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- Oestrogel is a female sex hormone (estrogen) used in hormone replacement therapy (HRT).
- It treats menopausal symptoms, prevents osteoporosis, and is used in certain cancers.
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✅ Description:
- Oestrogel contains 17-B-Estradiol, and its chemical structure is identical to the most active form of ovarian hormone.
- 17-B-Estradiol is a natural form of estrogen found in the human body.
- Physiological estradiol in Oestrogel is derived from a plant source. This is likely a form of bioidentical estrogen, meaning it is structurally identical to the estrogen produced in the human body.
- Oestrogel is presented in a tube containing a transparent, colorless, and fragrance-free gel.
- Being a percutaneous gel, it allows for absorption through the skin, avoiding first-pass metabolism by the liver.
- Percutaneous gels are a preferred route for patients who cannot take oral medications. This could include individuals with contraindications, gastrointestinal issues, or those experiencing adverse effects from oral forms.
- The presentation of Oestrogel is in a tube containing 80g of gel, with each containing 60mg of 17-B-Estradiol.
- Oestrogel has received approval from the U.S. Food and Drug Administration (FDA), indicating that it has undergone regulatory scrutiny and meets the necessary safety and efficacy standards.
- Oestrogel, containing bioidentical estradiol, is likely prescribed as part of hormone replacement therapy (HRT) to address estrogen deficiency in conditions such as menopause.
Safety Advices
Alcohol
CAUTION
It is recommended to consult your doctor regarding alcohol use.
Pregnancy
CONSULT YOUR DOCTOR
- Consult your doctor before using Oestrogel during pregnancy.
- Limited human studies are available, and animal studies suggest potential harm to the developing baby.
- Your doctor will assess the benefits and risks before prescribing this medication during pregnancy.
Breastfeeding
CONSULT YOUR DOCTOR
- Oestrogel is considered unsafe during breastfeeding.
- Data indicates potential toxicity to the baby through breast milk.
- Avoid its use while breastfeeding; consult your doctor for alternative options.
Driving
SAFE
- Oestrogel is not known to significantly affect your ability to drive.
- It is generally considered safe for driving.
Kidney
CAUTION
- Use Oestrogel with caution in patients with kidney disease.
- Dose adjustment may be necessary.
- Consult your doctor for personalized advice.
Liver
CAUTION
- Exercise caution when using Oestrogel in patients with liver disease.
- A dose adjustment might be required.
- Avoid using Oestrogel in patients who previously had liver disease and the liver function tests are still not normal.
- Consult your doctor for guidance on its use in liver conditions.
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✔️ Uses of Oestrogel
Hormonal replacement therapy (HRT) for estrogen deficiency
✔️ How does Oestrogel work?
- Estradiol is a naturally occurring estrogen.
- It modulates pituitary secretion and is vital for female reproductive system development.
✔️ Side Effects of Oestrogel
- Varied side effects include headaches, breast pain, nausea, abdominal cramps, and more.
- Report severe symptoms to your doctor.
✔️ Quick Suggestions:
- Alleviates menopausal symptoms.
- Maintains bone density, preventing osteoporosis.
- Supports overall hormonal balance.
- The lowest effective dose of Oestrogel should be used for maintenance therapy.
- Treatment duration should be for the shortest effective period, commonly up to 5 years.
- There should be no arbitrary limitation in dosage points if the risk is annually assessed.
- In women with an intact uterus, co-administration of a progestogen is essential to prevent endometrial hyperplasia.
- Oestrogel 0.06% is available in a tube pack that includes a ruler to facilitate the tailoring of the daily dose.
✔️ Indications:
- Moderate to severe vasomotor symptoms associated with menopause.
- Prophylaxis of osteoporosis in postmenopausal women.
- Hypogonadism.
- Atrophic vaginitis.
✔️ Pharmacology
- Oestrogens, such as the one present in Oestrogel, modulate the pituitary gland's secretion of gonadotrophins—luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
- This modulation occurs through a negative feedback system.
- Oestrogens are essential for the development and proper functioning of the female reproductive organs.
- They contribute to the maintenance of these organs throughout a woman's life.
- Oestrogens are responsible for the development of secondary sexual characteristics in females, such as breast development and distribution of body fat.
- Through negative feedback, oestrogens help regulate the secretion of gonadotrophins (LH and FSH) from the pituitary gland.
- This regulation is crucial for the menstrual cycle and reproductive processes.
✔️ Dosage & Administration:
- The dosage is measured using the ruler on the tube.
- Half ruler (1.25g of gel) is one application.
- Apply once daily to one arm, from the wrist to the shoulder.
- It is not necessary to massage or rub Oestrogel.
- Do not apply to the breasts.
- The gel typically dries within 2-5 minutes.
- To prevent the spread of medication to others, it is important to wash hands with soap and water after applying Oestrogel.
- Consult your doctor for personalized advice.
✔️ Interaction
- Various drug interactions, including those affecting CYP1A2 and CYP3A4 enzymes.
- Consult your doctor regarding concomitant medications.
✔️ Contraindications
- Hypersensitivity.
- Undiagnosed vaginal bleeding.
- Thrombophlebitis or thromboembolic disorders.
- Breast carcinoma (except in selected metastatic cases).
- Oestrogen-dependent tumor.
- Porphyria.
- Pregnancy.
✔️ Pregnancy & Lactation
- Therapy is not indicated during pregnancy.
- Limited data; consult your doctor.
- Not indicated for females of reproductive potential during breastfeeding.
✔️ Precautions & Warnings
- Conditions exacerbated by fluid retention, hypercalcemia, cerebrovascular disorders, coronary artery disease, gall bladder diseases, and lipid effects.
- Dosage reduction in hepatic impairment.
- Caution in lactation.
✔️ Storage Conditions
Store in a cool (below 30°C) and dry place, away from light & children.
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