Rocovas 10mg Tablet 10pcs

✔️ Uses of Rocovas 10mg Tablet

• Manage high blood cholesterol levels
• Prevents the risk of heart attack or stroke

✔️ How does Rocovas 10mg Tablet work?

Rosuvastatin is a lipid-lowering medication (statin). It works by blocking an enzyme (HMG-CoA-reductase) that is required by the body to make cholesterol, thereby lowering "bad" cholesterol (LDL) and triglycerides and raising "good" cholesterol (HDL).

✔️ Common adverse events include

• Headache
• Myalgia
• Constipation
• Asthenia
• Abdominal pain
• Nausea

✔️ Quick Suggestions:

• Maintain a healthy diet and exercise routine as advised by your doctor.
• Regularly monitor any changes in your health and report them to your doctor.
• Always consult your doctor before making any changes to your medication regimen.
• Do not take Rosuvastatin if you are pregnant, planning a pregnancy, or breastfeeding.

✔️ Indications:

Rosuvastatin is prescribed to treat high cholesterol by lowering "bad" cholesterol (LDL) and triglycerides (fats). It should be used in conjunction with regular exercise and a low-fat diet.

✔️ Pharmacology

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the enzyme responsible for converting 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. It works by:

1. Increasing hepatic LDL receptors on cell surfaces enhances the uptake and breakdown of LDL.
2. Inhibiting hepatic synthesis of VLDL, thus reducing the total number of VLDL and LDL particles.

✔️ Dosage & Administration of Rocovas 10mg Tablet

• General Dose Range: 5-40 mg once daily. The 40 mg dose is reserved for patients not reaching LDL-C goals with 20 mg.
• Homozygous Familial Hypercholesterolemia (HoFH): Starting dose of 20 mg/day.
• Pediatric Patients with Heterozygous Familial Hypercholesterolemia (HeFH):
  • Ages 8 to <10 years: 5-10 mg/day.
  • Ages 10 to 17 years: 5-20 mg/day.
• Pediatric Patients with HoFH (Ages 7 to 17 years): 20 mg/day.
• Note: Always take medication as advised by your doctor.

Administration:

• Rosuvastatin can be taken with or without food, at any time of day.
• Note: Always follow your doctor's advice on medication intake.

✔️ Interaction

• Cyclosporine: Increases Rosuvastatin exposure; limit Rosuvastatin to 5 mg once daily.
• Gemfibrozil: Avoid combination; if used together, limit Rosuvastatin to 10 mg once daily.
• Lopinavir/Ritonavir or Atazanavir/Ritonavir: Increases Rosuvastatin exposure; limit Rosuvastatin to 10 mg once daily.
• Coumarin Anticoagulants: Prolongs INR; ensure stable INR before starting Rosuvastatin, monitor INR frequently until stable.
• Concomitant Lipid-Lowering Therapies: Using fibrates and niacin increases the risk of skeletal muscle effects.

✔️ Contraindications

• Known hypersensitivity to product components.
• Liver disease, including unexplained persistent elevations in hepatic transaminase levels.
• Pregnant women and women who may become pregnant.
• Nursing mothers.

✔️ Pregnancy & Lactation

• Safety in pregnant women has not been established.
• Unknown if excreted in human milk.

✔️ Precautions & Warnings

• Skeletal Muscle Effects: Risks increase with 40 mg dose, advanced age (>65 years), hypothyroidism, renal impairment, and combination with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir, or other lipid-lowering drugs. Report unexplained muscle pain, tenderness, or weakness promptly. Discontinue Rosuvastatin if symptoms appear.
• Liver Enzyme Abnormalities: Monitor liver enzymes before and during treatment.
• Children: Safety and effectiveness not established.

✔️ Storage Conditions:

• Store below 30°C, protected from light and moisture.
• Keep out of reach of children.