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Clonipres 0.1mg Tablet 1 Strip
Clonidine Hydrochloride 0.1 mg
- Hypertension (alone or with other antihypertensive agents)
- Menopausal Flushing
- Opioid Withdrawal
- Alcohol Withdrawal Syndrome
- Attention Deficit Hyperactivity Disorder (ADHD) (Extended Release as Monotherapy)
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â Description:
âī¸ Pharmacology
- Clonidine Hydrochloride stimulates alpha-adrenoceptors in the brainstem, reducing blood pressure within 30-60 minutes after oral administration.
- Maximum BP reduction occurs within 2-4 hours.
- Renal function remains stable; postural reflexes are intact, making orthostatic hypotension rare.
âī¸ Overdose Effects
â Symptoms:
- Severe hypotension, bradycardia, respiratory depression, hypothermia, sedation, weakness, abnormal reflexes, pinpoint pupils (miosis).
âī¸ Dosage & Administration
Adults (Hypertension)
- Initial dose: 0.1 mg twice daily (morning & bedtime)
- Elderly patients: May require a lower initial dose.
- Maintenance dose: Increase by 0.1 mg/day at weekly intervals if needed.
- Typical range: 0.2â0.6 mg/day (divided doses).
- Renal impairment: Adjust dosage & monitor closely.
Other Conditions
- ADHD:
- Immediate-Release (IR): 5 mcg/kg/day
- Extended-Release (ER): 0.1 mg/day for 8 weeks
- Menopausal Flushing: 0.1â0.4 mg daily
- Alcohol Withdrawal: 0.3â0.6 mg every 6 hours
đš Pediatric Use: Safety not well-established.
âī¸ Drug Interactions
- CNS depressants (e.g., alcohol, barbiturates, sedatives) â Enhanced drowsiness
- Tricyclic Antidepressants (TCAs) â May reduce the hypotensive effect, requiring a dose increase
- Digitalis, β-blockers, Calcium Channel Blockers â Risk of bradycardia & A.V. block
âī¸ đĢ Do not use in patients with:
- Hypersensitivity to Clonidine
âī¸ Side Effects
(Usually mild, improves with continued use)
- Common:
- Dry mouth, dizziness, drowsiness, sedation
- Constipation, nausea, diarrhea, abdominal pain
- Irritability, ear pain
âī¸ Pregnancy & Lactation
- Pregnancy: Category C â Avoid unless necessary
- Lactation: Passes into breast milk â Use caution
âī¸ Precautions & Warnings
- Do NOT discontinue suddenly â Can cause:
- Nervousness, agitation, headache, tremor, rapid BP rise
- High catecholamine levels
- Discontinuation: Reduce dose gradually over 2-4 days
- If using with β-blockers: Withdraw β-blocker first, then taper Clonipres
âī¸ Storage Conditions
- Store below 30°C, away from light & moisture
- Keep out of childrenâs reach
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