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Dydroton 25mg Tablet
Dydroton 25mg Tablet is used for Hypertension (high blood pressure) and Edema. It treats edema (fluid overload) associated with heart, liver, kidney, or lung disease
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✅ Description:
Chlorthalidone is a diuretic medication used to treat high blood pressure and reduce excess fluid accumulation in the body caused by various medical conditions, including heart, kidney, and liver problems. It works by increasing urine production, which helps eliminate extra water and salt from the body, thereby controlling blood pressure and reducing swelling due to fluid retention.
Common side effects of chlorthalidone may include headache, stomach upset, weakness, and dizziness. It can also lead to increased urination, which is one of the mechanisms by which it lowers blood pressure. Most of these side effects are temporary and tend to resolve on their own. If these side effects persist or worsen, it is advisable to consult a doctor.
Chlorthalidone can be taken with or without food, preferably at the same time each day for better consistency. It is usually prescribed for long-term use, and discontinuing the medication should be done only under the guidance of a healthcare provider.
This medication is not recommended if you have allergies to it. People with kidney or liver problems, as well as those with diabetes, should use chlorthalidone with caution. It's essential to inform your doctor about any other medications you are taking or any other medical conditions you may have. If you are pregnant or breastfeeding, consult with your healthcare provider before taking chlorthalidone.
Safety Advices
Alcohol
Consumption of alcohol is not recommended while you are taking Chlorthalidone as it may increase the risk of dizziness, low blood pressure, etc.
Pregnancy
Limited data suggest that Chlorthalidone may harm your developing fetus. If you are pregnant, consult your doctor to understand all risks and benefits associated with the use of this medicine.
Breastfeeding
Chlorthalidone may pass into the breast milk. Hence, consult your doctor if you are breastfeeding.
Driving
Avoid performing activities that require high mental alertness like driving vehicles or operating machines.
Kidney
CONSULT YOUR DOCTOR
Chlorthalidone can elevate blood urea and nitrogen compounds, causing azotemia, especially in those with prior severe kidney issues. Your doctor may perform kidney function tests, adjusting the dose as needed based on your condition.
Liver
CONSULT YOUR DOCTOR
Exercise caution when using Chlorthalidone with liver issues due to a higher risk of side effects. Your doctor may advise monitoring liver function and prompt reporting of symptoms like confusion or jaundice for immediate attention.
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✔️ Uses:
- Hypertension
- Oedema
✔️ How does Dydroton 25mg Tablet work?
Chlorthalidone works by increasing the excretion of water and sodium from the kidneys. This helps in controlling the blood pressure as well as reducing swelling due to fluid build-up.
✔️ Side Effects of Dydroton 25mg Tablet
- Low blood pressure
- Photosensitivity
- Constipation
- Diarrhea
- Loss of appetite
- Nausea
- Vomiting
- Headache
- Dizziness
- Blurred vision
- Restlessness
- Stomach discomfort
✔️ Quick Suggestions:
- Take Dydroton 25mg Tablet in the morning with breakfast to prevent nighttime urination.
- Be cautious as it can cause dizziness. Avoid activities like driving that require full attention until you understand its effects.
- Refrain from alcohol consumption while on this medication to avoid increased dizziness.
- Watch your sodium intake because it may lead to a sudden drop in blood sodium levels.
- Regularly monitor your blood pressure after starting Dydroton 25mg Tablet, and inform your doctor if it doesn't decrease.
- If you experience persistent dizziness, fatigue, or muscle weakness, notify your doctor.
✔️ Indication
✔️ Pharmacology
Chlortalidone is an oral, long-acting antihypertensive/diuretic that enhances the excretion of sodium and chloride ions and water by interfering with the transport of sodium ions across the renal tubular epithelium. The primary action is at the cortical diluting segment in the nephron of the loop of Henle.
✔️ Dosage & Administration of Dydroton 25mg Tablet
Adult Dose:
- Hypertension: 25-100 mg/day PO; usual range, 12.5-25 mg/day
- Edema: 50-100 mg/day PO or 100 mg PO every other day; not to exceed 200 mg/day
- Heart Failure: 12.5-25 mg/day PO; not to exceed 100 mg/day
Renal Dose:
- Renal impairment CrCl <10 mL/min: Ineffective; do not use CrCl >10 mL/min: Dose adjustment not necessary
Should be taken with food. Take during meals.
✔️ Interaction
- NSAIDs antagonize hypotensive action.
- Suppresses the action of oral anticoagulants.
- Increased risk of hypokalemia when corticosteroids are given concurrently.
- Potentially Fatal: Potentiates bone marrow suppression caused by anticancer drugs.
- Diuretic-induced volume depletion can potentiate aminoglycoside nephrotoxicity.
- Impairs the action of oral hypoglycemic agents.
- Enhances digitalis toxicity due to hypokalemia.
- Volume depletion enhances lithium toxicity, and conversely, sudden withdrawal of diuretics may result in subtherapeutic levels of circulating lithium.
- May prolong paralysis with tubocurarine due to hypokalemia.
✔️ Contraindications
- Severe renal impairment or anuria.
- Severe hepatic impairment, Addison's disease, preexisting hypercalcemia, asthma, hypersensitivity, severe allergy.
- Pregnancy and lactation.
✔️ Pregnancy & Lactation
Chlorthalidone should not be used as first-line therapy to treat hypertension in pregnancy. It may increase the risk to the fetus and is associated with various fetal and neonatal risks.
✔️ Precautions & Warnings
- Existing fluid and electrolyte disturbances, hepatic cirrhosis, severe heart failure, hyperuricemia, and mild to moderate renal impairment.
- Monitor fluid and electrolyte balance.
- Kidney or liver disease; diabetes; gout; hyperlipidemia; and ventricular extrasystoles.
- Lactation: Drug enters breast milk; not recommended.
✔️ Storage Conditions
Store Dydroton 25mg Tablet at room temperature in a cool and dry place. Keep it out of the reach of children and pets.
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