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Nevalto 5/80mg Tablet 1 Strip
Nebivolol/Valsartan (5/80)
- Combination of a beta-adrenergic blocker (Nebivolol) and an angiotensin II receptor blocker (Valsartan), is indicated for the treatment of hypertension.
- Lowering blood pressure helps reduce the risk of fatal and nonfatal cardiovascular events such as strokes and myocardial infarctions.
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✅ Description:
- Nebivolol: A selective beta-blocker that prevents an increased heart rate, controls heart pumping strength, and helps widen blood vessels, lowering blood pressure.
- Valsartan: Blocks the action of the angiotensin II receptor (AT1 subtype), dilates blood vessels, and reduces blood pressure without affecting the pulse rate.
✔️ Side Effects:
- Hypotension
- Hyperkalemia
✔️ Dosage & Administration:
- Initial Dose: 5 mg Nebivolol / 80 mg Valsartan once daily.
- For patients already on 5 mg Nebivolol and 80 mg Valsartan, 5/80 can be substituted.
- Maximum effects are typically reached within 2 to 4 weeks.
- Increasing the dose of 5/80 does not result in significant further blood pressure reduction.
- Pediatric Use: Safety and effectiveness have not been established.
- Geriatric Use: No significant difference in safety or effectiveness compared to younger patients.
- Renal Impairment: Not recommended as initial therapy in severe renal impairment.
- Hepatic Impairment: No studies available for Nebivolol/Valsartan in patients with hepatic insufficiency.
✔️ Drug Interactions:
- CYP2D6 Inhibitors: May increase Nebivolol levels.
- Reserpine / Clonidine: May cause excessive reduction of sympathetic activity.
- Digitalis Glycosides: Increases the risk of bradycardia.
- Verapamil / Diltiazem-type Calcium Channel Blockers: May cause excessive reduction in heart rate and blood pressure.
- Potassium-sparing Diuretics or Supplements: May increase serum potassium levels.
- NSAIDs: Increased risk of renal impairment and reduced antihypertensive effect.
- Dual Inhibition of Renin-Angiotensin System: Increased risk of renal impairment, hypotension, and hyperkalemia.
✔️ Contraindications:
- Severe bradycardia
- Heart block greater than first-degree
- Cardiogenic shock
- Decompensated cardiac failure
- Sick sinus syndrome (unless a pacemaker is in place)
- Severe hepatic impairment (Child-Pugh >B)
- Hypersensitivity to any component of this product
- Do not co-administer with aliskiren in patients with diabetes.
✔️ Nebivolol Overdose:
- Bradycardia: Treat with IV atropine.
- Hypotension: Treat with IV fluids and vasopressors.
- Heart Block: Monitor and treat with isoproterenol infusion, or consider pacemaker.
- Congestive Heart Failure: Use digitalis and diuretics, consider inotropic agents.
- Bronchospasm: Administer bronchodilators.
- Hypoglycemia: Administer IV glucose.
- Supportive measures should be continued until stability.
Valsartan Overdose:
- Likely effects include hypotension and tachycardia.
- Valsartan is not removed by hemodialysis.
✔️ Pregnancy & Lactation:
- Pregnancy: Contraindicated as it can cause fetal harm.
- Lactation: Not recommended for breastfeeding.
✔️ Precautions & Warnings:
- Abrupt Discontinuation: Can exacerbate coronary artery disease; do not suddenly stop therapy.
- Diabetes: Beta-blockers like Nebivolol may mask hypoglycemia symptoms, so glucose monitoring is advised.
- Renal & Potassium Monitoring: Regular monitoring is recommended for susceptible patients.
✔️ Storage:
Store below 30°C, in a dry place, protected from light, and out of reach of children.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
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everything about particular health conditions,
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