Generic Name: Sulphamethoxazol 800mg + Trimethoprim 160mg
Manufacturer/Distributor: Square Pharmaceuticals Ltd.
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Indications
A combination drug called Cotrim DS is used to treat a variety of bacterial infections, including those of the urinary tract, ear, abdomen, bronchitis, and pneumonia. To treat the infection, it stops the growth of microorganisms.
Pharmacology
The antibiotic cotrimoxazole has a broad spectrum of bactericidal activity against a variety of gram-positive and gram-negative microbes as well as a few protozoa. Co-trimoxazole, which combines Trimethoprim and Sulphamethoxazole in a 1:5 ratio, exerts its bactericidal activity by sequentially disrupting two bacterial protein frameworks involved in the microorganism's biosynthesis of folinic acid corrosive.
Administration & Dosage
Over 12 years Cotrimoxazole double-strength tablet
Tablet of cotrimoxazole: over 12 years
Interaction
It is recommended to wait at least two weeks after stopping an MAOI before starting antidepressants like SSRIs and related antidepressants. Contrarily, an MAOI shouldn't be started until at least a week has passed since the last dose of an SSRI or comparable antidepressant (2 weeks in the case of paroxetine and sertraline, at least 5 weeks in the case of fluoxetine).
Contraindications
Touchiness to sulphonamides or trimethoprim. individuals with a history of megaloblastic weakness brought on by a folate deficiency. Patients display blood dyscrasia, severe renal failure, and glucose 6-phosphate dehydrogenase insufficiency in addition to stamped liver parenchymal damage.
Side Effect
Rarely described side effects of the sulphamethoxazole-trimethoprim combination include crystalluria, unfavorably susceptible responses, hemolysis, thrombocytopenia, neutropenia, agranulocytosis, etc. Other side effects, such as unease, headaches, nausea, and spitting, are of a less real nature. These are typically temporary and don't call for stopping treatment.
Pregnancy & Lactation
The risks and benefits of treating a pregnant woman with Escitalopram during the third trimester should be carefully considered by the physician. It's passed through human breast milk. The risk of citalopram exposure for the infant and the benefits of Escitalopram treatment should be considered when deciding whether to continue or stop nursing or Escitalopram therapy.
Precautions & Warnings
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.
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