Maxpro 40mg Capsule

✔️ Uses of Maxpro 40 Capsule

• Gastroesophageal reflux disease (Acid reflux)
• Peptic ulcer disease

✔️ How does Maxpro 40 Capsule work?

Maxpro 40 Capsule is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of enzymes in the stomach cell. It hence reduces gastric acidity by blocking the final step in acid production and helps in the relief of acid-related indigestion and heartburn.

✔️ Side Effects of Maxpro 40mg Capsule

• Headache
• Dizziness
• Dryness in mouth
• Nausea
• Abdominal pain
• Constipation
• Flatulence
• Diarrhea
• Arthralgia (joint pain)
• Stomach pain
• Skin rash
• Difficulty in breathing
• Swelling of face, lips, eyelids, tongue, hands and feet
• Irregular heartbeat
• Decreased appetite

✔️ Quick Suggestions:

• To minimize the occurrence of acid reflux or heartburn, it is advisable to avoid consuming foods or drinks that can trigger these symptoms. This includes onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes, as well as high-fat and spicy foods.
• Before going to bed, it is recommended to elevate the head of your bed so that your head and chest are positioned higher than your feet. Instead of using multiple pillows, using a single raised block should be sufficient. This elevation prevents stomach acid from flowing back into the esophagus.
• In addition, it is important to refrain from consuming alcohol and smoking cigarettes. Alcohol can stimulate the production of stomach acid, leading to heartburn and acid reflux. Smoking damages the valve (sphincter) that normally prevents the backflow of stomach acid into the esophagus.
• Incorporating high-fiber foods, berries, cherries, leafy green vegetables such as kale and spinach, and black peppers into your diet can be beneficial. These foods are rich in antioxidants, calcium, and vitamin B12, which can help mitigate the potential long-term effects of medication. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics that aid in preventing excessive stomach acid production. Cranberry juice can also be beneficial for peptic ulcers and H. pylori infections.
• Avoid sitting for prolonged periods without breaks, as this can increase stomach acid production. Taking a five-minute break every hour to engage in brisk walking or stretching is recommended.

Maxpro 40mg Capsule is generally well-tolerated and provides long-lasting relief. However, there are certain healthy practices to prevent acidity:

• Limit consumption of carbonated beverages/soft drinks, citrus juices, fried food, and caffeinated beverages like tea and coffee.
• Avoid alcohol and smoking.
• Refrain from eating late at night or immediately before bedtime.
• Inform your doctor if you experience persistent watery diarrhea, fever, or stomach pain.

Long-term use of Maxpro 40mg Capsule may lead to weakened bones and deficiencies in minerals such as magnesium. It is important to ensure an adequate intake of calcium and magnesium through diet or prescribed supplements, as advised by your doctor.

If you develop symptoms such as decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, rash, or fever, it is essential to consult your doctor promptly, as these could be indications of a kidney problem.

Prolonged use of Maxpro 40mg Capsule has been associated with an increased risk of Clostridium difficile-associated diarrhea, as well as deficiencies in magnesium and vitamin B12, which can increase the risk of bone fractures. Atrophic gastritis (inflammation of the stomach lining) and acute interstitial nephritis (inflammation of kidney cells) are also potential risks.

✔️ Indications of Maxpro 40mg Capsule

Esomeprazole is not intended to provide fast relief from heartburn symptoms. Esomeprazole is a medication that is used to treat the symptoms of gastroesophageal reflux disease (GERD) and other disorders involving excess stomach acid, such as Zollinger-Ellison syndrome. Esomeprazole is also used to help repair erosive esophagitis. (damage to your esophagus caused by stomach acid).

Esomeprazole may also be used to prevent stomach ulcers caused by Helicobacter pylori infection or the use of nonsteroidal anti-inflammatory medications. (NSAIDs).

✔️ Pharmacology

The H+/K+ ATPase in the gastric parietal cell is inhibited by the proton pump inhibitor esomeprazole, which reduces the amount of stomach acid produced. Esomeprazole (omeprazole's S-isomer), the first proton pump inhibitor with a single optical isomer, offers better acid control than racemic proton pump inhibitors.

✔️ Dosage & Administration of Maxpro 40mg Capsule

Dosage recommendations for Esomeprazole in tablet or capsule form are as follows:

• Healing of erosive esophagitis: The recommended dosage is 20 mg or 40 mg once daily for 4 to 8 weeks. Most patients experience healing within this timeframe. If healing does not occur after 4 to 8 weeks, an additional 4 to 8 weeks of treatment may be considered.
• Maintenance of healing of erosive esophagitis: To maintain the healing of erosive esophagitis, a dosage of 20 mg once daily is recommended. Controlled studies have not extended beyond six months.
• Symptomatic GERD (gastroesophageal reflux disease): The recommended dosage is 20 mg once daily for 4 weeks. If symptoms do not completely resolve after 4 weeks, an additional 4 weeks of treatment may be considered.
• H. pylori eradication (Triple therapy): For the eradication of H. pylori bacteria, the recommended dosage is Esomeprazole 20 mg twice daily, Amoxicillin 1000 mg twice daily, and Clarithromycin 500 mg twice daily. This regimen should be taken for a duration of 10 days.

Esomeprazole Capsule should be swallowed whole and taken one hour before a meal. It is important to note that these dosage recommendations are provided as general guidelines. The actual dosage and duration of treatment may vary based on individual factors and should be determined by a healthcare professional.

✔️ Interaction

• Blood thinners (clopidogrel, warfarin): Maxpro 40mg Capsule may interact with these medications, potentially affecting their effectiveness or increasing the risk of bleeding. Close monitoring is necessary.
• Antifungal drugs (ketoconazole, voriconazole, itraconazole, posaconazole): These antifungal medications can increase the levels of Maxpro 40mg Capsule in the body, leading to a higher risk of side effects. Dose adjustments may be required.
• Anti-HIV drugs (atazanavir, nelfinavir, rilpivirine): Maxpro 40mg Capsule can interact with certain anti-HIV medications, potentially reducing their effectiveness. Your doctor may need to adjust the dosage or consider alternative treatment options.
• Anti-viral drug (nelfinavir): Maxpro 40mg Capsule may interact with nelfinavir, potentially affecting its absorption. It is important to consult with your doctor if you are taking both medications.
• Iron supplements: Maxpro 40mg Capsule can reduce the absorption of iron supplements, potentially leading to decreased effectiveness. It is advisable to take iron supplements at a different time than Maxpro 40mg Capsule.
• Antibiotic (ampicillin, rifampicin): These antibiotics can reduce the levels of Maxpro 40mg Capsule in the body, potentially reducing its effectiveness. Your doctor may need to adjust the dosage or consider alternative treatment options.
• Heart medicine (digoxin): Maxpro 40mg Capsule can interact with digoxin, potentially increasing the levels of digoxin in the body. Close monitoring of digoxin levels is necessary.
• Anti-cancer drug (methotrexate): Maxpro 40mg Capsule can increase the levels of methotrexate in the body, potentially leading to an increased risk of methotrexate-related side effects. Close monitoring is necessary.
• Additionally, Maxpro 40mg Capsule should not be given to patients with Clostridium difficile-associated diarrhea, magnesium, and vitamin B12 deficiency (which increases the risk of bone fracture), atrophic gastritis (inflammation of the stomach lining), or acute interstitial nephritis (inflammation of kidney cells).

✔️ Contraindications

Esomeprazole (the active ingredient in Maxpro 40mg Capsule) is contraindicated in patients who have a known hypersensitivity (allergy) to any component of the formulation or to substituted Benzimidazoles. Hypersensitivity reactions can vary in severity and may include symptoms such as rash, itching, swelling, severe dizziness, and difficulty breathing. If a patient has a known hypersensitivity to esomeprazole or related substances, alternative treatment options should be considered.

• Allergy or hypersensitivity to Maxpro 40mg Capsule or proton pump inhibitors.
• Gastric cancer.
• Liver disease.
• Low magnesium levels (osteoporosis).
• Low vitamin B12 levels.
• Pregnancy or planning for pregnancy.
• Breastfeeding mothers.

✔️ Pregnancy & Lactation

In pregnant women, there are no adequate and well-controlled considerations. Teratogenic effects have not been discovered in animal studies. Esomeprazole excretion in the drain has not been studied. Breastfeeding should thus be discontinued if the use of esomeprazole is thought to be essential.

✔️ Precautions & Warnings

• Maxpro 40mg Capsule should be avoided in individuals who are allergic to Maxpro 40mg Capsule or proton pump inhibitors, have gastric cancer, liver disease, low magnesium levels (associated with osteoporosis), low vitamin B12 levels, or are pregnant, planning for pregnancy, or breastfeeding.
• It is important to inform your doctor about any medications you are taking, including blood thinners (warfarin), antifungals (such as ketoconazole), anti-HIV drugs (atazanavir, nelfinavir), iron supplements, ampicillin antibiotics, and anti-cancer drugs (methotrexate), as these may interact with Maxpro 40mg Capsule
• Prolonged use of Maxpro 40mg Capsule may lead to conditions like lupus erythematosus, as well as deficiencies in vitamin B12 and magnesium.
• It is worth noting that the use of Maxpro 40mg Capsules may mask symptoms of gastric cancer, so if you experience severe stomach pain or gastric bleeding (blood in mucus or stool), it is important to consult your doctor immediately.

✔️ Storage Conditions

Store in a cool & dry place below 25ºC, and protect from light. Keep out of reach of children & pets.