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Cilnidipine, a dihydropyridine calcium-channel blocker, works by binding to dihydropyridine sites on L-type voltage-dependent calcium channels, reducing calcium ion (Ca²⁺) influx into vascular smooth muscle cells. This action relaxes vascular smooth muscle and induces vasodilation. Additionally, Cilnidipine inhibits Ca²⁺ influx via N-type voltage-dependent calcium channels in sympathetic nerve cell membranes, reducing norepinephrine release from nerve terminals. This dual action may prevent the reflexive increase in heart rate often associated with blood pressure reduction.
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✅ Description:
Safety Advices
Alcohol
UNSAFE
Avoid consumption of alcohol while taking Duocard 5 as it could make you feel dizzier.
Pregnancy
CONSULT YOUR DOCTOR
Duocard 5 should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.
Breastfeeding
CONSULT YOUR DOCTOR
Duocard 5 should be used with caution in breastfeeding women as it may pass through the breast milk to the nursing infant. Therefore, consult your doctor before taking it.
Driving
CAUTION
Do not drive or operate any heavy tools or machines if you feel dizzy after taking Duocard 5.
CONSULT YOUR DOCTOR
Duocard 5 should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
CONSULT YOUR DOCTOR
Duocard 5 should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
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✔️ Uses of Duocard 5
✔️ How does Duocard 5 work?
✔️ Side Effects of Duocard 5
Common side effects include dizziness, flushing, headache, hypotension, peripheral edema, palpitations, gastrointestinal disturbances, increased urination frequency, lethargy, eye pain, and depression.
✔️ Quick Suggestions:
✔️ Indication of Duocard 5
Duocard is used to manage hypertension and offers protection to end organs. It has shown benefits in elderly patients, as well as in individuals with diabetes and albuminuria. Duocard is also increasingly recommended for patients with chronic kidney disease.
Hypertension refers to elevated blood pressure, which results from the force of blood being pumped from the heart against the walls of the blood vessels. Excessive pressure can damage the blood vessels and lead to complications.
Take medication only as advised by a registered physician.
✔️ Dosage & Administration of Duocard 5
- Adults: Take 5-10 mg once daily after breakfast. The maximum daily dose is 20 mg.
- Pediatric Patients: The safety of Cilnidipine has not been established.
- Elderly Patients: Begin treatment with the lowest dose (5 mg) due to increased susceptibility to hypotension.
Take medication only as advised by a registered physician.
✔️ Drug Interactions
Caution is advised when used with other antihypertensives, antipsychotics that lower blood pressure, quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, or erythromycin.
✔️ Cilnidipine should not be used in patients with:
- Known hypersensitivity to Cilnidipine or its ingredients.
- Cardiogenic shock.
- Recent myocardial infarction (MI) or acute unstable angina.
- Severe aortic stenosis.
✔️ Pregnancy & Lactation
- Cilnidipine is not recommended for pregnant women or those who may become pregnant.
- Nursing mothers should avoid Cilnidipine, but if its use is necessary, breastfeeding should be discontinued.
✔️ Duocard should be used with caution in:
- Patients with severe liver dysfunction.
- Patients with a history of serious adverse reactions to calcium channel blockers.
- The dosage should be reduced gradually when discontinuing treatment, under close supervision.
✔️ Storage Conditions
Store below 30°C, protected from light and moisture. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
