Agoxin 0.25mg Tablet 10pcs

✔️ Uses of Agoxin 0.25mg Tablet

Manages

• Arrhythmia
• Heart failure

✔️ Side Effects of Agoxin 0.25mg Tablet

The most common side effects of taking Agoxin 0.25mg Tablet are nausea, vomiting, diarrhea, abnormal heartbeat, and dizziness. Consult your doctor if any of the side effects get worse.

✔️ How does Agoxin 0.25mg Tablet work?

It works by correcting irregular heartbeat to a normal rhythm and increases the force with which the heart muscle contracts with every heartbeat. This makes the heart pump more efficiently and increases blood circulation throughout the body.

✔️ Direction for use of Agoxin 0.25mg Tablet

Take Agoxin 0.25mg Tablet as directed by your physician. It can be taken with or without meals. Swallow the medicine as a whole with a sip of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

✔️ Quick Suggestions:

• Regular blood tests are advised while taking Digoxin-0.25 Tablet to monitor digoxin levels in the blood, potassium levels and kidney functioning.
• Low salt diet and regular exercise are recommended along with Digoxin-0.25 Tablet for effective results.
• Do the regular exercise as it helps to lower blood pressure and keeps blood vessels and heart in good condition.
• Quit smoking as smoking increases blood pressure and heart rate.
• Eat balanced and healthy diet which includes plenty of vegetables, fruits, low fat or fat free products.
• Regular electrocardiogram (ECG) should be done to see the effect of Digoxin-0.25 Tablet on your heartbeat.

✔️ Indication of Agoxin 0.25mg Tablet

Digoxin is used in the treatment of Heart failure and Arrhythmia.

✔️ Pharmacology

Digoxin is a cardiac glycoside used in the management of particularly atrial fibrillation and heart failure. The principal actions of digoxin are an increase in the force of myocardial contraction (positive inotropic activity and a reduction in the conductivity of the heart particularly in conduction through the atrioventricular node. Digoxin also has a direct action on the smooth vascular muscle and indirect effects mediated primarily by the autonomic nervous system, particularly by an increase in vagal activity.

✔️ The dosage guidelines for digoxin, administered orally, are as follows:

Oral Administration Dosage for Digoxin:

Rapid Digitalization:

• Dosage: 1-1.5 mg in divided doses over 24 hours.
• Purpose: This regimen is used when there is a need for a quick therapeutic effect, such as in acute situations.

Less Urgent Digitalization:

• Dosage: 250-500 micrograms daily (higher doses may be divided).
• Purpose: This regimen is used when a slower digitalization is appropriate, allowing the body to reach therapeutic levels of the drug gradually.

Maintenance Dose:

• Dosage: 62.5-500 micrograms daily, with higher doses possibly divided.
• Adjustments: The dose should be tailored based on renal function and the response of atrial fibrillation to heart rate control.

Usual Dosage Range:

• General Range: 125-250 micrograms daily.
• Elderly Patients: A lower dose, often within the range of 125-250 micrograms daily, may be appropriate due to reduced renal function and increased sensitivity to digoxin.

Considerations:

1. Renal Function: Dosage adjustments are crucial for patients with impaired renal function to avoid toxicity.
2. Atrial Fibrillation: The dosage should be individualized based on heart rate response in atrial fibrillation.
3. Elderly Patients: They typically require lower doses due to decreased renal clearance and increased sensitivity to the drug.

✔️ Interaction

Drug-Drug Interaction: Agoxin 0.25mg Tablet may have interaction with medicines used to treat irregular heartbeat (adenosine, amiodarone, dolasetron, quinidine), cardiac stimulants (arbutamine), HIV/AIDS drugs (atazanavir, saquinavir), anticancer drugs (ceritinib, lapatinib), antibiotics (clarithromycin), immunosuppressants (fingolimod), antidepressants (flibanserin), antifungal drugs (itraconazole) and calcium supplements (calcium chloride, calcium gluceptate, calcium gluconate).

Drug-Food Interaction: Agoxin 0.25mg Tablet may interact with alcohol. Therefore, avoid alcohol intake while taking Agoxin 0.25mg Tablet.

Drug-Disease Interaction: If you have beriberi disease caused by vitamin B1 deficiency, malabsorption syndrome (unable to absorb minerals from food), thyroid, or any lung or kidney disease, please inform your doctor before taking Agoxin 0.25mg Tablet.

✔️ Contraindications

If you are known to be allergic to Agoxin 0.25mg Tablet or any other medicines, please tell your doctor. 

✔️ Pregnancy & Lactation

Pregnancy:

• Risk: Use with caution. Although no significant risk of birth defects has been identified, underlying maternal conditions like heart failure and atrial fibrillation can pose risks to both mother and fetus. Digoxin crosses the placenta and may require dose adjustments during pregnancy and the postpartum period.

Lactation:

• Risk: Digoxin does enter breast milk, but the dose received by the infant is generally low and not clinically significant. However, monitoring is still recommended. The American Academy of Pediatrics considers digoxin "compatible with nursing."

✔️ Considerations for Use of Digoxin:

Cardiac Dysrhythmias:

• Risk: Digoxin can exacerbate certain types of arrhythmias. Close monitoring is necessary, especially in patients with preexisting dysrhythmias.

Electrolyte Imbalances:

• Hypokalaemia, Hypercalcaemia, Hypomagnesaemia: Electrolyte imbalances can increase the risk of digoxin toxicity. These conditions should be corrected before starting digoxin therapy.

Hypertension and Ischemic Heart Disease (IHD):

• Risk: Use with caution as these conditions may alter the hemodynamic response to digoxin.

Other Cardiac Conditions:

• Chronic Cor Pulmonale, Aortic Valve Disease, Acute Myocarditis, Congestive Cardiomyopathies, Constrictive Pericarditis: Patients with these conditions require careful monitoring, as digoxin may worsen symptoms or lead to complications.
• Heart Block: Digoxin can worsen heart block, particularly in patients with pre-existing conditions. It should be used with extreme caution.

Elderly Patients:

• Risk: Due to reduced renal function and increased sensitivity, lower doses are typically required to avoid toxicity.

Renal Impairment:

• Risk: Digoxin is primarily excreted by the kidneys, so dosage must be adjusted to avoid accumulation and toxicity in patients with renal impairment.

Thyroid Function Abnormalities:

• Risk: Both hyperthyroidism and hypothyroidism can affect digoxin metabolism and its effects. Monitoring and dosage adjustments are required.

✔️ Storage:

Store in a cool and dry place. Keep out of the reach of children.