Generic Name: Atorvastatin Calcium 40mg
Company Name: Drug International Limited
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Indications of Divastin 40
Pharmacology of Divastin 40
Atorvastatin is a selective HMG-CoA reductase inhibitor. This enzyme is the limiting enzyme responsible for converting HMG-CoA to mevalonate, which is the precursor to sterols (including cholesterol). Atorvastatin reduces plasma levels of cholesterol and lipoproteins by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and increases the number of hepatic LDL receptors on the cell surface to enhance absorption and catabolism of LDL.
Dosage & Administration
Primary hypercholesterolemia and combined hyperlipidemia-
Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to the max. 80 mg once daily.
Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to the usual max. 20 mg once daily.
Familial hypercholesterolemia-
Adults: Initially 10 mg daily, increased at intervals of at least 4 weeks to 40 mg once daily; if necessary, further increased to max. 80 mg once daily (or 40 mg once daily combined with anion-exchange resin in heterozygous familial hypercholesterolemia).
Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to the usual max. 80 mg once daily.
Prevention of cardiovascular events-
Adults: Initially 10 mg once daily adjusted according to the response.
Interaction of Divastin 40
The risk of myopathy during Divastin 40 treatment increases with the simultaneous administration of cyclosporin, fibric acid derivatives, erythromycin, azole antifungals, and niacin. When atorvastatin was used in combination with antihypertensive drugs or hypoglycemic drugs, no clinically significant interactions were observed. If atorvastatin is added to digoxin, erythromycin, oral contraceptives, colestipol, antacids, and warfarin, the patient should be closely monitored.
Contraindications
Divastin 40 should not be given to patients who are allergic to any component of this drug. Divastin 40 is contraindicated for active liver disease or unexplained elevated serum transaminases. It is also contraindicated for patients with a history of serious adverse reactions to previous use of HMG-CoA reductase inhibitors.
Side Effects of Divastin 40
Divastin 40 is generally well tolerated. The most common side effects of Divastin 40 are constipation, flatulence, indigestion, and abdominal pain. Other side effects include infection, headache, back pain, skin rash, weakness, joint pain, and myalgia.
Pregnancy & Lactation
Pregnancy: Divastin 40 is contraindicated during pregnancy. The safety of pregnant women has not been determined. No controlled clinical trials of atorvastatin have been conducted in pregnant women. Rare reports of birth defects have been received after intrauterine exposure to HMG-CoA reductase inhibitors. Animal studies have shown that it is toxic to reproduction. Treatment of mothers with atorvastatin may reduce the fetus's mevalonate levels, which is a precursor of cholesterol biosynthesis. Divastin 40 should not be used in women who are pregnant, trying to become pregnant, or are suspected of becoming pregnant. Atorvastatin treatment should be stopped during pregnancy or before it is determined that the woman is not pregnant.
Lactation period: It is unknown whether Divastin 40 or its metabolites are excreted from human milk. In rats, the plasma concentrations of Divastin 40 and its active metabolite are similar to those in milk. Due to the possibility of serious adverse reactions, women taking atorvastatin should not breastfeed their babies. Divastin 40 is contraindicated during lactation.
Precautions & Warnings
Liver effects: Liver function tests should be performed before starting treatment and regularly after treatment. Patients who drink a lot of alcohol or have a history of liver disease should use atorvastatin with caution. If there is a significantly elevated CPK level or myopathy is diagnosed or suspected, Divastin 40 treatment should be discontinued.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
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