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✅ Description:
Indications
Febuxostat is used to treat hyperuricemia in gout patients on a long-term basis. Febuxostat is not recommended for asymptomatic hyperuricemia therapy.
Pharmacology
Febuxostat is a selective xanthine oxidase (XO) inhibitor that is non-purine. It lowers serum uric acid levels by blocking the enzyme xanthine oxidase, which produces uric acid. Xanthine oxidase converts hypoxanthine to xanthine, which is then converted to uric acid. At therapeutic concentrations, Febuxostat is unlikely to inhibit other enzymes involved in purine and pyrimidine production and metabolism.
Dosage & Administration
Febuxostat is recommended at 40 mg or 80 mg once daily. The recommended starting dose of Febuxostat is 40 mg once daily. For patients who do not achieve a serum uric acid of less than 6 mg /dL after 2 weeks with 40 mg, Febuxostat 80 mg is recommended. Febuxostat can be administered without regard to food or antacid use. No dose adjustment is necessary when administering Febuxostat to patients with mild to moderate renal or hepatic impairment.
Interaction
Concomitant administration of Febuxostat with azathioprine, mercaptopurine, or theophylline could increase plasma concentrations of these drugs resulting in severe toxicity.
Contraindications
Febuxostat is not recommended for people who are using azathioprine, mercaptopurine, or theophylline.
Side Effects
Liver function problems, nausea, arthralgia, and rash are the most prevalent side effects linked with the usage of Febuxostat.
Pregnancy & Lactation
Pregnancy Classification C. In pregnant women, there are no sufficient and well-controlled trials. Only if the possible benefit outweighs the risk to the fetus should Febuxostat be used during pregnancy. This medication is not known to be excreted in human milk. When given to a breastfeeding mother, Febuxostat should be used with caution.
Precautions & Warnings
Gout Flare: When anti-hyperuricemic drugs, such as Febuxostat, are first started, an increase in gout flares is common. Febuxostat does not need to be stopped if gout flares up during treatment. For up to six months, prophylactic therapy (i.e., nonsteroidal anti-inflammatory medicine (NSAID) or colchicine at the start of treatment) may be effective.
Storage Conditions
Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach..
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