Bromodel 2.5mg Tablet 10pcs

Uses of Bromodel 2.5mg Tablet

• Parkinson's disease
• High prolactin disorder
• Acromegaly
• Type 2 diabetes

How does Bromodel 2.5mg Tablet work?

Bromodel 2.5 corrects hormonal imbalance and brain disorders. It contains a medicine called bromocriptine which is a dopamine agonist and a prolactin inhibitor. It reduces the excess production of a hormone called prolactin in the body that causes galactorrhoea (increased breast milk production), infertility problems, or certain non-cancerous tumors (such as prolactinoma). It treats acromegaly by reducing the growth hormone produced in the body. It also reduces the signs and symptoms of parkinsonism (rigidity, tremor, and muscle stiffness) by replacing the lost dopamine levels in the brain.

Side Effects of Bromodel 2.5mg Tablet

• Headache
• Dizziness
• Drowsiness
• Fatigue
• Nausea (feeling sick)
• Vomiting (being sick)
• Constipation
• Stomach upset
• Blocked nose

Quick Suggestions:

• Monitor your blood sugar level as it is known to lower blood prolactin levels.
• Quit smoking as smoking increases the heart rate and may progress to a heart ailment.
• Eat a healthy balanced diet, including plenty of fluids, vegetables, proteins, and fat-free or low-fat dairy products. It will also help to reduce weight and lowers the risk of a heart attack.
• Regular exercise keeps the mind thoughtful and lowers your stress level, thus lowering the prolactin level.
• Monitor your blood pressure, kidney, and liver function test regularly.
• You should have a test of glycated hemoglobin (HbA1C) every 3 months to check your blood glucose level control.

Indication of Bromodel 2.5mg Tablet

Bromocriptine belongs to the group of medicines called Dopamine agonists. It helps to treat hormonal disorders associated with increased levels of a hormone called prolactin in the body. It is used to stop breast milk production among lactating women who wish to stop breastfeeding. It can also be used to treat infertility problems (such as delay in puberty or lack of periods in both men and women) and prolactinomas (non-cancerous tumors of the brain) which are caused due to increased levels of prolactin in the blood.

Pharmacology

Bromocriptine is a dopamine receptor agonist that primarily inhibits the secretion of prolactin by activating post-synaptic dopamine receptors. In acromegaly, it lowers elevated blood levels of growth hormone. It significantly reduces plasma levels of prolactin in patients with both physiologically elevated prolactin and hyperprolactinemia.

Dosage & Administration of Bromodel 2.5mg Tablet

Adult Dosage:

Parkinson's Disease (as an adjunct to levodopa):

• 1st week: 1-1.25 mg at night
• 2nd week: 2-2.5 mg at night
• 3rd week: 2.5 mg twice daily
• 4th week: 2.5 mg three times daily, then increase as needed.
• Maintenance: 10-40 mg/day

Hyperprolactinemia:

• Initial: 1.25-2.5 mg daily
• May increase by 2.5 mg/day every 2-7 days
• Usual therapeutic dosage: 5-7.5 mg/day, ranges from 2.5-15 mg/day
• Up to 30 mg/day has been used in some patients with amenorrhea and/or galactorrhea

Acromegaly (Parlodel):

• Initial: 1.25-2.5 mg at bedtime for 3 days
• May increase by 1.25-2.5 mg/day every 3-7 days
• Not to exceed 100 mg/day
• Adjunct to surgery and radiotherapy: Initial 2.5 mg twice daily, increase slowly up to 5 mg every 6 hours if needed

Lactation Suppression:

• 2.5 mg/day for 2-3 days, then up to 2.5 mg twice daily for 14 days

Prevention of Puerperal Lactation:

• 2.5 mg on the day of delivery, then 2.5 mg twice daily for 14 days

Cyclical Benign Breast and Menstrual Disorders:

• 2.5 mg twice daily

Hepatic Impairment:

• Dose adjustment may be necessary; there are no specific guidelines

Child Dosage:

• Hyperprolactinemia (Ages 11-15 years):
  • Initial: 1.25-2.5 mg daily
  • Maintenance: 2.5-10 mg/day as advised by your physician

Administration Instructions:

• Swallow the medicine with a glass of water.
• Do not crush or chew the medicine.
• Take Bromocriptine preferably with meals.
• Your doctor will decide the correct dose and duration of therapy depending on your age, body weight, and disease condition.

Interaction

• Erythromycin: Increases the bioavailability of Bromocriptine.
• Alcohol: Reduces tolerance to Bromocriptine and vice versa.
• Antihypertensives: Effects may be potentiated when used concurrently with Bromocriptine.
• Psychotropics: Concurrent use should be avoided as interactions may occur.

Contraindications

• Breast carcinoma
• Hypersensitivity to ergot alkaloids
• Uncontrolled hypertension
• Severe ischaemic heart disease
• Pregnancy and lactation.

Pregnancy & Lactation

Pregnancy 

• The safety of Bromocriptine treatment during pregnancy for both the mother and fetus has not been fully established.
• If pregnancy occurs during Bromocriptine administration, careful observation of these patients is mandatory.
• Prolactin-secreting adenomas may expand, causing compression of the optic or other cranial nerves, which may necessitate emergency pituitary surgery; in most cases, this compression resolves after delivery.
• Reinitiation of Bromocriptine treatment has been reported to improve visual fields in patients who experienced nerve compression during pregnancy.
• For patients being treated for hyperprolactinemia, Bromocriptine should be withdrawn when pregnancy is diagnosed.
• In patients with acromegaly, prolactinoma, or Parkinson's disease who become pregnant, it should be determined whether continuing therapy is medically necessary or if it can be discontinued.
• If therapy is continued, it should be discontinued in those who may experience hypertensive disorders of pregnancy (e.g., eclampsia, preeclampsia, or pregnancy-induced hypertension) unless Bromocriptine withdrawal is considered medically contraindicated.

Lactation:

• Avoid use during lactation in postpartum women.

Precautions & Warnings

• Bromocriptine increases the likelihood of conception.
• Use with caution in patients with a history of peptic ulcer.
• Monitor patients with diabetes closely, especially those with diabetic retinopathy.
• Exercise caution in patients with liver or kidney impairment.
• Be vigilant for any respiratory-related issues.
• Use cautiously in patients with a history of psychosis.
• Patients with cardiovascular conditions should use Bromocriptine under strict medical supervision.
• Exercise caution when prescribing to patients with dementia.
• Use with caution in patients taking antihypertensive medications.
• Bromocriptine may impair the ability to drive or operate machinery. Patients should be advised accordingly.
• Should not be used during lactation in postpartum women.

Storage Conditions:

Store in a cool and dry place away from sunlight