Losarva 50mg Tablet

Uses of Losarva 50mg Tablet

• Hypertension
• Diabetic Nephropathy
• Hypertension with left ventricular hypertrophy

How does Losarva 50mg Tablet work?

Losartan blocks the action of angiotensin II, a chemical in your body that causes blood vessels to tighten. This relaxation of blood vessels lowers blood pressure and improves blood flow.

Side Effects of Losarva 50mg Tablet

• Dizziness, diarrhea, nasal congestion, cough, upper respiratory infection.
• Fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis.

Quick Suggestions:

1. Take Losartan at the same time every day to maintain a consistent level in your body.
2. Rise slowly from sitting or lying down to avoid dizziness.
3. Regularly monitor your blood pressure and kidney function as advised by your doctor.
4. Avoid over-the-counter NSAIDs without consulting your doctor.

Indications of Losarva 50mg Tablet

1. Hypertension: Losarva is used to treat high blood pressure (hypertension). It can be used alone or in combination with other antihypertensive agents, such as thiazide diuretics.
2. Renal Protection in Type-2 Diabetic Patients with Proteinuria: Losarva is indicated to delay the progression of renal disease in hypertensive type-2 diabetics with significant proteinuria (urinary albumin to creatinine ratio >300 mg/g).

Pharmacology

Losartan Potassium is an orally active, non-peptide angiotensin II receptor blocker. It selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues such as vascular smooth muscle, adrenal gland, kidneys, and the heart. This action reduces vasoconstriction and the release of aldosterone, both of which are responsible for increasing blood pressure.

Dosage & Administration of Losarva 50mg Tablet

• Starting Dose: 50 mg once daily.
• Maintenance Dose: If 50 mg once daily is insufficient, the dose may be adjusted to 25 mg twice daily or increased as needed.
• Volume-Depleted Patients: For patients treated with high-dose diuretics, start with 25 mg once daily.
• Maximum Daily Dose: 100 mg.
• Administration: Can be taken once or twice daily with or without food.

Special Populations:

• Patients up to 75 Years: No initial dosage adjustment is required.
• Patients Over 75 Years: Start with 25 mg once daily due to limited clinical experience.

Interaction

• Reduced Active Metabolite Levels: Rifampicin and fluconazole.
• Potentiation of Antihypertensive Effects: Hydrochlorothiazide.
• Increased Serum Potassium: Potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium.
• Attenuated Antihypertensive Effect: Non-steroidal anti-inflammatory drugs (NSAIDs) like indomethacin.
• Increased Risk of Renal Impairment: Concomitant use of ACE inhibitors, ARBs, NSAIDs, and thiazide diuretics.

Contraindications

• Pregnancy: Contraindicated due to the risk of fetal harm.
• Hypersensitivity: To any component of the product.
• Diabetes Patients: Do not use Aliskiren.

Pregnancy & Lactation

• Pregnancy Category D: Significant risk to the fetus if used during the second or third trimesters.
• Lactation: Unknown if excreted in human milk. Due to potential adverse effects on the nursing infant, decide whether to discontinue nursing or the drug.

Precautions & Warnings

• Use during the second and third trimesters can cause fetal renal dysfunction and increase morbidity and mortality.
• Symptomatic hypotension may occur in volume-depleted patients.
• Significantly increased plasma concentrations in cirrhotic patients. Consider lower doses.
• Monitor renal function, particularly in patients with renal artery stenosis.

Storage Conditions:

Store in a dry place at 15-30°C, away from light and heat. Keep out of the reach of children.