Entrovas 50mg Tablet

✔️ Uses:

Heart failure

✔️ How does Entrovas 50mg Tablet work?

It's a combination of Sacubitril and Valsartan. Sacubitril works by inhibiting the action of certain chemical substances that cause the narrowing of the blood vessels. Thus, it eases blood flow and allows your heart to pump blood more efficiently. Valsartan works by relaxing the blood vessels that allow the blood to flow more easily. 

✔️ Side Effects of Entrovas 50mg Tablet

• Cough
• Dizziness
• Low blood pressure
• Altered potassium levels in the blood
• Decreased red blood cell count
• Hypoglycemia (low blood glucose)
• Diarrhea
• Fainting
• Headache
• Nausea
• Stomach pain
• Vertigo
• Weakness

✔️ Quick Suggestions:

• Continue to stay active and maintain a low-sodium diet.
• Rise slowly to reduce dizziness.
• Avoid potassium supplements and potassium-rich foods.
• Inform your doctor if you have kidney or liver disease.
• Not recommended during pregnancy or breastfeeding.

✔️ Indications:

Entrovas 50 is used to treat chronic heart failure, reducing the risk of hospitalization and death. It should be taken regularly as prescribed by your doctor, even if you feel well. Side effects may include cough, dizziness, and low blood pressure.

✔️ Pharmacology

It's an angiotensin receptor-neprilysin inhibitor (ARNi) that relaxes blood vessels and blocks vasoconstrictor effects.

✔️ Dosage & Administration of Entrovas 50mg Tablet

Adult Dose: Heart Failure

To reduce the risk of cardiovascular death and hospitalization for heart failure (HF) in patients with chronic heart failure (CHF) (NYHA class II-IV) and reduced ejection fraction.

Recommended starting dose: 49 mg/51 mg PO BID.

Target maintenance dose: After 2-4 weeks, double the dose to the target maintenance dose of 97 mg/103 mg PO BID as tolerated.

Hepatic Impairment

Mild (Child-Pugh A): No starting dose adjustment is required.

Moderate (Child-Pugh B): Reduce starting dose to 24 mg/26 mg BID; double the dose every 2-4 weeks to target maintenance dose of 97 mg/103 mg BID as tolerated.

Severe (Child-Pugh C): Not recommended.

Renal Dose

Renal impairment Mild-to-moderate (eGFR ≥30 mL/min/1.73 m²): No starting dose adjustment required.

Severe (eGFR <30 mL/min/1.73 m²): Reduce starting dose to 24 mg/26 mg BID; double the dose every 2-4 weeks to target maintenance dose of 97 mg/103 mg BID as tolerated.

✔️ Interaction

Drug-Drug Interactions:

Pain medication (aspirin): Use caution when taking aspirin with Entrovas 50mg Tablet, as it may interact with this medication. Consult your doctor for guidance.

Medicine used to lower cholesterol (rosuvastatin, atorvastatin): Be cautious when using these cholesterol-lowering medications alongside Entrovas 50mg Tablet. Your doctor can provide specific recommendations.

Medicine to treat both type 1 and type 2 diabetes (insulin detemir): Monitor your blood sugar levels closely when using insulin detemir with Entrovas 50mg Tablet. Adjustments to your diabetes medication may be necessary.

Blood pressure medication (metoprolol): Take metoprolol as directed by your doctor while using Entrovas 50mg Tablet. Regular blood pressure monitoring is essential.

Medication used in the management of asthma (budesonide/formoterol): Consult your healthcare provider for guidance on using budesonide/formoterol alongside Entrovas 50mg Tablet.

Drug-Food Interaction:

• Maintain a low-salt and low-fat diet while taking Entrovas 50mg Tablet. Avoid consuming foods rich in potassium, such as potassium-containing salt substitutes or over-the-counter potassium supplements. Additionally, refrain from smoking and alcohol consumption.

Drug-Disease Interactions:

Hypotension (low blood pressure): Use Entrovas 50mg Tablet with caution if you have low blood pressure.

Diabetes: Monitor your blood sugar levels closely while using this medication, especially if you have diabetes. Adjustments to your diabetes management may be necessary.

Angioedema (rapid edema or swelling beneath the skin): Be aware of the potential risk of angioedema when using Entrovas 50mg Tablet. Contact your doctor if you experience any signs of swelling.

Hyperkalemia (high potassium in the blood): Regularly monitor your potassium levels when taking Entrovas 50mg Tablet, as it may affect your potassium balance.

Renal artery stenosis: Use this medication cautiously if you have renal artery stenosis, a condition characterized by narrowed renal arteries.

Renal/liver disease: Inform your doctor about any existing renal or liver disease before starting Entrovas 50mg Tablet. Adjustments to the medication may be needed.

Renal impairment: If you have renal impairment, consult your doctor before using Entrovas 50mg Tablet. Dosing adjustments may be required.

✔️ Contraindications

• Hypersensitivity to any component
• History of angioedema related to ACE inhibitor or ARB therapy
• Concomitant use of Aliskiren in diabetic patients

✔️ Pregnancy & Lactation

• Use with caution during pregnancy.
• Use in breastfeeding mothers only if clinically needed.

✔️ Precautions & Warnings

• Entrovas 50 may increase the risk of side effects and worsen the condition.
• May not affect your ability to drive.
• Safe for use in patients with liver or kidney diseases if prescribed.
• Can cause fetal harm during pregnancy.
• Watch for signs of angioedema.
• Monitor renal function and potassium levels.
• Risk of hypotension, especially in volume-depleted patients.

✔️ Storage Conditions

Store in a cool, dry place.