Nebipro 2.5mg Tablet 10pcs

Composition

NEBIVOLOL

Uses of Nebipro 2.5mg Tablet

• Hypertension
• Prevention of Heart Attack
• Prevention of Stroke
• Prevention of migraine attacks

Side Effects of Nebipro 2.5mg Tablet

• Headache
• Dizziness
• Unusual tiredness and weakness
• Bloating
• Weight gain
• Chest pain and discomfort
• Decreased blood pressure
• Difficulty in breathing
• Allergic Skin Reaction

How does Nebipro 2.5mg Tablet work?

Nebipro 2.5 stops the message transfer to your heart by blocking the receptors (beta-adrenergic) present in the heart. This action reduces the activity of your heart. The medicine also relaxes your blood vessels. These two mechanisms together lower your blood pressure and make it easier for your heart to pump blood throughout your body.

Quick Suggestions:

• Regularly monitor blood pressure levels to prevent hypotension (low blood pressure).
• Get up slowly while rising from a lying or sitting position as Nebipro 2.5 may cause dizziness.
• Your doctor may advise you to get a regular kidney function test and potassium levels in the body while taking Nebipro 2.5.
• Maintain a gap of two hours between Nebipro 2.5 and multivitamins and minerals as they might decrease the effects of Nebipro 2.5.

Indication of Nebivolol Tablet

Nebipro 2.5 belongs to the group of medicines called 'beta-blockers' used to treat hypertension (high blood pressure). Nebipro 2.5 is also used to treat mild to moderate heart failure in patients aged 70 years and older in addition to other therapies. 

Pharmacology of Nebivolol:

Nebivolol is a β-adrenergic receptor blocker that acts selectively on both β1 and β2 adrenergic receptors. The drug has no intrinsic sympathomimetic or membrane-stabilizing activity at therapeutic concentrations. Its beta-blocking activity is primarily due to its d-nebivolol isomer and metabolites like glucuronides, which contribute to the overall effect.

Mode of Action:

1. Decreased heart rate: By inhibiting β1 receptors, Nebivolol reduces the heart's rhythm and overall workload.
2. Decreased myocardial contractility: Lowers the force of contraction, reducing oxygen demand on the heart.
3. Sympathetic outflow suppression: Nebivolol diminishes tonic sympathetic signals from the brain to peripheral blood vessels.
4. Renin suppression: Lowers renin activity in the kidneys, contributing to decreased blood pressure.
5. Vasodilation: Induces widening of blood vessels, reducing peripheral vascular resistance.

Pharmacokinetics:

• Metabolism: Nebivolol undergoes glucuronidation and hydroxylation primarily via the enzyme CYP2D6. The active d-nebivolol isomer has a half-life of approximately 12 hours in extensive metabolizers (EMs) and 19 hours in poor metabolizers (PMs).
• Absorption: After oral administration, peak plasma levels are reached within 1.5 to 4 hours. Food does not significantly affect absorption.
• Protein Binding: Nebivolol is 98% protein-bound in plasma, predominantly to albumin, irrespective of its concentration.
• Excretion: EMs eliminate nebivolol primarily through feces (44%) and urine (38%), while PMs excrete more in urine (67%) than feces (13%).

Dosage & Administration: Nebipro 2.5mg Tablet

For Hypertension (High Blood Pressure):

• Adults: Initially, 5 mg once daily. If needed, the dose can be increased at 2-week intervals.
  • Maximum dose: 40 mg once daily.
• Elderly (65 years and older): Initially, 2.5 mg once daily, which may be increased to 5 mg once daily if required.

For Heart Failure:

• Adults: Initially, 1.25 mg once daily. If tolerated, the dose may be doubled every 1-2 weeks.
  • Maximum dose: 10 mg once daily.

For Hepatic Impairment:

• Start with 2.5 mg once daily, and increase cautiously based on tolerance.

For Renal Impairment:

• CrCl <30 mL/min: Start with 2.5 mg once daily, and increase to 5 mg once daily if needed.

Dosage should always be adjusted by a healthcare provider based on individual needs and response to treatment.

Swallow Nebipro 2.5mg Tablet with a glass of water as a whole. Do not chew, break, or crush it. You can take Nebipro 2.5mg Tablet with or without food. Take Nebipro 2.5mg Tablet at the same time daily for the best results. Based on your medical condition, your doctor will advise for how long you need to take Nebipro 2.5mg Tablet.

Drug Interactions:

Drug-Drug Interactions: Nebivolol may interact with:

• Painkillers: Aspirin, ibuprofen.
• Diuretics: Chlorthalidone, furosemide, hydrochlorothiazide.
• Antihypertensives: Amlodipine, valsartan.
• PDE5 inhibitors: Tadalafil, sildenafil.
• Anxiolytics: Alprazolam, diazepam.
• Heart medications: Digoxin, epinephrine.

Drug-Food Interactions:

• Diet: Maintain a low-salt and low-fat diet.
• Avoid alcohol as it may lower blood pressure excessively.
• Avoid high-cholesterol foods.

Drug-Disease Interactions: Inform your doctor if you have:

• Diabetes or hyperthyroidism.
• Liver or kidney impairment.
• High cholesterol or psoriasis.
• Asthma or heart problems like low blood pressure, fast heart rate, ischemic heart disease, or heart failure.

Contraindications

Avoid taking Nebivolol if you are allergic to any of its ingredients.

Pregnancy & Lactation

Nebivolol is not recommended for use during pregnancy as it can potentially harm your unborn child. Inform your doctor if you are pregnant, or planning pregnancy. Discuss the potential benefits and risks before deciding to take this medicine.

According to some human research, Nebivolol can pass into breast milk. Hence this medicine is not recommended to nursing mothers unless the benefits outweigh the risks. If you are prescribed this medicine you may need to avoid breastfeeding. Discuss the risks and benefits with your doctor before taking this medicine.

Inform your doctor if you have any of the following:

• Heart, kidney, or liver problems.
• Low blood pressure or slow heartbeat.
• Circulation issues in arms and legs.
• Recent heart failure or rhythm problems.
• Breathing issues like asthma.
• Metabolic disorders.

Do not stop or skip doses without consulting your doctor.

Conditions to watch while taking Nebivolol:

• Abnormally slow heartbeat.
• Prinzmetal’s variant angina (chest pain from heart spasms).
• First-degree heart block (heart rhythm disorder).
• Diabetes or overactive thyroid.
• Prolonged breathing problems.

Storage:

Store in a cool and dry place away from sunlight