Prelizer-AM 2.5/5 Tablet 14pcs

✔️ Composition of Prelizer-AM Tablet

Bisoprolol Fumarate + Amlodipine Besilate-2.5 mg+5 mg

✔️ Uses: Prelizer-AM Tablet

• Hypertension (high blood pressure)

✔️ How does Prelizer-AM Tablet work?

Amlodipine works by relaxing your blood vessels to reduce the pressure on them, thereby controlling your blood pressure. Bisoprolol reduces the contraction of your heart muscles and causes a decrease in heart rate. This makes your heart more efficient at pumping blood throughout the body, thus controlling your blood pressure. 

✔️ Side Effects: Prelizer-AM Tablet

• Common: Dizziness, headache, drowsiness, palpitations, flushing, cold/numb extremities, nausea, diarrhea, constipation, abdominal pain, edema, fatigue.
• Uncommon: Insomnia, mood changes, depression, sleep disturbances, sensory changes, vision problems, heart issues, dyspnea, bronchospasm, digestive issues, skin reactions, muscle pain, urinary problems, sexual dysfunction, chest pain.
• Rare: Allergic reactions, nightmares, hallucinations, liver enzyme changes.

✔️ Some word of Advice:

• You have been prescribed Amlodipine + Bisoprolol for the treatment of high blood pressure.
• Lowering blood pressure reduces the chance of future heart attacks & strokes.
• It may cause dizziness. Get up slowly when rising from a sitting or lying position.
• Do not stop taking the medication suddenly without talking to your doctor as it can cause a sudden increase in your blood pressure.
• Do not discontinue taking AMLODIPINE+BISOPROLOL FUMARATE abruptly or without the advice of the physician.
• Let your doctor know if you are pregnant or planning for pregnancy.

✔️ Indications: Prelizer-AM Tablet

Hypertension or high blood pressure is a chronic condition in which the force exerted by the blood against the artery wall is high. As a result, it leads to heart disease, irregular heartbeat, and other complications. Prelizer-AM Tablet is used to treat high blood pressure. Prelizer-AM Tablet lowers blood pressure and helps reduce the risk of having a stroke, heart attack, other heart problems, or kidney problems in the future. 

✔️ Pharmacology

This combination includes Amlodipine, a calcium channel blocker, and Bisoprolol Fumarate, a beta1-selective adrenergic blocker. Amlodipine works by inhibiting calcium ion influx into vascular and cardiac muscle cells, primarily affecting vascular smooth muscle and leading to reduced peripheral resistance and blood pressure. Bisoprolol selectively blocks beta1-adrenergic receptors, minimizing effects on airway resistance and metabolic regulation, thus primarily acting on the cardiovascular system without significant bronchial or metabolic effects.

✔️ Dosage & Administration of Prelizer-AM Tablet

Take one tablet daily in patients whose blood pressure is adequately controlled with separate monocomponent products of the same doses as the fixed-dose combination. Use as prescribed by a registered physician.

• Elderly: Usual doses apply, but dose increases should be done cautiously.
• Children: Not recommended for use in patients under 18 years.
• Liver disease: Administer with caution, especially in severe impairment.
• Kidney disease: Caution with severe impairment; bisoprolol dose should not exceed 10 mg/day.

✔️ Interaction

• Not recommended: Calcium channel blockers like verapamil or diltiazem, centrally-acting antihypertensive drugs.
• Use with caution: CYP3A4 inhibitors/inducers, simvastatin, tacrolimus, cyclosporine, antiarrhythmic drugs, parasympathomimetic drugs, topical beta-blockers, insulin, oral antidiabetics, NSAIDs, anesthetics, digitalis glycosides, sympathomimetics, other antihypertensives.
• Combinations to consider: Mefloquine, rifampicin, ergotamine derivatives, and MAO inhibitors (except MAO-B inhibitors).

✔️ Contraindications

Not to be used in acute heart failure, severe aortic stenosis, cardiogenic shock, advanced AV block, sick sinus syndrome, bradycardia, severe asthma, severe peripheral artery disease, untreated pheochromocytoma, or metabolic acidosis. Also contraindicated in patients allergic to bisoprolol, amlodipine, or related compounds.

✔️ Pregnancy & Lactation

Not recommended during pregnancy or lactation.

✔️ Precautions & Warnings

• Use with caution in heart failure patients, as abrupt discontinuation may worsen the condition, particularly in ischemic heart disease.
• Caution is required for patients with liver or kidney issues, diabetes, bronchospasm, psoriasis, and peripheral artery disease.
• Monitor for symptoms of hypothyroidism or hypoglycemia, and manage beta-blocker withdrawal gradually.
• Avoid in cases of psoriasis unless the benefit outweighs the risk.
• Caution in surgeries requiring general anesthesia due to beta-blockade effects.
• Symptoms include bradycardia, hypotension, bronchospasm, acute heart failure, and hypoglycemia. Amlodipine overdose can lead to extreme vasodilation, reflex tachycardia, and potentially fatal shock. Treatment is supportive and symptomatic.

✔️ Storage Conditions:

Store in a dry place, below 30°C, and protect from light. Keep out of children's reach.