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Tiginor EZ 20mg/10mg Tablet 1 Strip
Tiginor EZ Tablet
- Atorvastatin: Lowers cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver. It also increases LDL receptor activity, which enhances LDL catabolism.
- Ezetimibe: Inhibits cholesterol absorption in the small intestine, reducing cholesterol delivery to the liver. This increases the clearance of cholesterol from the blood.
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✅ Description:
Tiginor EZ Tablet
- Primary Hyperlipidemia: Tiginor EZ is used to reduce elevated levels of total cholesterol (total-C), LDL-C (low-density lipoprotein cholesterol), Apo B (apolipoprotein B), triglycerides (TG), non-HDL-C, and increase HDL-C (high-density lipoprotein cholesterol) in patients with primary hyperlipidemia (both familial and non-familial) or mixed hyperlipidemia.
- Homozygous Familial Hypercholesterolemia (HoFH): It is used to reduce elevated total-C and LDL-C levels in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or when such treatments are unavailable.
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✔️ Side Effects
Rhabdomyolysis, myopathy, liver enzyme abnormalities, myalgia, abdominal pain, increased hepatic enzymes.
✔️ Dosage & Administration:
- Starting Dosage: 10/10 mg or 20/10 mg daily, which can be taken as a single dose at any time of the day, with or without food.
- For patients needing a larger LDL-C reduction (>55%), the starting dose is 40/10 mg daily.
- Homozygous Familial Hypercholesterolemia: The recommended dosage is 40/10 mg or 80/10 mg daily.
- Lipid levels should be checked 2 or more weeks after initiation or dose adjustments, and dosage should be adjusted as needed.
- Pediatric Use: Not established in pediatric patients.
- Geriatric Use: No dosage adjustment needed for elderly patients.
✔️ Interactions:
- Increased risk of myopathy when combined with fibric acid derivatives, niacin, cyclosporine, or strong CYP3A4 inhibitors (e.g., clarithromycin, HIV protease inhibitors, itraconazole).
- Gemfibrozil: Avoid concurrent use due to an increased risk of rhabdomyolysis.
- Warfarin: INR should be monitored if used with warfarin.
- Colchicine: Caution should be exercised when coadministering with colchicine.
✔️ Contraindications:
- Active liver disease or persistent unexplained elevations in hepatic transaminase levels.
- Hypersensitivity to any components of the preparation
✔️ Pregnancy & Lactation:
- Pregnancy Category X: Tiginor EZ is contraindicated in pregnant women or those who may become pregnant. It is not recommended during pregnancy because lipid-lowering drugs do not benefit the fetus and can interfere with fetal development.
- It is unknown if atorvastatin is excreted in human milk, but similar drugs may pass into breast milk.
✔️ Precautions & Warnings:
- Myopathy: Be cautious with colchicine coadministration due to an increased risk of rhabdomyolysis.
- Liver Enzymes: Liver function tests should be conducted before starting treatment and monitored as needed. Discontinue if liver injury occurs.
- Endocrine Function: Caution is advised when combined with drugs that may affect steroid hormone levels.
✔️ Storage Conditions:
- Store below 30°C, in a dry place, away from light, and out of reach of children.
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