Type: Tablet
Generic Name: Clonidine Hydrochloride 0.1 mg
Manufacturer: Navana Pharmacuticals Ltd.
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Indications of Clonipres 0.1 Tablet
Clonidine is indicated in Anxiety, Cancer pain, Generalized anxiety disorder, Hypertension, Hypertensive crisis, Menopausal flushing, Migraine, Panic disorder, Severe anxiety disorders, Social anxiety disorder
Pharmacology of Clonipres 0.1 Tablet
Clonidine stimulates α2-adrenoceptors in the brain stem which results in a reduced sympathetic outflow from the CNS, and a decrease in peripheral resistance, heart rate, BP, and renal vascular resistance.
Dosage & Administration of Clonipres 0.1 Tablet
Adults: The dose of Clonidine tablets must be adjusted according to the patient's individual blood pressure response. The following is a general guide to its administration.
Initial Dose: 0.1 mg tablet twice daily (morning and bedtime). Elderly patients may benefit from a lower initial dose.
Maintenance Dose: Further increments of 0.1 mg per day may be made at weekly intervals if necessary until the desired response is achieved. Taking the larger portion of the oral daily dose at bedtime may minimize transient adjustment effects of dry mouth and drowsiness. The therapeutic doses most commonly employed have ranged from 0.2 mg to 0.6 mg per day given in divided doses. Studies have indicated that 2.4 mg is the maximum effective daily dose, but doses as high as this have rarely been employed.
Interaction of Clonipres 0.1 Tablet
Increased hypotensive effect with other antihypertensives e.g. diuretics, β-blockers, vasodilators, C antagonists, and ACE inhibitors. Reduced antihypertensive effect and induced orthostatic hypotension with TCAs or neuroleptics with α-receptor blocking properties. Reduced therapeutic effect with NSAIDs.
Contraindications
Severe bradyarrhythmia was secondary to 2nd- or 3rd-degree AV block or sick sinus syndrome.
Side Effects of Clonipres 0.1 Tablet
Headache, dizziness, drowsiness, dry mouth, constipation, depression, anxiety, nausea, fatigue, anorexia, parotid pain, paraesthesia, delusional perception, sleep disturbances, vivid dreams, impotence and loss of libido, urinary retention or incontinence, orthostatic hypotension, itching or burning sensations in the eye, accommodation disorder, decreased lacrimation, fluid retention, pruritus and rashes (transdermal), bradycardia, other ECG disturbances, heart failure, hallucinations, cramp, Raynaud's syndrome, gynecomastia, transient abnormalities in LFTs.
Pregnancy & Lactation
Category C: Either study in animals has revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.
Precautions & Warnings
Patients with cerebrovascular disease, ischaemic heart disease including MI, occlusive peripheral vascular disorders (e.g. Raynaud's disease), or those with w/a history of depression. Avoid abrupt withdrawal. Renal impairment. Pregnancy and lactation.
Storage Conditions
Store between 20-25°C.
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