Mesacol 400mg Tablet 10pcs

Uses of Mesacol 400mg Tablet

• Ulcerative Colitis

How does Mesacol work to alleviate symptoms of inflammatory bowel disease?

Mesalamine, the active ingredient in Mesacol, appears to work topically in the colon rather than systemically. It reduces inflammation by blocking the production of arachidonic acid metabolites through cyclooxygenase pathways (prostaglandins) and lipoxygenase pathways (leukotrienes and hydroxy eicosatetraenoic acids). This helps to diminish inflammation associated with chronic inflammatory bowel diseases.

Side Effectsmof Mesacol 400mg Tablet

• Nausea
• Vomiting
• Headache
• Dizziness
• Asthenia (weakness)
• Dyspepsia (indigestion)
• Pruritus (itching)

Quick Suggestions:

• Mesacol 400 tablet should be taken as directed by your doctor. Swallow it whole with a glass of water, preferably before your meals.
• Do not cut, break, or chew the medicine. It would be best if you took it at a fixed time for optimal results and should not consume it more than that prescribed by your doctor.
• Seek urgent medical help if you feel that you have taken too much of Mesacol 400mg Tablet
• In case you’ve missed any dose, take it as soon as you remember it. If it is almost time for the next dose, then skip the missed dose.
• Avoid taking a double dose to compensate for the missed dose.

Indications:

Mesacol 400 Tablet is used in treating ulcerative colitis (a condition that causes inflammation, irritation, and ulcers in your digestive tract preferably the lining of your large intestine). It is also used in preventing symptoms like diarrhea, stomach pain, and bleeding from recurring.

Pharmacology

The mechanism of action of Mesalamine is unknown but appears to be topical rather than systemic. Mucosal production of Arachidonic Acid metabolites, both through the cyclooxygenase pathways, that is, prostanoids, and through the lipoxygenase pathways, that is, leukotrienes and hydroxy eicosatetraenoic acids, is increased in patients with chronic inflammatory bowel disease. Mesalamine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.

Dosage & Administration of Mesacol 400mg Tablet

• For Adults with Ulcerative Colitis:
  • Active disease: Up to 4 g mesalazine once daily or divided into 2-4 doses.
  • Maintenance treatment: 2 g mesalazine once daily.
• For Children 6 years and older:
  • Active disease: Start with 30-50 mg/kg/day in divided doses. Maximum dose: 75 mg/kg/day in divided doses, not exceeding 4 g/day.
  • Maintenance treatment: Start with 15-30 mg/kg/day in divided doses, not exceeding 2 g/day.

Safety and efficacy in children below 6 years of age have not been established.

Interaction

Concurrent use with other nephrotoxic agents such as NSAIDs and Azathioprine may increase the risk of renal reactions.

Contraindications

Hypersensitivity to salicylates or any other component of the formulation.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised when administering to a nursing mother.

Precautions & Warnings

• Not recommended for use in children below 6 years old.
• Caution should be exercised in patients with renal dysfunction or a history of renal disease. Regular monitoring of renal function is advised.
• Patients with liver impairment should use this medication with caution.
• Patients with pyloric stenosis may experience delayed release of the drug in the colon.

Storage Conditions:

• Store below 30°C.
• Protect from light and moisture.
• Keep all medicines out of the reach of children.