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Premarin Conjugated Estrogen Vaginal Cream, containing Conjugated estrogens in the Hormone Replacement Therapy category, is used to address vaginal symptoms like itching, inflammation, dryness, and thinning due to estrogen deficiency (atrophic vaginitis). It also targets itching and inflammation in the genital area, such as the vulva and vaginal orifice (kraurosis vulvae), and aids in alleviating moderate to severe dyspareunia arising from menopause-related genital pain.
Notify your doctor of breast changes (pain, tenderness, discharge, lump growth), heavy menstrual bleeding, leg swelling/redness, sudden chest pain, or breathing difficulty after using Premarin Cream.
Be cautious with alcohol consumption while using this medicine, as interactions may occur. Consult your doctor for more information.
Unsafe for pregnancy (Category X drug). Not recommended during pregnancy due to potential harm to the fetus. Inform your doctor if you're pregnant or planning pregnancy for alternative options.
Unsafe during breastfeeding, as it can pass into breast milk and affect milk production. Consult your doctor before starting Premarin Cream if breastfeeding; they may recommend stopping breastfeeding during treatment.
Not applicable; Premarin Cream is unlikely to affect your ability to drive.
Use with caution in severe kidney diseases. Inform your doctor about your kidney disease history for possible dose adjustments or alternative prescriptions.
Unsafe for patients with liver diseases. Inform your doctor of any history of liver disease before using Premarin Cream.
Conjugated Estrogen, a blend of female sex hormones, prevents menopause-related symptoms like hot flashes, night sweats, and mood swings, and guards against osteoporosis.
Less serious, but common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps/bloating, nausea and vomiting, hair loss, fluid retention, vaginal yeast infection, reactions from Premarin Vaginal Cream such as vaginal burning, irritation, and itching.
Vaginal Atrophy
Post-menopausal symptoms
Endogenous estrogens play a crucial role in shaping the female reproductive system and secondary sexual characteristics. While estrogen levels continually shift through metabolic processes, the most influential intracellular estrogen is estradiol, which surpasses estrone and estriol in receptor potency. In menstruating women, the primary source of estrogen—generating 70 to 500 mcg of estradiol daily—stems from the ovarian follicle, with production varying based on the menstrual phase.
Following menopause, endogenous estrogen primarily arises from the peripheral tissue conversion of adrenal cortex-secreted androstenedione into estrone. This results in the abundance of estrone and its sulfate-conjugated form, estrone sulfate, in postmenopausal women.
Estrogens function by binding to nuclear receptors within estrogen-responsive tissues, with two types of estrogen receptors recognized, their presence varying among tissues. Circulating estrogens regulate the secretion of pituitary gonadotropins—luteinizing hormone (LH) and follicle-stimulating hormone (FSH)—via negative feedback. In postmenopausal women, estrogens act to reduce elevated gonadotropin levels.
Menopausal Vasomotor Symptoms, Atrophic Vaginitis/Kraurosis Vulvae:
Female Hypogonadism:
Osteoporosis Prophylaxis:
Prostate Cancer Palliation:
Female Castration/Primary Ovarian Failure:
Breast Cancer Palliation:
Abnormal Uterine Bleeding:
Premarin Cream Application:
Your doctor will determine the suitable dose and treatment duration based on your age, weight, and health condition.
All medications can interact differently for each individual. It's crucial to discuss potential interactions with your doctor before starting any new medicine.
Interaction with Alcohol: The interaction with alcohol is unknown. Consult your doctor before consuming alcohol while on this medication.
Interaction with Specific Medicines: Certain medicines like Thalidomide, Acarbose, Lenalidomide, and Carfilzomib may interact with this medication. Your doctor should provide guidance on these interactions.
Disease Interactions:
Abnormal Vaginal Bleeding: Use with caution in cases of previous abnormal vaginal bleeding, especially for prolonged use. Diagnostic tests should be conducted to determine the cause before starting estradiol therapy.
Estrogen-Dependent Tumor: Not recommended for patients with tumors caused by abnormal estrogen levels in the body (such as endometrial or breast tumors). Diagnostic tests are advised before starting treatment.
Hypertension (High Blood Pressure): Extreme caution is required for patients with high blood pressure. The risk of heart and blood vessel complications is high. Dose adjustment and safety monitoring are necessary.
Hepatic Neoplasms (Liver Cancer): Not recommended if liver cancer is suspected. The treatment course will be determined by your doctor.
Food and Lab Interactions: Specific food and lab interactions are not available in this information.
This list may not cover all possible interactions. It's essential to consult your doctor about potential drug interactions, especially considering your current medications and medical history.
In case of pregnancy during Conjugated Estrogens treatment, cease medication promptly. Most epidemiological studies conducted so far, focusing on unintentional fetal exposure to estrogens, have not revealed teratogenic or fetal toxicity effects. This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
Keep away from light and heat in a dry area. Keep out of children's reach.
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