Generic Name: Rosuvastatin 10 mg
Manufacturer: Unimed Unihealth Pharmaceuticals Ltd.
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Indications
Pharmacology
HMG-CoA reductase is the rate-limiting enzyme that transforms 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase. Rosuvastatin has two mechanisms for altering lipid levels. To begin, it boosts the amount of hepatic LDL receptors on the cell surface, which improves LDL absorption and degradation. Second, Rosuvastatin decreases the total quantity of VLDL and LDL particles by inhibiting VLDL formation in the liver.
Dosage & Administration
Rosuvastatin can be taken with or without food, at any time of day.
Interaction
The significant drug interaction for rosuvastatin is
Coumarin anticoagulant: the combination extends the international normalized ratio (INR). Before starting rosuvastatin, a stable INR should be achieved. The INR should be monitored frequently until stabilized after starting or changing rosuvastatin therapy.
Concomitant lipid lowering therapy: Use with fibrates and niacin products may increase the risk of effects on skeletal muscle.
Contraindications
Side Effects
Rosuvastatin is well tolerated by most people. Headache, myalgia, constipation, asthenia, stomach pain, and nausea were the most common side effects linked to Rosuvastatin.
Pregnancy & Lactation
The safety of pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not.
Precautions & Warnings
Effects on skeletal muscle (e.g., myopathy and rhabdomyolysis): Usage of the 40 mg dose, advanced age (>65 years), hypothyroidism, renal impairment, and use of cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir, or certain other lipid-lowering medicines all enhance the risks. Patients should be encouraged to report any unexplained muscle discomfort, soreness, or weakness as soon as possible. If indications or symptoms arise, rosuvastatin can be stopped.
Abnormalities in liver enzymes and monitoring: Hepatic transaminases might be persistently elevated.
Before and during treatment, liver enzymes should be checked.
Storage Conditions
Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.
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