Rolip 20mg Tablet 10pcs

Uses of Rolip 20mg Tablet

• Hyperlipidemia
• Hypertriglyceridemia
• Type 3 Hyperlipoproteinemia

Side Effects of Rolip 20mg Tablet

Rolip is generally well tolerated. The most frequent adverse events related to Rolip include:

• Headache
• Myalgia
• Constipation
• Asthenia
• Abdominal pain
• Nausea

How does Rolip 20mg Tablet work?

Rolip 20 works by interfering with the process of cholesterol synthesis. Cholesterol is made by an enzyme HMG-CoA reductase, rosuvastatin inhibits this enzyme, thus lowering cholesterol levels. It also increases good cholesterol known as high-density lipoprotein (HDL) levels.

Quick Suggestions:

• In general, Rolip 20mg Tablet is safe. It may cause diarrhea, gas, or an upset stomach. If any of these happen to you, take it with food.
• Inform your doctor if you experience fatigue, muscle weakness, or muscle pain.
• Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform your doctor if you notice signs of liver problems such as stomach pains, unusually dark urine, or yellowing of skin or eyes.
• Inform your doctor if you have kidney disease, liver disease, or diabetes before starting treatment with this medicine. If you are diabetic, monitor your blood sugar level regularly as Rosuvas 40 Tablet may cause an increase in your blood sugar level.
• Do not take Rosuvas 40 Tablet if you are pregnant, planning a pregnancy, or breastfeeding.

Indication

Rolip is indicated for:

• Heterozygous Hypercholesterolemia (Familial and Non-familial)
• Homozygous Hypercholesterolemia (Familial)
• Mixed Dyslipidemia (Fredrickson Type IIa and IIb)
• Primary prevention of cardiovascular disease

Pharmacology

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin works by:

1. Increasing the number of hepatic LDL receptors on the cell surface enhances the uptake and catabolism of LDL.
2. Inhibiting hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.

Dosage & Administration

• General Dose Range: 5-40 mg once daily. Use the 40 mg dose only for patients not reaching the LDL-C goal with 20 mg.
• HoFH (Homozygous Familial Hypercholesterolemia): Starting dose 20 mg/day.
• Pediatric Patients with HeFH (Heterozygous Familial Hypercholesterolemia):
  • 5-10 mg/day for patients 8 to less than 10 years of age.
  • 5-20 mg/day for patients 10 to 17 years of age.
• Pediatric Patients with HoFH: 20 mg/day for patients 7 to 17 years of age.
• Take as per doctor's advice.

Rosuvastatin can be taken with or without food, at any time of day.

Interaction

Significant drug interactions of Rolip include:

• Cyclosporine: Increases Rolip exposure. Limit the Rolip dose to 5 mg once daily.
• Gemfibrozil: Combination should be avoided. If used together, limit the Rolip dose to 10 mg once daily.
• Lopinavir/Ritonavir or Atazanavir/Ritonavir: Increases Rolip exposure. Limit the Rolip dose to 10 mg once daily.
• Coumarin Anticoagulants: Prolongs international normalized ratio (INR). Achieve stable INR before starting Rolip and monitor frequently until stable.
• Concomitant Lipid-lowering Therapies: Use with fibrates and niacin products may increase the risk of skeletal muscle effects.

Contraindications

Rosuvastatin is contraindicated in patients with:

• Known hypersensitivity to product components.
• Liver disease, including unexplained persistent elevations in hepatic transaminase levels.
• Pregnancy and women who may become pregnant.
• Nursing mothers.

Pregnancy & Lactation

• Safety in pregnant women has not been established.
• It is not known whether Rosuvastatin is excreted in human milk.

Precaution & Warnings:

• Skeletal Muscle Effects (e.g., myopathy and rhabdomyolysis): Risks increase with the use of 40 mg dose, advanced age (>65 years), hypothyroidism, renal impairment, and combination use with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir, or certain other lipid-lowering drugs. Patients should report unexplained muscle pain, tenderness, or weakness. Discontinue Rolip if signs or symptoms appear.
• Liver Enzyme Abnormalities and Monitoring: Persistent elevations in hepatic transaminases can occur. Monitor liver enzymes before and during treatment.

Storage Conditions:

• Keep below 30°C, protected from light and moisture.
• Keep out of reach of children.