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Ajuben 6 Tablet | 1 Strip
Ajuben is prescribed for:
- Chorea linked to Huntington's disease
- Tardive dyskinesia in adults
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Regular Delivery - 12-24 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Ajuben (deutetrabenazine) acts as a reversible inhibitor of vesicular monoamine transporter 2 (VMAT2).
It reduces the uptake and storage of neurotransmitters like dopamine, serotonin, norepinephrine, and histamine in nerve terminals.
This depletion of monoamines helps control abnormal involuntary movements (chorea and dyskinesia).
✔️ Use in Special Populations
Pediatrics: Not established in patients under 18
Hepatic/Renal Impairment: No specific studies available; use caution
Poor CYP2D6 Metabolizers: Limit dose to 36 mg/day (18 mg twice daily)
✔️ Side Effects
- Sleepiness
- Dry mouth
- Diarrhea
- Fatigue
✔️ ✅ If NOT previously on tetrabenazine:
| Condition | Initial Dose | Maintenance Range | Max Dose |
|---|---|---|---|
| Chorea (Huntington’s) | 6 mg/day | 6–48 mg/day | 48 mg/day |
| Tardive Dyskinesia | 12 mg/day | 12–48 mg/day | 48 mg/day |
Titrate by 6 mg/day weekly
Divide doses ≥12 mg (e.g., 24 mg = 12 mg twice daily)
Take with food
✔️ 🔄 Switching from Tetrabenazine:
| Tetrabenazine Dose | Initial Ajuben Dose |
|---|---|
| 12.5 mg | 6 mg once daily |
| 25 mg | 6 mg once daily |
| 37.5 mg | 9 mg once daily |
| 50 mg | 12 mg once daily |
| 62.5 mg | 15 mg once daily |
| 75 mg | 18 mg once daily |
| 87.5 mg | 21 mg once daily |
| 100 mg | 24 mg once daily |
Adjust Ajuben weekly as needed for clinical response.
✔️ Storage ConditionOverdose Effects: Symptoms may include:
- Dystonia, oculogyric crisis
- Confusion, hallucinations
- Nausea, vomiting, tremor
- Hypotension, sedation
✔️ Drug Interactions
Avoid strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): Maximum dose = 36 mg/day
Avoid alcohol and sedatives: May cause additive drowsiness
✔️ Do not use Ajuben in patients with:
- Active suicidal thoughts or untreated depression
- Hepatic impairment
- Concurrent use of MAOIs, reserpine, or tetrabenazine
✔️ Monitor for:
- Neuroleptic Malignant Syndrome (NMS) – Stop Ajuben if suspected
- Parkinsonism, Akathisia, Agitation, or Restlessness – Dose adjustment or discontinuation may be required
- Somnolence/Sedation – Avoid activities requiring alertness if affected
✔️ Pregnancy & Lactation
Pregnancy: Not enough human data – use only if clearly needed
Breastfeeding: Unknown if secreted in milk – caution advised
✔️ Storage
- Store below 30°C
- Keep away from light and moisture
- Keep out of children’s reach
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
