Tablet, Generic Name: Prazosin Hydrochloride 5 mg, Manufacturer: Unimed Unihealth MFG. Ltd.
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Hypertension (primary and secondary hypertension). Cold sensitivity, Ray veteran, congestive heart failure, benign prostatic hyperplasia (for patients waiting for symptomatic treatment of urinary tract obstruction due to BPH and prostate surgery).
Prazosin causes a decrease in total peripheral vascular resistance by selective inhibition of postsynaptic alpha1-adrenergic receptors in vascular smooth muscle. In hypertensive patients, blood pressure is lowered when lying down and standing; This effect is more pronounced on diastolic blood pressure. The return of blood pressure did not occur after abruptly stopping treatment with Prazosin.
The therapeutic efficacy of Prazosin in patients with congestive heart failure is believed to decrease left ventricular filling pressure, decrease cardiac impedance, and increase cardiac output. The use of Prazosin in congestive heart failure does not induce reflex tachycardia and hypotension is minimal in hypertensive patients. Prazosin reduces the severity of signs, symptoms, frequency, and duration of attacks in patients with Raynaud's disease. At low doses, alpha1-receptor antagonism on the smooth muscle of the prostate and urethra has been shown to improve diabetes in men and improve symptoms of benign prostatic hyperplasia. Clinical studies have shown that treatment with Prazosin is not associated with undesirable changes in the serum lipid profile.
Hypertension:
Patients receiving other antihypertensive therapy but with inadequate control:
Congestive heart failure:
Raynaud's disease:
Benign prostatic hyperplasia:
Use with phosphodiesterase 5 inhibitors (PDE5 inhibitors): Simultaneous use of PDE5 inhibitors (eg, sildenafil, tadalafil, vardenafil) and prazosin may cause symptoms in some patients. Sexual hypotension Adding prazosin to treatment with beta-adrenergic antagonists or calcium antagonists can significantly lower blood pressure.
Prazosin is contraindicated in patients known to be sensitive to prazosin and other quinazolines or any excipient.
The most common side effects of prazosin are allergic reactions, depression, nervousness, insomnia, hallucinations, dizziness, drowsiness, headache, syncope, fainting, paralysis, exacerbation of existing narcolepsy, blurred vision, eye pain, reddened sclera, dizziness, dizziness, is winter. NS.
Pregnancy category C. It should be used only when, in the opinion of the physician, potential benefit outweighs potential risk. Prazosin has been shown to be excreted in small amounts in human milk. Caution should be exercised when Prazosin is administered to nursing mothers.
Patients with benign prostatic hyperplasia: Prazosin is not recommended for patients with a history of urinary syncope. Generally, it should not be administered to patients who have already received another alpha1 antagonist.
Patients with congestive heart failure: Prazosin is not recommended to treat congestive heart failure caused by mechanical obstruction such as aortic valve stenosis, mitral valve stenosis, pulmonary embolism, and restrictive pericardial disease.
In hypertensive patients: It has been reported that orthostatic hypotension manifests as dizziness and weakness, or rarely loss of consciousness, especially at the beginning of treatment.
Alpha adrenoceptor blocking drugs
Keep away from light and moisture, store below 30° C. Keep away from reach out of the children.
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