Nifecap 10mg Soft Capsule 10pcs

Uses of Nifecap 10mg Soft Capsule

• Hypertension (high blood pressure)
• Angina (heart-related chest pain)

What if you forget to take Nifecap 10mg Soft Capsule

If you miss a dose of Nifecap, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

How does Nifecap 10mg Soft Capsule work?

Nifedipine, the active ingredient in Nifecap, is a calcium channel blocker that inhibits the influx of calcium ions into muscle cells. This leads to the dilation of arterial vessels, including major coronary and systemic arteries, reducing blood pressure and causing a reflex increase in heart rate and cardiac output.

Side Effects of Nifecap 10mg Soft Capsule

Common side effects include headache, flushing, lethargy, gravitational edema, rash, nausea, increased frequency of urination, eye pain, gum hyperplasia, depression, tremor, photosensitivity, and rare cases of jaundice. These reactions often resolve upon discontinuation of therapy. Some patients with angina pectoris may experience ischaemic pain when starting the medication.

Quick Suggestions:

• Take Nifecap 10mg Soft Capsule at the same time every day to help you remember to take it.
• A sudden drop in your blood pressure may occur, especially when you first start taking Nifecap 10mg Soft Capsule. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
• It can cause ankle or foot swelling. To reduce the swelling, raise your legs while you are sitting down. Talk to your doctor if it does not go away.
• It may cause dizziness. Do not drive or perform any activity that requires mental focus until you know how Nifecap 10mg Soft Capsule affects you.
• Inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding.

Indication of Nifecap 10mg Soft Capsule

Nifecap is indicated for managing all types of essential and renal hypertension. It is also used to manage hypertension during pregnancy and coronary bypass surgery. Additionally, Nifecap is used for the prevention and treatment of unstable and variant angina, myocardial infarction, silent myocardial ischemia, Raynaud's phenomenon, and heart failure.

Pharmacology

Nifedipine, a calcium channel blocker, inhibits the transmembrane influx of calcium ions into muscle cells. It selectively dilates arterial vessels, including major coronary and systemic arteries, leading to a reduction in blood pressure. This decrease in blood pressure triggers a sympathetic reflex response, causing tachycardia and increased cardiac output. Pulmonary arterial pressure is also reduced. At higher doses, Nifedipine has direct negative inotropic effects on cardiac muscles, which are less pronounced than its vasodilatory effects.

Dosage & Administration of Nifecap 10mg Soft Capsule

• Angina: Initially, 10 mg three times daily with food, increasing to 20 mg three times daily if necessary. For elderly patients, start with 5 mg three times daily.
• Raynaud's Phenomenon: 10 mg three times daily, with a maximum of 60 mg daily. In urgent cases, the tablet can be dissolved under the tongue for rapid effect.

For patients not previously prescribed Nifedipine, start with one tablet once daily. For hypertension and angina prophylaxis, the recommended dose is 20 mg twice daily with food. The dosage may be adjusted from 10 mg twice daily to 40 mg twice daily.

• Patients with liver dysfunction should start with 10 mg twice daily and be carefully monitored.
• No dosage adjustment is necessary for patients with renal impairment.

Interaction

• ACE Inhibitors: Enhanced hypotensive effect.
• Anti-arrhythmics: Reduced plasma concentration of quinidine.
• Antibacterials: Rifampicin may increase the metabolism of Nifecap.
• Antiepileptics: Increased plasma concentration of phenytoin.
• Antipsychotics: Enhanced hypotensive effect.
• β-blockers: Occasionally severe hypotension and heart failure may occur.
• Cyclosporin: Increased plasma concentration of Nifecap.
• Muscle Relaxants: Increased effect of muscle relaxants such as tubocurarine.
• Ulcer Healing Drugs: Increased metabolism of Nifecap.

Contraindications

Nifecap is contraindicated in patients with cardiogenic shock, advanced aortic stenosis, nursing mothers, gastrointestinal obstruction, inflammatory bowel disease, and hypotension.

Pregnancy & Lactation

There are no adequate and well-controlled studies in pregnant women. Nifecap should be used during pregnancy only if the potential benefits justify the potential risks to the fetus.

Precautions & Warnings

• Tablets should be swallowed whole and not bitten, chewed, or broken.
• Use with caution in patients with poor cardiac reserve.
• Discontinue use if ischaemic pain occurs or worsens shortly after starting treatment.
• Diabetic patients may require adjustments in their diabetes management.
• Use caution in patients with renal disease, as absorption of the drug may be altered.

Storage:

Store in the original pack, protect from strong light, and keep in a cool place.