Cefixime acts by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is stable against β-lactamase enzymes, allowing it to treat infections caused by bacteria resistant to penicillins and some earlier-generation cephalosporins. The oral absorption rate is about 40–50%, and it remains effective whether taken with or without food.
Overdose Effects
There is no specific antidote. Gastric lavage and symptomatic treatment may be used. Cefadyl is not effectively removed by hemodialysis or peritoneal dialysis. High single doses (up to 2 g) in volunteers produced no significant adverse effects beyond the usual profile.
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Cefadyl is an orally active third-generation cephalosporin antibiotic with broad-spectrum bactericidal activity against both Gram-positive and Gram-negative organisms. It is stable in the presence of beta-lactamase enzymes, making it effective against resistant bacterial strains. Cefadyl is indicated for the treatment of acute infections caused by susceptible bacteria, including:
It is effective against pathogens like Streptococcus pneumoniae, S. pyogenes, E. coli, Proteus mirabilis, Klebsiella spp., Haemophilus influenzae (β-lactamase positive and negative), Moraxella catarrhalis, and Enterobacter spp.
Food has minimal effect on Cefixime absorption. The usual treatment duration is 7 days, which may extend up to 14 days if necessary.
Adults & children over 10 years: 200–400 mg daily (single dose or divided doses) based on infection severity.
Elderly: Same as adults; dose adjustment may be required in severe renal impairment.
Children (6 months–10 years): 8 mg/kg/day as a single or divided dose.
6 months–1 year: 3.75 ml daily
1–4 years: 5 ml daily
5–10 years: 10 ml daily
For typhoid: 5 mg/kg twice daily for 10–14 days
Children over 50 kg or above 10 years: Adult dosage.
Children under 6 months: Safety not established.
Renal impairment:
Creatinine clearance ≥20 ml/min: Normal dose.
<20 ml/min: Do not exceed 200 mg once daily.
Dialysis patients: Same as those with severe renal impairment.
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As with other cephalosporins, prolonged prothrombin times may occur in some patients. Use caution in individuals receiving anticoagulant therapy.
Hypersensitivity to Cefixime or any cephalosporin antibiotic.
There are no adequate studies in pregnant women. Cefadyl should be used during pregnancy only if clearly necessary. It is unknown whether Cefixime is excreted in human milk, so caution is advised during lactation.
Store below 30°C, protected from light and moisture. Keep out of children’s reach.
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