Pentasa Microgranules 2gm Sachet

✔️ Common side effects include:

• Headache
• Nausea
• Dizziness
• Weakness (asthenia)
• Indigestion (dyspepsia)
• Vomiting
• Itching (pruritus)

✔️ Dosage & Administration

Tablet Dose:

Treatment of mild to moderate Ulcerative Colitis

Adults: 800 mg (two 400 mg tablets) three times daily for 6 weeks. The dose may be increased up to 4.8 g/day in divided doses if necessary.

Children (5 years and older):

• Weight 17 to <33 kg: Morning - two 400 mg tablets; Evening - one 400 mg tablet (6 weeks)
• Weight 33 to <54 kg: Morning - three 400 mg tablets; Evening - two 400 mg tablets

Maintenance of remission in mild to moderate Ulcerative Colitis

• Adults: 1.6 g (four 400 mg tablets) daily in two to four divided doses. Dose may be increased to 2.4 g/day if needed.

Maintenance of remission in Crohn’s Disease

• Adults: 1.2–2.4 g daily in divided doses.
• Children: 400–800 mg three times daily.

Prolonged Release Granules Dose:

Treatment of Ulcerative Colitis:

Adults:

• Active disease: Up to 4 g once daily or divided into 2–4 doses.
• Maintenance: 2 g once daily.

Pediatric (6 years and older):

• Active disease: 30–50 mg/kg/day in divided doses, up to 75 mg/kg/day. Maximum dose: 4 g/day.
• Maintenance: 15–30 mg/kg/day, not exceeding 2 g/day.

Note: The granules must not be chewed. The contents can be emptied onto the tongue and swallowed with water or orange juice, or mixed with yogurt and consumed immediately.

✔️ Uses of Pentasa

Treat ulcerative colitis

✔️ Overdose Effects

• There is no specific antidote for Mesalamine overdose. Treatment is supportive and may include:
• Preventing further gastrointestinal absorption
• Correcting fluid and electrolyte imbalances
• Maintaining renal function
• As this is a pH-dependent delayed-release product, this factor should be considered when treating an overdose.

✔️ Geriatric patients (65 years and older):

Blood cell counts should be monitored closely. Since renal function may decrease with age, it is recommended to evaluate renal function before starting Mesalamine and monitor it throughout therapy.

✔️ Pediatric:

Safety and effectiveness in children under 6 years have not been established.

✔️ Liver impairment:

There have been reports of liver failure in patients with pre-existing liver conditions. Caution is advised when administering Mesalamine to such patients.

✔️ Pregnancy & Lactation

Mesalamine should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Caution is advised for nursing mothers.

✔️ Pyloric stenosis:

Patients may experience delayed gastric emptying, which can delay Mesalamine release in the colon.

✔️ Renal impairment:

Cases of nephropathy and interstitial nephritis have been reported. Renal function should be checked before starting treatment and monitored periodically.

✔️ Storage Conditions

Store below 30°C. Protect from light and moisture. Keep all medicines out of reach of children.