Abetis 10mg Tablet 50pcs Box

Uses of Abetis 10mg Tablet

• Hypertension
• Diabetic Nephropathy

How does Abetis 10mg Tablet work?

Abetis 10mg Tablet relaxes the blood vessels by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently.

Side Effects of Abetis 10mg Tablet

Common side effects in adults include dizziness, headache, diplopia, ataxia, nausea, blurred vision, somnolence, pharyngitis, and rash. In children, side effects include vomiting, diarrhea, infection, fever, abdominal pain, and tremor. Clinical trials reported adverse reactions similar to placebo, with dizziness being the only reaction occurring in more than 1% of patients treated with Abetis compared to placebo.

Quick Suggestions:

• Take Abetis 10mg Tablet at the same time every day to help you remember to take it.
• Abetis 10mg Tablet can make you feel dizzy for the first few days. Rise slowly if you have been sitting or lying down for a long time.
• Your doctor may get regular tests done to monitor the level of urea, creatinine, and potassium in your blood.
• Avoid taking anti-inflammatory medicines such as ibuprofen along with this medicine without consulting your doctor.
• Abetis 10 mg Tablet may increase the level of potassium in the blood. Avoid taking potassium supplements and potassium-rich foods such as banana fruit juice, coconut water, and broccoli.
• Do not take Abetis 10 mg Tablet if you are pregnant or breastfeeding.
• Do not stop taking it suddenly without talking to your doctor.

Indication of Abetis 10mg Tablet

Abetis is used to treat hypertension and can be administered alone or with other antihypertensive medications.

Pharmacology

Olmesartan, the active ingredient in Abetis, inhibits the vasoconstrictor effects of angiotensin II by selectively blocking its binding to the AT1 receptor in vascular smooth muscle. This prevents vasoconstriction, aldosterone release, cardiac stimulation, and renal sodium reabsorption, leading to lowered blood pressure. Unlike ACE inhibitors, olmesartan does not affect the response to bradykinin.

Dosage & Administration of Abetis 10mg Tablet

The dosage should be individualized. The usual starting dose is 20 mg once daily, which can be increased to 40 mg after two weeks if needed. Doses above 40 mg do not show additional benefits. No dosage adjustments are needed for elderly patients, those with moderate to marked renal impairment, or those with hepatic dysfunction. For patients with possible intravascular volume depletion, a lower starting dose should be considered. Abetis can be taken with or without food. Safety and effectiveness in pediatric patients have not been established.

Interaction

No significant drug interactions have been reported with digoxin or warfarin. The bioavailability of olmesartan is not significantly altered by antacids. Abetis is not metabolized by the cytochrome P450 system, so interactions with drugs affecting these enzymes are unlikely. However, NSAIDs, including COX-2 inhibitors, may reduce renal function and attenuate the antihypertensive effect of olmesartan. Regular monitoring of renal function is recommended for patients taking both Abetis and NSAIDs

Contraindications

Olmesartan is contraindicated in patients with hypersensitivity to any component of the product.

Pregnancy & Lactation

Abetis is classified as Pregnancy Category C. It should be discontinued as soon as pregnancy is detected due to the risk of injury or death to the fetus. It is not known if olmesartan is excreted in human milk, but it is present in low concentrations in rat milk. A decision should be made to discontinue either nursing or the drug, considering the drug's importance to the mother.

Precautions & Warnings

Renal function changes may occur in susceptible individuals, particularly those with severe congestive heart failure. Monitoring of renal function is advised, as treatment with olmesartan may be associated with oliguria, progressive azotemia, and rare cases of acute renal failure and death.

Storage Conditions:

Abetis 10 should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children.