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Dotfix 2mg Tablet 1 Strip
Dotfix 2 is a medication used for the treatment of gout and hyperuricemia. Gout is an inflammatory condition caused by the deposition of urate crystals in the joints, often due to prolonged high levels of uric acid in the blood (hyperuricemia). Dotfix 2 works by inhibiting URAT1, a specific urate transporter, which helps reduce the reabsorption of uric acid in the kidneys and increases its excretion through urine. This lowers the overall levels of serum uric acid, which is beneficial for managing both acute gout attacks and preventing their recurrence in patients with chronic hyperuricemia.
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✅ Description:
Dotfix is used for the treatment of gout and hyperuricemia (high levels of uric acid in the blood).
Note: Always use under the guidance of a registered healthcare provider.
Dotinurad is a URAT1-selective urate reabsorption inhibitor that blocks URAT1, a transporter responsible for reabsorbing uric acid in the kidneys. By inhibiting this transporter, Dotinurad increases the excretion of uric acid in urine and helps lower serum uric acid levels. It is designed to selectively target URAT1 without affecting other transporters like ABCG2, OAT1, and OAT3, which also affect uric acid secretion. This high selectivity makes Dotinurad effective in lowering uric acid levels while minimizing the risk of disrupting uric acid secretion pathways.
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✔️ Uses of Dotfix 2:
- Treatment of gout: Helps manage and prevent gout attacks by lowering uric acid levels.
- Management of hyperuricemia: Reduces elevated uric acid levels in the blood to prevent crystal formation that causes joint inflammation.
✔️ Common side effects include:
- Gouty arthritis
- Limb discomfort (1% to less than 5% of patients)
- Loose stools
- Increased y-GTP levels
- Arthralgia (joint pain)
- Kidney stones
- Nephrocalcinosis (calcium deposits in kidneys)
- Increased urinary y2 macroglobulin
- Increased blood creatinine levels
✔️ Missed Dose:
If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. If it's near the next dose, skip the missed dose. Never take two doses at once.
✔️ Overdose:
If you accidentally take too much, consult your doctor or pharmacist immediately.
✔️ Dosage & Administration:
- Initial Dose: The usual starting dose is 0.5 mg once daily.
- Gradual Dose Increase: After 2 weeks, increase the dose to 1 mg once daily, and after 6 weeks, increase to 2 mg once daily.
- Maintenance Dose: The maintenance dose is typically 2 mg once daily, but it can be adjusted based on the patient’s condition. The maximum dose is 4 mg once daily.
✔️ Precautions Related to Dosage and Administration:
- In the early stages of treatment, rapid reduction in blood uric acid levels may trigger gouty arthritis attacks (gout flare-ups). Therefore, gradual dose escalation is recommended.
- Patients should be monitored closely when the dose is increased.
✔️ Drug Interactions:
- Pyrazinamide: This drug may weaken the effect of Dotfix because it suppresses uric acid secretion in the kidneys, potentially interfering with Dotfix's ability to increase uric acid excretion.
- Salicylic Acid (Aspirin): This can reduce the effectiveness of Dotfix by suppressing uric acid excretion.
✔️ Contraindications:
Dotfix should not be used in patients with known hypersensitivity to any of its components.
✔️ Pregnancy & Lactation:
- Pregnancy: Dotfix should be used only if the therapeutic benefits outweigh the potential risks. Consult a doctor before use during pregnancy.
- Lactation: Dotfix is excreted in breast milk. Consult your doctor before breastfeeding.
✔️ Precautions & Warnings:
- Gouty Arthritis: Rapid reduction of uric acid levels can trigger gout attacks. If a flare occurs before or during treatment, continue treatment but add medications like colchicine or NSAIDs to manage symptoms.
- Urolithiasis (Kidney Stones): Use Dotfix cautiously in patients with a history of kidney stones, as it may worsen symptoms due to increased uric acid excretion.
- Renal Impairment: Use with caution in patients with renal dysfunction. It should be avoided in patients with oliguria (low urine output) or anuria (no urine output), as it may not be effective.
- Hepatic Impairment: Use Dotfix with caution in patients with liver dysfunction. Close monitoring is necessary due to potential liver damage observed with other uricosuric agents.
✔️ Storage Conditions:
- Store below 30°C, in a dry place, away from light.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
