Lopirel 75 | View Uses, Dosage, Interaction, Price | ePharma
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Lopirel 75mg Tablet 1 Strip

Generic: Clopidogrel

Type: Tablet

Pack Size: 10 Pcs

Lopirel contains Clopidogrel, a prodrug that undergoes metabolic activation to inhibit platelet aggregation. It achieves this by irreversibly binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP)-induced platelet activation.

  • Platelet inhibition starts within 2 hours after taking an oral dose.
  • Regular use of 75 mg daily leads to steady-state inhibition of platelet aggregation between Day 3 and Day 7 of treatment.

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✅ Description:

Pack Image of Lopirel 75 mg Tablet
Clopidogrel belongs to the anti-platelet drug class, designed to prevent blood clot formation and reduce the risk of cardiovascular events.
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✔️ Lopirel tablets are prescribed for the prevention of myocardial infarction (MI) and stroke in patients with certain cardiovascular conditions:

Acute Coronary Syndrome (ACS):

  • Used to lower the risk of myocardial infarction and stroke in individuals diagnosed with non-ST-segment elevation ACS, including unstable angina (UA) and non-ST-elevation myocardial infarction (NSTEMI).
  • Also indicated for reducing the risk of MI and stroke in patients with acute ST-elevation myocardial infarction (STEMI).

Recent MI, Recent Stroke, or Established Peripheral Arterial Disease:

  • Administered to patients with a history of recent MI, stroke, or existing peripheral arterial disease to minimize the likelihood of future cardiovascular events.

Note: This medication should be taken under the supervision of a registered physician.

✔️ Dosage & Administration

For Acute Coronary Syndrome (ACS):

  • To achieve a rapid antiplatelet effect, treatment begins with a single 300 mg oral loading dose (equivalent to 4 tablets).
  • Following this, the patient should continue with a 75 mg daily dose.
  • If no loading dose is given, the full antiplatelet effect will be delayed by a few days.

For Recent MI, Stroke, or Peripheral Arterial Disease:

  • The standard dosage is 75 mg once daily, with no loading dose required.
  • Mode of Administration:
    • Lopirel is taken orally and can be administered with or without food.
  • Pediatric Patients:
    • Safety and effectiveness have not been established.
  • Elderly Patients:
    • No dosage adjustment is required for elderly individuals.

Note: This medication should be taken under the guidance of a licensed physician.

✔️ Lopirel is generally well tolerated, but some common side effects include:
  • Bleeding complications
  • Gastrointestinal discomfort (e.g., diarrhea)
  • Skin reactions

Rare side effects:

  • Anemia, angioedema, arthralgia, arthritis
  • Bone marrow disorders, acquired hemophilia
✔️ Drug Interactions
  • Increased Bleeding Risk:
    • When taken with NSAIDs, warfarin, or serotonin/norepinephrine reuptake inhibitors (SSRIs, SNRIs), there is a higher risk of bleeding complications.
  • Metabolism Inhibition:
    • Drugs like omeprazole and esomeprazole (CYP2C19 inhibitors) can interfere with Clopidogrel’s activation, reducing its effectiveness.
  • Repaglinide Interaction:
    • Avoid co-administration, as Clopidogrel increases the plasma concentration of Repaglinide, which may lead to adverse effects.
✔️ Lopirel should not be used in patients with:
  • Hypersensitivity to Clopidogrel or any of its components.
  • Active bleeding disorders, including peptic ulcers or intracranial hemorrhage.
✔️ Pregnancy & Lactation
  • Pregnancy: No adequate studies are confirming the safety of Clopidogrel in pregnant women. It should only be used if the potential benefits outweigh the risks.
  • Lactation: It is unknown whether Clopidogrel is excreted in human breast milk. Women should discuss with their physician whether to discontinue the drug or breastfeeding.
✔️ Precautions & Warnings
  • Genetic Influence:
    • Since Clopidogrel requires metabolism via CYP2C19, genetic variations (poor metabolizers) or drug interactions with CYP2C19 inhibitors (such as omeprazole) may reduce its efficacy.
  • Bleeding Risk:
    • Since Clopidogrel inhibits platelet function for the platelet’s lifespan (7–10 days), the risk of bleeding is elevated.
    • Platelet transfusions within 4 hours of a loading dose or 2 hours of a maintenance dose may be ineffective.
  • Surgery Considerations:
    • Discontinuation of Lopirel increases cardiovascular risk, but it should be stopped 5 days before major surgery to reduce excessive bleeding risks.
    • Restart as soon as hemostasis is achieved post-surgery.
  • Thrombotic Thrombocytopenic Purpura (TTP):
    • Cases of TTP have been reported, requiring urgent plasma exchange therapy.
  • Hypersensitivity:
    • Patients who previously experienced allergic reactions (rash, angioedema, hematologic issues) to Clopidogrel or other thienopyridines should be closely monitored.
✔️ Storage Conditions
  • Store at a temperature below 30°C in a dry place, away from moisture and direct light.
  • Do not freeze.
  • Keep out of reach of children.
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