Tetraben 25 | Hyperkinetic Motor Disorders | Huntington's Chorea
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Tetraben 25mg Tablet 10pcs

Generic: Tetrabenazine

Type: Tablet

Pack Size: 10 Pcs

Tetrabenazine is used to treat hyperkinetic motor disorders, such as jerky, irregular, and uncontrollable movements. These movements are associated with Huntington's chorea, which is an inherited neurodegenerative disease. By targeting the underlying mechanisms in the brain, tetrabenazine helps to alleviate these abnormal movements and improve the quality of life for individuals affected by Huntington's chorea.


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✅ Description:

Huntington's disease is a hereditary neurological condition characterized by the degeneration of nerve cells in the brain. It affects various aspects of an individual's functioning, including movement, cognition, and behavior. Symptoms typically develop gradually and worsen over time. These may include involuntary jerking movements, muscle problems, cognitive impairment, psychiatric disorders, mood swings, obsessive-compulsive behaviors, and eventually, difficulties with daily activities.

Treatment for Huntington's disease involves a multidisciplinary approach to address its various symptoms and challenges. Diagnostic tests such as brain imaging scans help in identifying affected brain structures and ruling out other conditions. Genetic counseling is crucial to assess the familial history of the disease and develop a tailored treatment plan.

Medications are prescribed to manage symptoms such as involuntary movements and cognitive impairment. However, these drugs may have limited effectiveness and can potentially exacerbate certain symptoms like suicidal tendencies and insomnia. Psychotherapy plays a vital role in helping patients cope with the emotional and psychological aspects of the disease, facilitating communication, and enhancing coping strategies.

Individuals experiencing changes in movements, mood swings, cognitive decline, or suicidal thoughts should seek medical evaluation to determine if they are eligible for treatment. It's essential to differentiate Huntington's disease from other conditions with similar symptoms through appropriate diagnostic tests.

While there may be side effects associated with medications used to manage Huntington's disease, post-treatment guidelines focus on symptom management and improving quality of life. It's important to understand that Huntington's disease is a progressive condition, and complete recovery is not possible. Patients may experience suppression of symptoms with treatment, but there is always a risk of symptom exacerbation triggered by various factors.

Overall, managing Huntington's disease requires ongoing medical monitoring, adherence to treatment plans, and support from healthcare professionals, caregivers, and support networks to enhance the well-being of affected individuals.

Safety Advices


Alcohol
UNSAFE

It is advisable to avoid alcohol consumption while taking Tetraben 25mg Tablet, as it may exacerbate feelings of abnormal sleepiness induced by the medication.


Pregnancy
UNSAFE

Use Tetraben 25mg Tablet during pregnancy only if deemed necessary by your doctor. Consult your healthcare provider before taking the medication if you are pregnant or planning to become pregnant.


Breastfeeding
UNSAFE

Avoid using Tetraben 25mg Tablet while breastfeeding, as it is not recommended for lactating women. Consult your doctor before taking the medicine if you are breastfeeding.


Driving
CAUTION

Refrain from driving or operating machinery if you experience drowsiness after taking Tetraben 25mg Tablet. This medication may cause drowsiness, impairing your ability to safely perform such activities.


Kidney
CONSULT YOUR DOCTOR

Tetraben 25mg Tablet is not recommended for use in patients with kidney disorders. Consult your doctor before taking this medication if you have kidney problems.


Liver
CONSULT YOUR DOCTOR

Use Tetraben 25mg Tablet with caution if you have liver problems, including mild, moderate, or severe hepatic disorders. Consult your doctor before starting the medication if you have any liver conditions.

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✔️ Uses of Tetraben 25mg Tablet

Huntington's disease

✔️ How does Tetraben 25mg Tablet work?

Tetrabenazine works by decreasing the levels of certain chemicals in the body that cause abnormal movements.

✔️ Side Effects of Tetraben 25mg Tablet
  • Nausea
  • Fatigue
  • Depression
  • Sleepiness
  • Akathisia
  • Insomnia
  • Anxiety
✔️ Quick Suggestions:
  • Take Tetrabenazine exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting your doctor.
  • Do not break, chew, or crush the tablet. Swallow it whole with plenty of water.
  • Take the medication at the same time each day to help remember. Consistency in timing ensures a steady level of the medication in your body.
  • Be careful when standing up from a sitting or lying position to prevent dizziness, which can be a side effect of Tetrabenazine.
  • If your symptoms do not improve or worsen while taking Tetrabenazine, consult your doctor promptly. It's essential to keep your doctor informed of any changes in your condition.
  • Be vigilant for any changes in mood or behavior while taking Tetrabenazine. If you experience any unusual mood swings or thoughts of self-harm, seek immediate medical attention.
✔️ Indication of Tetraben 25mg Tablet

Tetrabenazine is used to treat the chorea that comes with Huntington's disease.

✔️ Pharmacology
  • Tetrabenazine reversibly inhibits human vesicular monoamine transporter type 2 (VMAT2), which leads to decreased uptake of monoamines (such as dopamine, serotonin, norepinephrine, and histamine) into synaptic vesicles.
  • This inhibition results in the depletion of monoamine stores from nerve terminals.
  • The mechanism is similar to reserpine but with less peripheral activity and is shorter-acting.
✔️ Dosage of Tetraben 25mg Tablet

Here are the general dosing considerations for Tetrabenazine:

Chronic Daily Dose for Huntington's Disease:

  • The chronic daily dose of Tetrabenazine used to treat chorea associated with Huntington's disease (HD) is determined individually for each patient.
  • Tetrabenazine therapy should be titrated slowly over several weeks to identify a dose that reduces chorea and is tolerated.
  • Tetrabenazine can be administered without regard to food.

Individualization of Dose:

  • Dosing recommendations up to 50 mg per day:
    • Starting dose: 12.5 mg per day once in the morning.
    • After one week, increase to 25 mg per day given as 12.5 mg twice a day.
    • Titrate up slowly at weekly intervals by 12.5 mg daily to identify a tolerated dose.
    • If a dose of 37.5 to 50 mg per day is needed, administer a three-times-a-day regimen.
    • The maximum recommended single dose is 25 mg.
    • If adverse reactions occur, such as akathisia, restlessness, parkinsonism, depression, insomnia, anxiety, or sedation, stop titration and reduce the dose.

Dosing Recommendations Above 50 mg per day:

  • Patients requiring doses greater than 50 mg per day should be genotyped to determine their CYP2D6 metabolizer status (poor metabolizers or extensive metabolizers).
  • Dose individualization based on metabolizer status:
    • Extensive and intermediate metabolizers (EMs or IMs) should be titrated up slowly at weekly intervals by 12.5 mg daily.
    • Doses above 50 mg per day should be given in a three times-a-day regimen.
    • The maximum recommended daily dose is 100 mg, and the maximum recommended single dose is 37.5 mg.
    • If adverse reactions occur, such as akathisia, parkinsonism, depression, insomnia, anxiety, or sedation, stop titration and reduce the dose.

Considerations:

  • Carefully monitor patients for adverse reactions during titration.
  • Consider withdrawal of Tetrabenazine or the initiation of other specific treatments (e.g., antidepressants) if adverse reactions persist.
✔️ Administration of Tetraben 25mg Tablet

Take Tetraben 25mg Tablet as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

✔️ Interaction
  • Tetrabenazine should not be given concurrently with or within 14 days of discontinuation of MAOI therapy due to the risk of serotonin syndrome.
  • It blocks the action of reserpine and decreases the effects of levodopa, potentially worsening parkinsonism.
  • There is an increased risk of extrapyramidal side effects when Tetrabenazine is given with amantadine, metoclopramide, or antipsychotics.
✔️ Contraindications

Tetrabenazine is not recommended for the following patients:

  • Patients who are actively suicidal, or those who have depression that is untreated or inadequately treated
  • Hepatic impairment is a condition in which the liver is damaged.
  • Monoamine oxidase inhibitors are drugs that prevent monoamine oxidase from forming (MAOIs). XENAZINE should not be used in conjunction with an MAOI or within 14 days after stopping MAOI therapy.
✔️ Pregnancy & Lactation
  • There is limited data on the developmental risk associated with Tetrabenazine use in pregnant women.
  • Administration of Tetrabenazine to rats throughout pregnancy and lactation increased stillbirths and postnatal offspring mortality.
  • The potential risks and benefits of Tetrabenazine use during pregnancy should be carefully considered, and treatment should only be initiated if necessary.

Lactation:

  • There is no data on the presence of Tetrabenazine or its metabolites in human milk, its effects on breastfed infants, or milk production.
  • The developmental and health benefits of breastfeeding should be weighed against the potential adverse effects on the breastfed infant or underlying maternal condition.
✔️ Precautions & Warnings
  • Tetrabenazine may exacerbate symptoms of parkinsonism, so caution should be exercised, especially when engaging in activities that require mental alertness, such as driving or operating machinery.
  • Pregnant patients should use Tetrabenazine with caution, and the potential risks and benefits should be discussed with a healthcare provider.
  • Patients with Huntington's disease may have an increased risk of depression and suicidal thoughts or behavior (suicidality) while taking Tetrabenazine.
  • It's essential to monitor for the emergence or worsening of depression, suicidality, or unusual changes in behavior, especially in patients with a history of depression or prior suicide attempts or ideation.
✔️ Storage Conditions
  • Keep Tetraben 25mg Tablet out of reach of children
  • Store Tetraben 25mg Tablet at room temperature
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