid driving vehicles and operating machines as Mesacol 400 mg Tablet may make you feel dizzy.
Kidney
CAUTION
Use with caution if you have a history of kidney or liver disease. Regular monitoring of renal function and liver enzymes is recommended.
Liver
CAUTION
Use with caution if you have a history of kidney or liver disease. Regular monitoring of renal function and liver enzymes is recommended.
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✔️ Uses of Mesacol 400mg Tablet
- Ulcerative Colitis
✔️ How does Mesacol work to alleviate symptoms of inflammatory bowel disease?
Mesalamine, the active ingredient in Mesacol, appears to work topically in the colon rather than systemically. It reduces inflammation by blocking the production of arachidonic acid metabolites through cyclooxygenase pathways (prostaglandins) and lipoxygenase pathways (leukotrienes and hydroxy eicosatetraenoic acids). This helps to diminish inflammation associated with chronic inflammatory bowel diseases.
✔️ Side Effectsmof Mesacol 400mg Tablet
- Nausea
- Vomiting
- Headache
- Dizziness
- Asthenia (weakness)
- Dyspepsia (indigestion)
- Pruritus (itching)
✔️ Quick Suggestions:
- Mesacol 400 tablet should be taken as directed by your doctor. Swallow it whole with a glass of water, preferably before your meals.
- Do not cut, break, or chew the medicine. It would be best if you took it at a fixed time for optimal results and should not consume it more than that prescribed by your doctor.
- Seek urgent medical help if you feel that you have taken too much of Mesacol 400mg Tablet
- In case you’ve missed any dose, take it as soon as you remember it. If it is almost time for the next dose, then skip the missed dose.
- Avoid taking a double dose to compensate for the missed dose.
✔️ Indications:
Mesacol 400 Tablet is used in treating ulcerative colitis (a condition that causes inflammation, irritation, and ulcers in your digestive tract preferably the lining of your large intestine). It is also used in preventing symptoms like diarrhea, stomach pain, and bleeding from recurring.
✔️ Pharmacology
The mechanism of action of Mesalamine is unknown but appears to be topical rather than systemic. Mucosal production of Arachidonic Acid metabolites, both through the cyclooxygenase pathways, that is, prostanoids, and through the lipoxygenase pathways, that is, leukotrienes and hydroxy eicosatetraenoic acids, is increased in patients with chronic inflammatory bowel disease. Mesalamine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.
✔️ Dosage & Administration of Mesacol 400mg Tablet
- For Adults with Ulcerative Colitis:
- Active disease: Up to 4 g mesalazine once daily or divided into 2-4 doses.
- Maintenance treatment: 2 g mesalazine once daily.
- For Children 6 years and older:
- Active disease: Start with 30-50 mg/kg/day in divided doses. Maximum dose: 75 mg/kg/day in divided doses, not exceeding 4 g/day.
- Maintenance treatment: Start with 15-30 mg/kg/day in divided doses, not exceeding 2 g/day.
Safety and efficacy in children below 6 years of age have not been established.
✔️ Interaction
Concurrent use with other nephrotoxic agents such as NSAIDs and Azathioprine may increase the risk of renal reactions.
✔️ Contraindications
Hypersensitivity to salicylates or any other component of the formulation.
✔️ Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised when administering to a nursing mother.
✔️ Precautions & Warnings
- Not recommended for use in children below 6 years old.
- Caution should be exercised in patients with renal dysfunction or a history of renal disease. Regular monitoring of renal function is advised.
- Patients with liver impairment should use this medication with caution.
- Patients with pyloric stenosis may experience delayed release of the drug in the colon.
✔️ Storage Conditions:
- Store below 30°C.
- Protect from light and moisture.
- Keep all medicines out of the reach of children.
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here information is for informational purposes only.
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and discuss all your queries related to any disease or medicine. We
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