Cytomis 200mcg Tablet 10pcs

Uses of Cytomis 200mcg Tablet

• Manage and manage peptic ulcer, predominantly caused due to excessive NSAID use (such as diclofenac, and naproxen)
• Used for cervical ripening (before certain uterine procedures)
• Used for inducing labor pain
• Can induce abortion during the first trimester of pregnancy
• Prevents excessive blood loss after childbirth

Side Effects of Cytomis 200mcg Tablet

Misoprostol is generally well-tolerated. Common side effects include gastrointestinal symptoms such as diarrhea, abdominal pain, dyspepsia, flatulence, nausea, vomiting, rashes and dizziness. To reduce diarrhea, take the medication with meals and at bedtime, and avoid antacids containing magnesium.

How does Cytomis 200mcg Tablet work?

Cytomis 200 reduces excessive stomach acid caused by prolonged NSAID use, aiding in ulcer healing, preventing new ulcers, and alleviating GI symptoms like acidity and heartburn.

It also stimulates uterine contractions to initiate labor, reduce postpartum bleeding, and induce early pregnancy abortion. Additionally, it helps soften the cervix for uterine procedures.

Before taking Cytomis 200 inform your doctor if you:

• previously delivered a baby via cesarean section
• have any problems in blood vessels
• have inflammation in the bowel (such as ulcerative colitis, Crohn’s disease)
• are more prone to dehydration easily

Indications

Misoprostol is used for medical abortion and to treat post-delivery bleeding. 

Pharmacology

Misoprostol, the active ingredient, is quickly converted to its free acid form, which is responsible for its therapeutic effects and is detectable in plasma. This free acid is extensively absorbed. Taking Misoprostol with food results in lower peak plasma concentrations, and simultaneous use with magnesium-containing antacids can reduce its overall availability. Misoprostol has mucosal protective properties and antisecretory effects that reduce gastric acid secretion. It counteracts the mucosal damage caused by NSAIDs by enhancing bicarbonate and mucus production in the stomach, although this is significant only at doses of 200 mcg or more.

Dosage of Cytomis 200mcg Tablet

Gastric and Duodenal Ulcers: For treating benign gastric and duodenal ulcers, including those caused by NSAIDs, the dosage is 800 mcg per day in divided doses (2-4 times) with meals and at bedtime. Treatment should last at least 4 weeks but can be extended up to 8 weeks if necessary.

NSAID-Induced Ulcer Prevention: Take 200 mcg with NSAIDs 2-4 times daily. If the dose is not tolerated, a lower dose of 100 mcg may be used. Follow the prescribed course throughout the NSAID therapy.

Labor Induction: Administer 25 mcg vaginally in the posterior fornix to start labor, repeating as necessary up to a total of 200 mcg every six hours. Alternatively, take 100 mcg orally. If cervical ripening or active labor is not achieved, a repeated oral dose of 100-200 mcg can be given every four hours until labor is established (Bishop score ≥7), with a maximum of six doses. Begin oxytocin four hours after the last Misoprostol dose if needed. Monitor maternal vital signs, fetal heart rate, and contractions. Report any fetal distress or excessive uterine contractions to a doctor.

Postpartum Bleeding: Immediately after delivery, take 600 mcg orally to prevent postpartum bleeding. For postpartum hemorrhage, administer 600 mcg orally or 1000 mcg rectally.

Administration

Take Cytomis 200mcg Tablet with meals to avoid stomach upset. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Interaction

Misoprostol does not show significant interactions with cardiac, pulmonary, CNS drugs, or NSAIDs. Its bioavailability decreases with high doses of antacids.

Contraindication

Misoprostol is contraindicated in individuals with a history of prostaglandin allergy and during pregnancy.

Pregnancy & Lactation

Misoprostol is contraindicated in pregnancy due to its abortifacient properties. It should not be used in women who are or may become pregnant, unless it is essential for NSAID therapy to prevent or treat NSAID-induced ulcers. If prescribed, ensure:

• A negative pregnancy test within two weeks before starting treatment.
• Adherence to effective contraceptive measures.
• Awareness of the risks associated with Misoprostol and the potential for contraception failure.

Although not extensively studied, Misoprostol's active metabolite might be excreted in breast milk. It is not recommended for use by breastfeeding mothers due to potential risks to nursing infants.

Precautions & Warnings

Misoprostol is contraindicated in pregnant women and should only be used in women of childbearing potential if necessary for NSAID-induced ulcer management. It is essential to confirm the absence of pregnancy before starting treatment and to use effective contraception.

Labor induction using Misoprostol should only be considered if the pregnancy is appropriately dated (36-38 weeks' gestation) and if no contraindications such as acute fetal distress, placental abruption, placenta previa, or unexplained vaginal bleeding are present. The fetus should be in a vertex presentation.

Storage

Store Cytomis 200 in a cool, dry place, protected from light and moisture. Keep out of reach of children.