Valestra 2mg Tablet | Female Sex Hormones
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Valestra 2mg Tablet

Generic: Estradiol

Type: Tablet

Pack Size: 10 Pcs

  • Provides relief from symptoms that occur after menopause in postmenopausal women
  • Prevents osteoporosis in post-menopausal women

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Discount Price: ৳ 182.4
MRP: ৳ 190 4% Off

⪼ Save  ৳: 7.6  in this Product


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✅ Description:

Valestra 2mg Tablet contains Estradiol, a member of the estrogen group.

  • Relief from postmenopausal symptoms.
  • Prevention of osteoporosis in postmenopausal women.

When not to use:

  • Allergy to Estradiol.
  • History of or current breast/endometrial cancer.
  • Thrombosis (blood clot in a vein).
  • Unusual vaginal bleeding.
  • Untreated endometrial hyperplasia.
  • Lung disease (e.g., pulmonary embolism).
  • Heart disease (e.g., heart attack/heart block).
  • Liver disease (e.g., benign liver tumor).

Common Side Effects:

  • Headache
  • Nausea
  • Leg cramps
  • Abdominal/pelvic pain
  • Unscheduled bleeding/spotting
  • Asthenia (feeling of weakness)
  • Rash/itching

Regular consultation with a doctor is advisable.

  • Report worsening of symptoms or any concerning side effects.
  • Prior consultation with a doctor is necessary for individuals with conditions like fibroids, endometriosis, epilepsy, otosclerosis, kidney problems, and lung problems (e.g., asthma).
  • Not recommended for use in pregnant or breastfeeding women.
  • Not indicated for children and adolescents; intended for postmenopausal women.
  • Caution is advised in elderly women (aged 60 years and above) due to the potential increased risk of heart disease.
  • Regular consultation with a doctor is advisable.
  • Report worsening of symptoms or any concerning side effects.

Safety Advices


Alcohol
UNSAFE

You are recommended not to consume alcohol along with Valestra 2mg Tablet to avoid unpleasant side effects.


Pregnancy
SAFE IF PRESCRIBED

Valestra 2mg Tablet is not recommended during pregnancy as it may harm the baby and cause serious complications for the baby and mother.


Breastfeeding
SAFE

Valestra 2mg Tablet is not recommended for breastfeeding mothers as it is known to cause harm to the baby.


Driving
SAFE

It is not known to cause any side effects which may affect driving,


Kidney
CAUTION

Valestra 2mg Tablet should be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.


Liver
CAUTION

Valestra 2mg Tablet should be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

Similar Products

✔️ Hypoestrogenism:
  • Definition: Hypoestrogenism refers to a condition characterized by lower-than-normal levels of estrogen, a key female sex hormone.
  • Significance: Abnormalities in estrogen levels can lead to various health issues, including infertility, bone loss, and lipid (fat) metabolism abnormalities.
  • Impact: Hypoestrogenism is associated with conditions where estrogen production or activity is diminished, affecting reproductive health, bone density, and lipid balance.
✔️ Hormone Replacement Therapy (HRT):
  • Purpose: HRT is a medical treatment designed to alleviate symptoms associated with menopause, which occurs when natural hormone levels decline.
  • Hormones Involved: Typically involves replacing estrogen and, in some cases, progestin (a synthetic form of progesterone) to balance hormonal levels.
  • Symptom Relief: HRT is used to manage symptoms like hot flashes, vaginal dryness, and mood changes that occur during menopause.
  • Bone Health: In postmenopausal women, HRT may also help prevent osteoporosis by addressing the decline in estrogen levels.
✔️ Osteoporosis:
  • Definition: Osteoporosis is a medical condition characterized by weakened and porous bones, making them more susceptible to fractures.
  • Cause: The disease results from an imbalance between the formation of new bone and the resorption of existing bone.
  • Risk Factors: Aging, hormonal changes (such as decreased estrogen in menopause), and certain medical conditions contribute to the development of osteoporosis.
  • Consequences: Fragile bones increase the risk of fractures, especially in the hip, spine, and wrist.
✔️ Uses:

Hormonal replacement therapy, Hypoestrogenism (estrogen deficiency), Osteoporosis (thinning of bones), Symptoms associated with menopause (itching, dryness in vagina, hot flushes)

✔️ How does Valestra 2mg Tablet work?

Valestra 2mg Tablet contains a precursor of ovarian hormones responsible for menstruation and reproduction in women. It replaces the natural Estradiol hormone in the body, helping maintain adequate hormone levels. This provides relief from vasomotor symptoms, such as hot flashes, in post-menopausal women.

✔️ Quick Suggestions:
  • Regular Exercise and Physical Activity minimize hot flashes, Improve sleep, and strengthen bones with weight-bearing exercises.
  • Include aerobics, yoga, and activities like tai chi for overall well-being.
  • Wear loose clothes before bedtime.
  • Sleep in a cool, well-ventilated room.
  • Aim for a minimum of 8 hours of sleep.
  • Avoid or limit caffeine-containing beverages, alcohol, and spicy foods, known triggers for hot flashes.
  • Be stress-free to alleviate mood swings caused by hormonal fluctuations.
  • Quitting smoking can Reduce hot flashes, and lower the risk of chronic conditions such as heart disease, stroke, and cancer.
✔️ Indications:

Valestra 2mg Tablet is indicated for the short-term treatment of climacteric complaints following the cessation of monthly bleeding. It is also prescribed for deficiency symptoms after oophorectomy or radiological castration for non-carcinomatous diseases. These symptoms include hot flashes, outbreaks of sweat, sleep disturbances, depressive moods, irritability, headaches, and dizziness.

Additionally, Valestra 2mg Tablet exhibits a favorable influence on bladder irritation, which is not uncommon during the climacteric period. It also addresses signs of cutaneous and mucosal involution, particularly in the genital region, which typically occurs with advancing age.

✔️ Pharmacology

Valestra 2mg Tablet is a naturally occurring estrogen. Estrogens play a crucial role in the development and maintenance of the female reproductive system and secondary sexual characteristics. They modulate the pituitary secretion of gonadotrophins, LH (luteinizing hormone), and FSH (follicle-stimulating hormone) through a negative feedback system.

✔️ Dosage & Administration:

Adult Dose Recommendations:

Vulvar and Vaginal Atrophy in Menopause:

  • Dose: 1-2 mg
  • Route: Oral
  • Frequency: Once daily
  • Duration: For 3 weeks, followed by 1 week off

Prevention of Osteoporosis:

  • Dose: 0.5 mg
  • Route: Oral
  • Frequency: Once daily
  • Duration: For 3 weeks, followed by 1 week off

Metastatic Breast Cancer:

  • Dose: 10 mg
  • Route: Oral
  • Frequency: Every 8 hours (q8hr)
  • Duration: For 3 months

Prostate Cancer:

  • Dose: 1-2 mg
  • Route: Oral
  • Frequency: Every 8 hours (q8hr)
  • Duration: At least 3 months (? indicates uncertainty)
✔️ Directions for Use of Valestra 2mg Tablet
  • Take Valestra 2mg Tablet as advised by your physician.
  • Swallow the medicine with a glass of water.
  • Do not crush or chew the medicine.
  • Your doctor will decide the correct dose and duration for you based on your age, body weight, and the specific disease condition being treated.
✔️ Interaction
  • CYP1A2 and CYP3A4 Inducers: Concomitant use of CYP1A2 and CYP3A4 inducers such as aminoglutethimide, carbamazepine, phenobarbital, and rifampin may decrease the effects of estradiol.
  • Enhancement of Effects: Estradiol may enhance the effects of hydrocortisone and prednisolone when used together.
✔️ Contraindications
  • Hypersensitivity: Estradiol is contraindicated in individuals with hypersensitivity to any of its components.
  • Undiagnosed Vaginal Bleeding: Contraindicated in cases of undiagnosed vaginal bleeding.
  • Thrombophlebitis or Thromboembolic Disorders: Contraindicated in individuals with a history of thrombophlebitis or thromboembolic disorders.
  • Breast Carcinoma: Contraindicated, except in selected patients being treated for metastatic disease.
  • Estrogen-Dependent Tumor: Contraindicated in cases of estrogen-dependent tumors.
  • Porphyria: Contraindicated in individuals with porphyria.
  • Pregnancy: Contraindicated during pregnancy.
✔️ Pregnancy:

Therapy with Estradiol is not indicated for use during pregnancy. There is a lack of data regarding its use in pregnant women. Epidemiologic studies and meta-analyses have not found an increased risk of genital or nongenital birth defects, including cardiac anomalies and limb-reduction defects, following exposure to combined hormonal contraceptives (estrogen and progestins) before conception or during early pregnancy. However, the use of Estradiolduring pregnancy is not recommended

✔️ Lactation:

Estradiol therapy is not indicated for use in females of reproductive potential who are breastfeeding. Estrogens present in human milk can reduce milk production in breastfeeding females. While reduction can occur at any time, it is less likely to occur once breastfeeding is well-established.

✔️ Precautions & Warnings

Potential Risks and Effects:

  • Increased blood pressure.
  • Risk of venous thromboembolism.
  • Increased risk of breast cancer.
  • Benign hepatic adenoma.
  • Endometrial cancer.
  • Enlargement of preexisting uterine leiomyomata (fibroids).

Conditions Exacerbated by Fluid Retention:

  • Certain medical conditions may worsen with fluid retention.

Other Conditions to Consider:

  • Hypercalcemia (high calcium levels).
  • Cerebrovascular disorders.
  • Coronary artery disease.
  • Gall bladder diseases.
  • Lipid effects.
  • Familial defects of lipoprotein metabolism.

The dosage may need to be reduced in individuals with hepatic impairment (liver-related issues).

  • Caution is advised during lactation as the drug enters breast milk.
  • The use of the drug is not recommended in children.
✔️ Storage Conditions

Store in a cool and dry place away from sunlight

Frequently Asked Questions (FAQ)

No, Valestra 2mg Tablet should not be taken if you are undergoing surgery. You should inform your doctor, and he might ask you to stop hormone replacement therapy about 4 to 6 weeks before surgery to reduce the risk of blood clots.

Do not use Valestra 2mg Tablet if you are allergic to peanuts, have unusual vaginal bleeding, have/had any cancer (breast or uterus cancer), or undergoing any other estrogen treatment. Tell your doctor if you had a heart attack, stroke, blood clot, or liver problems, if you are pregnant, breastfeeding, or planning to get pregnant.

Adults—1 capsule once a day, in the evening.

Estrogen Production: The ovaries, which are part of the female reproductive system, start producing estrogen during puberty. Effects on Breast Tissue: Estrogen influences the development of secondary sexual characteristics. It stimulates the growth and development of glandular tissue and fat deposits in the breasts. Breast Enlargement: The accumulation of fat in the connective tissue of the breasts, along with the development of glandular tissue, leads to an increase in breast size. Changes in Breast Structure: Estrogen also promotes the growth of ductal tissue within the breasts.

The treatment for estrogen deficiency depends on various factors, including the underlying cause, the age of the individual, and whether they have undergone menopause. Here are some common approaches to treating estrogen deficiency: Hormone Replacement Therapy (HRT): HRT involves replacing the deficient hormones, such as estrogen and sometimes progesterone. Bio-identical hormones, including estradiol and estriol, may be used. These hormones have a molecular structure identical to the hormones produced by the ovaries. Estrogen Replacement Therapy (ERT): ERT specifically focuses on replacing estrogen. It is commonly used to alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and mood swings. Bio-identical Hormones: Bio-identical hormones are synthesized to be structurally identical to the hormones naturally produced by the body. They are often used in HRT to provide a more personalized approach. Progestin or Natural Progesterone: In women with an intact uterus, progestin or natural progesterone may be prescribed along with estrogen to prevent endometrial hyperplasia (overgrowth of the uterine lining). Lifestyle Modifications: Dietary changes, regular exercise, and a healthy lifestyle can contribute to overall well-being.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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