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Nexcap 40mg Capsule 1 Strip
Esomeprazole, a proton pump inhibitor (PPI), reduces gastric acid production by inhibiting the H+/K+-ATPase enzyme in gastric parietal cells. It is the S-isomer of omeprazole, offering superior acid control compared to racemic PPIs.
- Absorption: Esomeprazole capsules are enteric-coated. Peak plasma levels occur approximately 1.5 hours after oral administration. Dose proportionality is observed, with a threefold increase in plasma concentration as dosage increases.
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✅ Description:
NexCap is prescribed for:
- Relief from chronic heartburn and other symptoms of GERD.
- Healing and maintenance of erosive esophagitis.
- Combination therapy with amoxicillin and clarithromycin for Helicobacter pylori eradication in duodenal ulcer patients.
- Zollinger-Ellison syndrome.
- Acid-related dyspepsia.
- Duodenal and gastric ulcers.
Use medication only as advised by a registered physician
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✔️ Dosage
- Healing of Erosive Esophagitis: 20-40 mg daily for 4-8 weeks. If not healed, an additional 4-8 weeks may be required.
- Maintenance of Healing: 20 mg daily (studied for up to 6 months).
- Symptomatic GERD: 20 mg daily for 4 weeks. Treatment can be extended by another 4 weeks if symptoms persist.
- H. pylori Eradication: 40 mg daily for 10 days with amoxicillin (1000 mg twice daily) and clarithromycin (500 mg twice daily).
- Zollinger-Ellison Syndrome: 20-80 mg daily, adjusted as necessary.
- Acid-related Dyspepsia: 20-40 mg daily for 2-4 weeks.
- Duodenal Ulcer: 20 mg daily for 2-4 weeks.
- Gastric Ulcer: 20-40 mg daily for 4-8 weeks.
✔️ Side Effects
Common side effects include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth. Long-term maintenance therapy shows no new adverse effects compared to short-term use.
✔️ Interactions
- Esomeprazole is metabolized by CYP2C19 and CYP3A4 but does not significantly interact with most drugs processed by these enzymes (e.g., phenytoin, warfarin, quinidine, clarithromycin, and amoxicillin).
- May affect the absorption of drugs dependent on gastric pH (e.g., ketoconazole, iron salts, and digoxin).
- Co-administration with oral contraceptives, diazepam, phenytoin, or quinidine does not alter its pharmacokinetics significantly.
- Combination therapy with clarithromycin and amoxicillin increases plasma levels of both esomeprazole and 14-hydroxyclarithromycin.
✔️ Contraindications
Hypersensitivity to esomeprazole or any formulation components.
✔️ Overdose Management
- No specific antidote. Overdose treatment is symptomatic and supportive. Dialysis is not expected to be effective due to high protein binding. Animal studies suggest toxicity signs like reduced activity, respiratory changes, tremors, and convulsions at high doses.
✔️ Pregnancy and Lactation
- Limited data on use during pregnancy; animal studies show no teratogenic effects.
- Unknown if excreted in human milk. Discontinue breastfeeding if treatment is necessary.
✔️ Precautions and Warnings
- Symptom relief does not rule out the presence of gastric malignancy.
- For patients with swallowing difficulty, capsules can be opened, and pellets mixed with a tablespoon of soft applesauce (not hot). Consume immediately without storing.
- Safe use in pediatric and geriatric populations has been established, but caution is advised in older patients due to potential sensitivity.
- For severe hepatic impairment, do not exceed 20 mg daily.
✔️ Storage
- Store in a dry place below 30°C, protected from light and moisture. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
