Dupalaki 100mg Tablet 10pcs

Uses of Dupalaki 100

• Severe hypertriglyceridemia
• Hypercholesterolemia

How does Dupalaki 100 work?

Dupalaki 100 works by increasing the natural lipid (fat) breakdown process with the help of an enzyme. This removes the bad cholesterol and triglycerides from your blood and increases the levels of good cholesterol.

Side Effects of Dupalaki 100

Common side effects include headache, dizziness, somnolence, vertigo, nausea, vomiting, diarrhea, dyspepsia, abdominal pain, rash, alopecia, myalgia, and fatigue.

Quick Suggestions:

• Take Dupalaki 100 with or without food as instructed by your doctor.
• Do not break, crush, or chew the tablet/capsule.
• It may take 2 months to get maximum benefits from this medicine. Make sure to check the expiry date before taking Dupalaki 100.
• Keep this medicine away from children and pets.
• Take a low-salt and low-fat diet and exercise regularly for better results.
• Take Dupalaki 100 at the same time every day as it will help you to remember.
• Your doctor may suggest periodic blood tests to check your lipid (fat) levels and other blood components while taking this medicine.

Indication of Dupalaki 100

Ciprofibrate is used as an adjunct to diet, exercise, and weight reduction for managing certain lipid disorders. Its indications include:

• Severe hypertriglyceridemia with or without low HDL cholesterol.
• Mixed hyperlipidemia, especially when statins are contraindicated or not tolerated.

Pharmacology

Ciprofibrate works by lowering levels of LDL (low-density lipoprotein) and VLDL (very low-density lipoprotein), which in turn reduces triglycerides and cholesterol levels associated with these lipoproteins. It also increases HDL (high-density lipoprotein) cholesterol levels. Ciprofibrate is effective in treating hyperlipidemia, reducing the risk of coronary heart disease events.

Dosage & Administration of Dupalaki 100

• Adults: The usual dose is 100 mg daily. This should not be exceeded.
• Renal impairment: For moderate renal impairment (creatinine clearance 30-80 ml/min/1.73 m²), reduce the dose to one tablet every other day. Ciprofibrate should be avoided in severe renal impairment (creatinine clearance <30 ml/min/1.73 m²).
• Hepatic impairment: Use with caution, and discontinue if AST/ALT levels exceed three times the upper limit of normal or if cholestatic liver injury occurs.
• Elderly: The same dosage as adults, but extra precautions should be taken for individuals over 70 years old.
• Children: Not recommended due to lack of safety and efficacy data.

Interaction

• Other fibrates & statins: Combining Ciprofibrate with fibrates or HMG CoA reductase inhibitors (statins) can increase the risk of myopathy, rhabdomyolysis, and myoglobinuria.
• Oral anticoagulants: Ciprofibrate may enhance the effects of oral anticoagulants. Dose adjustment and monitoring (INR) are required.

Contraindications

• Hypersensitivity to Ciprofibrate or its excipients.
• Severe hepatic or renal impairment (creatinine clearance <30 ml/min/1.73 m²).
• Pregnancy and lactation.
• Concurrent use with another fibrate.

Pregnancy & Lactation

• No human data is available, but animal studies showed signs of toxicity at high doses, so Ciprofibrate is contraindicated in pregnancy.
• Ciprofibrate is also contraindicated in nursing mothers due to a lack of safety data.

Precautions & Warnings

• Myalgia/Myopathy: Patients should report unexplained muscle pain, tenderness, or weakness immediately.
• Hepatic function: Periodic liver function tests are recommended, especially during the first 12 months of treatment.
• Lactose intolerance: Patients with galactose intolerance, lactase deficiency, or glucose-galactose malabsorption should avoid this medication.

Storage:

Store below 30°C, protect from light and moisture and keep out of reach of children.