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Azo is prescribed for bacterial infections caused by susceptible organisms, including:
- Respiratory Infections: Bronchitis, pneumonia, sinusitis, pharyngitis, tonsillitis.
- Ear, Skin, and Soft Tissue Infections
- Sexually Transmitted Infections: Non-gonococcal urethritis and cervicitis caused by Chlamydia trachomatis.
Use medication only as directed by a registered physician.
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✅ Description:
Azithromycin is acid-stable and effectively absorbed when taken orally, especially on an empty stomach. It reaches peak concentration in 2.1 to 3.2 hours. The drug accumulates in phagocytes and is released at infection sites. It has a long half-life, allowing prolonged action even after a single dose. Excretion occurs mainly through bile, with a small percentage eliminated via urine.
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✔️ Mechanism of Action
Azithromycin binds to the 50S ribosomal subunit of bacteria, disrupting protein synthesis. It is effective against:
- Gram-positive bacteria: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes.
- Gram-negative bacteria: Haemophilus influenzae, Neisseria gonorrhoeae.
- Other pathogens: Chlamydia pneumoniae, Mycoplasma pneumoniae, Legionella pneumophila.
✔️ Oral Dosage
- Adults:
- 500 mg daily for 3 days, or
- 500 mg on day 1, then 250 mg daily for 4 more days.
- For Chlamydia: 1 g as a single dose, or 500 mg on day 1, followed by 250 mg daily for 2 days.
- Children (over 6 months):
- 10 mg/kg once daily for 3 days.
- Adjusted dosages based on body weight:
- 15-25 kg: 200 mg/day
- 26-35 kg: 300 mg/day
- 36-45 kg: 400 mg/day
- For Typhoid Fever: 500 mg daily for 7-10 days.
✔️ Drug Interactions
- Antacids: Take azithromycin at least 1 hour before or 2 hours after antacids.
- Carbamazepine, Methylprednisolone: No significant interaction.
- Cyclosporin, Digoxin: May require dosage adjustments.
- Ergot Derivatives: Avoid co-administration due to risk of ergotism.
- Warfarin: No significant effect, but monitor prothrombin time.
- Theophylline: No known interaction, but monitoring is advised.
✔️ Contraindications
- Do not use in patients allergic to azithromycin or macrolide antibiotics.
- Avoid in patients with liver disease.
✔️ Side Effects
- Common: Nausea, abdominal pain, vomiting, gas, diarrhea.
- Rare: Allergic reactions, liver enzyme elevations, hearing loss at high doses.
✔️ Pregnancy & Lactation
- Pregnancy Category B: No proven harm in animal studies, but human data is limited. Use only if necessary.
- Lactation: Unknown if excreted in breast milk; use with caution.
✔️ Warnings & Precautions
- Severe Allergic Reactions: Rare but possible; prolonged monitoring may be required.
- Renal Impairment: Use with caution in severe kidney disease.
- Hepatic Impairment: Avoid use in liver disease.
✔️ Storage:
Store in a dry place, away from heat and light. Keep out of children’s reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
