Tablet Manufacturer/Distributor: Eskayef Bangladesh Ltd. Generic Name: Irbesartan 75 mg Tablet
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Irbes is a medicine used to treat high blood pressure and heart disease. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes. Irbes can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is controlled. Most people with high blood pressure do not feel ill, but if you stop taking this medicine, your condition could get worse. This is a widely used medicine and is considered safe for long-term use. Making some changes in your lifestyle will also help lower your blood pressure. These may include regular exercise, losing weight, smoking cessation, reducing alcohol intake, and reducing the amount of salt in your diet as advised by your doctor. This medicine is tolerated well by most patients and has few side effects. Dizziness, particularly after the first dose, is known to occur in some people. This may be associated with headache. Let your doctor know if these side effects bother you or do not go away. No weight gain has been seen with the regular use of this medicine. Before taking this medicine, let your doctor know if you have any kidney or liver problems. Pregnant or breastfeeding mothers should also consult their doctor before taking it. Your doctor may check your kidney function, blood pressure and potassium levels in your blood at regular intervals while you are taking this medicine.
Uses of Irbes
Side effects of Irbes
Common
How to use Irbes
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Irbes may be taken with or without food, but it is better to take it at a fixed time.
How Irbes works
Irbes is an angiotensin receptor blocker (ARB). It relaxes the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently.
What if you forget to take Irbes?
If you miss a dose of Irbes, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
Essential hypertension is treated. Renal illness treatment as part of an antihypertensive medication regimen in patients with hypertension and type 2 diabetes.
Irbesartan is an antagonist of the angiotensin II receptor. It binds to AT1 receptors and prevents angiotensin II's vasoconstricting and aldosterone-secreting actions.
Diabetic nephropathy, Hypertension
Administration
May be taken with or without food.
Adult Dose
Oral Hypertension Adult: 150 mg once daily, may increase to 300 mg once daily if needed. Patient w/ intravascular volume depletion: Initially, 75 mg once daily. Elderly: >75 yr Initially, 75 mg once daily. Diabetic nephropathy in Type 2 diabetes mellitus Adult: Initially, 75-150 mg once daily, may increase to 300 mg once daily if needed.
Child Dose
Hypertension <6 years: Safety and efficacy not established 6-12 years: 75 mg/day PO initially; not to exceed 150 mg/day >12 years: 150 mg/day PO initially; may be increased to 300 mg/day PO
Renal Dose
Renal impairment: Haemodialysis: Initially, 75 mg once daily. Mild-to-severe renal impairment: Dosage adjustment not necessary unless patient is hypovolemic
Contraindication
Hypersensitivity; pregnancy and lactation.
Mode of Action
Irbesartan is an angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors.
Precaution
Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy. Lactation: Potential harm to nursing infant; discontinue drug, or do not nurse
Side Effect
>10% Hyperkalemia (19%) 1-10% Dizziness (10%),Upper respiratory tract infection (URTI) (9%),Orthostatic hypotension (5%),Fatigue (4%),Diarrhea (3%),Dyspepsia (2%)
Pregnancy Category Note
Pregnancy category: 1st trimester, C; 2nd and 3rd trimesters, D
Interaction
May antagonise hypotensive effect and increase risk of nephrotoxicity w/ NSAIDs. May increase serum lithium levels and toxicity. Increased risk of hyperkalaemia w/ K-sparing diuretics (e.g. amiloride, triamterene, spironolactone), K supplements or K-containing salt substitutes. Potentially Fatal: May increase nephrotoxic, hyperkalaemic and hypotensive effect w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).
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