Reduces risk of cardiovascular death and HF-related hospitalization in adults with symptomatic chronic heart failure, following recent hospitalization or outpatient IV diuretics.
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Capazi Tablet (Vericiguat)Stimulates soluble guanylate cyclase (sGC) → increases cGMP → improves vascular tone, cardiac function, and remodeling.
Low blood pressure, anemia.
Start with 2.5 mg once daily with food, double every 2 weeks up to 10 mg daily, as tolerated. The tablet may be crushed if needed.
Other sGC stimulators
PDE-5 inhibitors (e.g., sildenafil)
❌ Contraindicated in pregnancy.
Ensure negative pregnancy test before treatment. Use effective contraception during and for 1 month after stopping Capazi.
Store below 30°C, protected from light and moisture. Keep away from children.
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