Endofree 2.5 | 5pcs | Letrozole | Discount Price | ePharma
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Home Medicines Hormonal Therapy Endofree 2.5mg Tablet 5pcs
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Endofree 2.5mg Tablet 5pcs

Generic: Letrozole

Type: Tablet

Pack Size: 5 Pcs

  • Letrozole is used to treat early breast cancer in postmenopausal women, alone or with other treatments like surgery or radiation. It can also treat advanced breast cancer and infertility.
  • It belongs to a class of drugs called aromatase inhibitors, reducing estrogen levels in the body. Please take it as prescribed by your doctor.

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Discount Price: ৳ 186
MRP: ৳ 200 7% Off

⪼ Save  ৳: 14  in this Product


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✅ Description:

Endofree 2.5mg Tablet is an anti-cancer medicine classified as an aromatase inhibitor, primarily used in postmenopausal women to treat breast cancer. Breast cancer cells often depend on estrogen for growth, and Endofree 2.5mg Tablet blocks the aromatase enzyme involved in estrogen production, thus inhibiting cancer cell growth and spread.

It's important to adhere to your doctor's prescribed duration for Endofree 2.5mg Tablet usage. Common side effects may include increased cholesterol levels, fatigue, weakness, sweating, joint pain, and hot flashes. If you experience any persistent side effects, don't hesitate to discuss them with your doctor.

Before taking Endofree 2.5mg Tablet, inform your doctor about any kidney or liver issues, as well as any history of bone problems like osteoporosis or joint pain. This medication is only suitable for postmenopausal women and should be avoided during pregnancy or breastfeeding due to potential harm to the baby.

Endofree 2.5mg Tablet may cause drowsiness and dizziness, so avoid driving if you experience these symptoms. It's not recommended for use in children due to a lack of safety data. Additionally, alcohol consumption with Endofree 2.5mg Tablet may exacerbate drowsiness and dizziness, so it's best to avoid alcohol while taking this medication. Always keep your doctor informed about your health status and any other medications you may be taking to prevent potential interactions or adverse effects.

Safety Advices


Alcohol
UNSAFE

Consuming alcohol with Endofree does not cause any harmful side effects.


Pregnancy
UNSAFE

Endofree is highly unsafe to use during pregnancy. Consult your doctor as studies have shown significant harmful effects on the developing baby.


Breastfeeding
UNSAFE

Endofree is unsafe to use during breastfeeding. It may cause toxicity to the baby.


Driving
CONSULT YOUR DOCTOR

Endofree may decrease alertness, affect vision, or induce sleepiness and dizziness. Avoid driving if experiencing these symptoms.


Kidney
CONSULT YOUR DOCTOR

Use Endofree with caution in patients with liver disease. Dose adjustment may be needed. Consult your doctor.


Liver
CONSULT YOUR DOCTOR

Endofree is safe to use in patients with kidney disease. No dose adjustment is recommended, but limited information is available for end-stage kidney disease. Consult your doctor.

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✔️ Uses of Endofree 2.5mg Tablet
  • Breast cancer
  • Infertility due to anovulation
✔️ How does Endofree 2.5mg Tablet work?

Letrozole in Endofree Tablet works by reducing the level of a natural female hormone known as oestrogen that is produced in the body. Eventually, stopping the growth of the cancer cells, which depend on oestrogen for its growth.

✔️ Side Effects of Endofree 2.5mg Tablet
  • Common: Hot flushes, hypercholesterolemia, fatigue, increased sweating, arthralgia, skin rash, headache, dizziness, gastrointestinal disorders, bone pain, edema, depression, weight gain, hypertension, abdominal pain, dry skin, vaginal bleeding, palpitations, joint stiffness, chest pain.
  • Rare: Nervous disorders, somnolence, carpal tunnel syndrome, eye disorders, itching, vaginal discharge, weight loss, urinary tract infection, cough, increased enzymes, jaundice.
✔️ Quick Suggestions:
  • You have been prescribed Letrozole for the treatment of breast cancer.
  • It can be taken with or without food.
  • Do not drive or do anything requiring concentration until you know how Letrozole affects you.
  • It may cause increased sweating and hot flashes. Try to keep cool by wearing light and airy clothes.
  • Your doctor may monitor your cholesterol level and bone mineral density (BMD) regularly as Letrozole can alter their levels.
✔️ Breast Cancer

Breast cancer is characterized by the abnormal growth of cells in the breast tissue, often influenced by estrogen. These cancerous cells can originate in different parts of the breast, including the lobules, ducts, fatty tissue, or fibrous connective tissue. As the cancer progresses, it can invade surrounding healthy breast cells and may spread to nearby lymph nodes, serving as a pathway for further metastasis to other parts of the body.

Common symptoms of breast cancer include the presence of a lump or thickening in the breast tissue, which feels distinct from the surrounding area. Other signs may include breast pain, redness, swelling, abnormal nipple discharge (such as bloody discharge), changes in the shape, size, or appearance of the breast, skin changes like peeling or scaling, and the presence of a lump or swelling under the arm.

Early detection through regular breast self-exams, clinical breast exams, and mammograms can significantly improve outcomes, as breast cancer is most treatable when diagnosed in its early stages. Prompt medical attention should be sought if any concerning symptoms are noticed, as early intervention can lead to more effective treatment and a better prognosis.

✔️ Induction of Ovulation (Female Infertility)

Induction of ovulation is a treatment approach used to help women who experience infertility due to issues with ovulation. Ovulation induction involves the use of medications to stimulate the ovaries to release eggs (ovulation) in a controlled manner, increasing the chances of conception.

This treatment is typically recommended for women who have irregular or absent ovulation, which can be caused by various factors such as polycystic ovary syndrome (PCOS), hypothalamic dysfunction, or other hormonal imbalances.

Common medications used for ovulation induction include:

  • Clomiphene citrate: This medication is taken orally and works by blocking estrogen receptors in the brain, leading to increased production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which stimulate the ovaries to release eggs.
  • Gonadotropins: These are injectable hormones that directly stimulate the ovaries to produce multiple follicles, each containing an egg. Gonadotropins contain either FSH alone or a combination of FSH and LH.
  • Letrozole: Although primarily used to treat breast cancer, letrozole is also sometimes used off-label for ovulation induction. It works similarly to clomiphene citrate by stimulating the production of FSH and LH.

Ovulation induction is usually accompanied by careful monitoring through hormonal assays and ultrasound scans to track follicle development and determine the optimal timing for intercourse or assisted reproductive techniques such as intrauterine insemination (IUI) or in vitro fertilization (IVF).

It's essential for women undergoing ovulation induction to be monitored closely by a fertility specialist to minimize the risk of complications such as multiple pregnancies and ovarian hyperstimulation syndrome (OHSS). Additionally, lifestyle modifications such as maintaining a healthy weight, managing stress, and avoiding smoking can enhance the effectiveness of ovulation induction treatments.

✔️ Indications:
  • Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer.
  • First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer.
  • Treatment of advanced breast cancer in postmenopausal women who have previously been treated with antioestrogens.
  • Pre-operative therapy in postmenopausal women with localized hormone receptor-positive breast cancer.
✔️ Pharmacology

 Letrozole inhibits estrogen biosynthesis by binding to the aromatase enzyme, reducing estrogen production in tissues. It suppresses plasma estrogen concentrations in postmenopausal patients with advanced breast cancer.

✔️ Dosage:

Recommended dose: 2.5 mg once daily for 5 years in adjuvant and extended adjuvant therapy. In metastatic disease, continue until tumor progression. No dose adjustment is needed for hepatic or renal impairment.

✔️ Administration:
  • Endofree Tablet should be taken as directed by your doctor.
  • Swallow it whole with a glass of water. Do not cut, break or chew the medicine.
  • It can be taken with or without food.
  • It would be best if you took it at a fixed time for optimal results.
  • You should not consume it more than that prescribed by your doctor.
✔️ Interaction

No clinically significant interactions with cimetidine or warfarin were observed.

✔️ Contraindications

Hypersensitivity to letrozole, aromatase inhibitors, or ingredients. Contraindicated during pregnancy, lactation, and in severe hepatic dysfunction.

✔️ Pregnancy & Lactation

Not recommended during pregnancy or lactation.

✔️ Precautions & Warnings

Exercise caution in moderate hepatic dysfunction. No dose adjustment is needed for renal impairment. Patients should be aware of potential fatigue and dizziness, affecting driving or machinery operations.

✔️ Storage Conditions:

Store below 30°C, away from light and moisture. Keep out of reach of children.

Frequently Asked Questions (FAQ)

Take it as soon as possible. If close to the next dose, skip the missed one. Do not double the dose.

A: Yes, hot flashes and increased sweating are common side effects of Letrozole due to decreased estrogen levels. These symptoms may reduce over time or with treatment.

A: Yes, Letrozole may cause tiredness by reducing red blood cell levels. Inform your doctor if you experience fatigue, especially if you have other health conditions.

A: Letrozole may lower white blood cell count, weakening the immune system and increasing infection risk. Monitor for signs of infection and inform your doctor if you experience fever.

A: Serious side effects of Letrozole are rare but may include stroke, heart attack, blood clots, osteoporosis, and severe skin reactions. Seek medical attention if you experience any of these.

A: Take Letrozole as prescribed by your doctor, with a glass of water, and do not crush or chew the tablets.

A: Letrozole is restricted for use in inducing ovulation in infertility, as per guidelines. Consult your doctor for appropriate treatment options.

A: Yes, you can take Letrozole with irbesartan. However, monitor your blood pressure regularly, as Letrozole may increase it.

A: The duration of Letrozole treatment depends on the stage of breast cancer and your individual circumstances. It may be prescribed for a specific period, such as 5 years, or until the tumor progresses.

A: Letrozole is an anti-estrogen drug that reduces estrogen production in the body by blocking the aromatase enzyme. Estrogen stimulates the growth of certain types of breast cancer, and by reducing estrogen levels, Letrozole helps prevent cancer growth.

A: Letrozole is prescribed to treat breast cancer in women who have reached menopause or have stopped having periods, either naturally or due to surgery or chemotherapy.

A: Letrozole may lead to bone thinning or osteoporosis due to decreased estrogen levels. Your doctor may monitor your bone density during treatment.
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Check our pricing section for Endofree 2.5mg Tablet 5pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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