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Bisoren Plus 5mg+6.25mg Tablet 1 Strip
Bisoren Plus 5 (Bisoprolol Fumarate 5mg + Hydrochlorothiazide 6.25mg)
- Primarily prescribed to manage high blood pressure (hypertension).
- May also be used in treating congestive heart failure and angina pectoris.
- This is a fixed-dose combination medicine used for blood pressure control.
- Avoid stopping this medication abruptly, as it may cause a sudden spike in blood pressure, increasing the risk of heart attack or stroke.
- May cause dizziness; rise slowly from sitting or lying positions.
- Can mask signs of low blood sugar in diabetic patients—regular blood sugar monitoring is advised.
- May lead to dehydration; drink sufficient fluids and alert your doctor if symptoms like excessive thirst or dry mouth appear.
- Pregnancy Category C: Use only if the benefits outweigh potential risks.
- Breastfeeding: Use caution; may be secreted into breast milk.
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✅ Description:
Bisoren Plus 5 contains Bisoprolol, a beta-1 selective blocker, and Hydrochlorothiazide, a thiazide-type diuretic.
- Bisoprolol works on the heart to reduce its workload and improve pumping efficiency.
- Hydrochlorothiazide helps lower blood pressure by promoting the removal of excess salt and water through the kidneys. It also helps to relax blood vessels over time.
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✔️ Directions for Use:
- Take the medicine exactly as your doctor instructs.
- Swallow the tablet whole; do not chew, break, or crush.
- Can be taken with or without meals, but it’s best to take it at a consistent time daily.
✔️ Side Effects of Bisoren Plus 5mg+6.25mg Tablet
- Nausea, constipation, and fatigue
- Headache, dizziness, and diarrhea
- Cold hands and feet, slower heart rate
- Elevated blood uric acid levels
- Reduced potassium and magnesium levels in the blood
- Increased blood calcium levels
- Impaired glucose tolerance and altered lipid profiles
✔️ Extended Side Effects of Bisoren Plus 5mg+6.25mg Tablet
- Bisoprolol-related (1–10%): Joint pain, weakness, cough, dry mouth, sleep disturbances, shortness of breath, peripheral swelling, cold extremities, sinus infections
- Hydrochlorothiazide-related: Stomach upset, appetite loss, lightheadedness, electrolyte imbalances (e.g., hypokalemia, hypercalcemia), increased blood sugar, cholesterol, and uric acid levels
- Rare but serious reactions: Allergic reactions, skin rashes (including Stevens-Johnson syndrome), severe electrolyte disturbances, arrhythmias, or worsening heart conditions
- Potentially fatal: AV block, severe bradycardia, bronchospasm, severe hypotension, rebound angina, or myocardial infarction if stopped abruptly
✔️ Mode of Action (Pharmacology): Bisoren Plus 5mg+6.25mg Tablet
Bisoprolol: A cardioselective beta-1 blocker with no notable intrinsic sympathetic activity. Reduces heart rate and contractility.
Hydrochlorothiazide: A diuretic that blocks sodium reabsorption in the distal kidney tubules, promoting excretion of sodium, water, potassium, and hydrogen ions.
✔️ Dosage and Administration of Bisoren Plus 5mg+6.25mg Tablet
- Adults: Start with 2.5 mg Bisoprolol / 6.25 mg Hydrochlorothiazide once daily. Dosage may be adjusted after two weeks based on response.
Maximum Dose: 20 mg Bisoprolol / 12.5 mg Hydrochlorothiazide per day. - Elderly: Typically, no specific dose adjustment needed, but close monitoring is required.
Administration: Can be taken with or without food.
✔️ Drug Interactions
Bisoprolol:
- May intensify bradycardia with digitalis
- Interaction with Class I antiarrhythmics (e.g., quinidine) may slow AV conduction
- NSAIDs may reduce their blood pressure-lowering effects
- Risk of excessive sympathetic inhibition with drugs like reserpine
Hydrochlorothiazide:
- Can increase lithium toxicity
- May amplify the effects of other antihypertensives
- Raises the risk of low potassium with corticosteroids or beta-2 agonists
- May reduce the effects of anti-diabetic drugs
- Enhances the side effects of NSAIDs and some muscle relaxants
- Can worsen dehydration and cause fluid/electrolyte imbalances
✔️ Renal Dose Adjustment: Bisoren Plus 5mg+6.25mg Tablet
- Use caution in patients with kidney impairment.
- In patients with a creatinine clearance <40 mL/min, the half-life of bisoprolol may increase up to threefold.
- Monitor for the cumulative effects of hydrochlorothiazide.
✔️ Contraindications
- Acute heart failure or significantly low heart output
- Slow heart rate (sinus bradycardia), certain heart conduction blocks
- Cardiogenic shock, severe bleeding
- Asthma or other bronchospastic conditions
- Pregnancy (Category C – use only if needed)
✔️ Precautions
- Use with caution in patients with respiratory conditions, thyroid disorders, and poor circulation.
- Monitor blood sugar in diabetic patients—symptoms of hypoglycemia may be masked.
- Should be withdrawn gradually to avoid rebound effects.
- Use cautiously in breastfeeding; the drug may pass into breast milk.
✔️ Storage:
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
